Yazar "Şahin, Ertan" seçeneğine göre listele
Listeleniyor 1 - 9 / 9
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe 4-Methyl morpholinium bis-(thio)barbiturates: Synthesis, structure, anticancer evaluation, and CoMFA study(Chinese Chemical Society Taiwan, 2020) Noroozi Pesyan, Nader; Rashidnejad, Hamid; Safari, Elnaz; Tunç, Tuncay; Alilou, Mostafa; Safavi-Sohi, Reihaneh; Şahin, Ertan; Esmaeili, Mohammad AliThe reaction of symmetrical (thio)barbituric acids with aldehydes in the presence of 4-methyl morpholine yielded a new form of 4-methyl morpholinium bis-(thio)barbiturate containing charge-separated intermolecular and eight-membered intramolecular H-bonds. X-ray Crystallography, FT-IR, and 1H and 13C-NMR spectroscopy techniques were used for structure characterizations. Some of these compounds showed potent anticancer activities. Cytotoxicity of the synthetic compounds against HeLa and MCF-7 cell lines were performed by MTT assay. In addition, a comparative molecular field analysis was carried out, and the effects of substituents on the biological activities of these compounds were explained.Öğe 4-Methylmorpholinium bis-(thio)barbiturates: Synthesis, structure, anticancer evaluation, andCoMFAstudy(Wiley-VCH, 2020) Pesyan, Nader Noroozi; Rashidnejad, Hamid; Esmaeili, Mohammad Ali; Safari, Elnaz; Tunç, Tuncay; Alilou, Mostafa; Safavi-Sohi, Reihaneh; Şahin, ErtanThe reaction of symmetrical (thio)barbituric acids with aldehydes in the presence of 4-methyl morpholine yielded a new form of 4-methyl morpholinium bis-(thio)barbiturate containing charge-separated intermolecular and eight-membered intramolecularH-bonds. X-ray Crystallography, FT-IR, and(1)H and(13)C-NMR spectroscopy techniques were used for structure characterizations. Some of these compounds showed potent anticancer activities. Cytotoxicity of the synthetic compounds against HeLa and MCF-7 cell lines were performed by MTT assay. In addition, a comparative molecular field analysis was carried out, and the effects of substituents on the biological activities of these compounds were explained.Öğe An anomalous addition of chlorosulfonyl isocyanate to a carbonyl group: the synthesis of ((3aS, 7aR, E)-2-ethyl-3-oxo-2,3,3a, 4,7,7a-hexahydro-1H-isoindol-1-ylidene)sulfamoyl chloride(Beilstein-Institut, 2019) Köse, Aytekin; Ünal, Aslı; Şahin, Ertan; Bozkaya, UĞur; Kara, YunusIn this study, we developed a new addition reaction of chlorosulfonyl isocyanate (CSI), starting from 2-ethyl-3a, 4,7,7a-tetrahydro-1H- isoindole-1,3(2H)-dione. The addition reaction of CSI with 2-ethyl-3a, 4,7,7a-tetrahydro-1H-isoindole-1,3(2H)-dione resulted in the formation of ylidenesulfamoyl chloride, whose exact configuration was determined by X-ray crystal analysis. We explain the mechanism of product formation supported by theoretical calculations.Öğe Diels-Alder reactions: The effects of catalyst on the addition reaction(Elsevier, 2015) Yılmaz, Özgür; Şimşek Kuş, Nermin; Tunç, Tuncay; Şahin, ErtanThe reaction between 2,3-dimethyl-1,3-butadiene and dimethyl 7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate is efficiently achieved with small amounts of catalyst, i.e. phenol, AcOH, nafion, and beta-cyclodextrin. Exo-diastereoselective cycloaddition reactions were observed both without catalyst and different catalysts for 48 days. As a result, different products (tricyclicmolecule 5, retro-Diels-Alder product 6, and oxidation product 7) were obtained with different catalysts. In addition, we synthesized Diels-Alders product 8 and tricyclocyclitol 10 via Diels-Alder reaction. The structures of these products were characterized by H-1 NMR, C-13 NMR, MS and IR spectroscopy. (C) 2015 Elsevier B.V. All rights reserved.Öğe Regioselective one-pot synthesis of new unsymmetric spiro dihydrofurans in the reaction of mixed two different cyclic ?-dicarbonyl compounds with BrCN and aldehydes in the presence of Et3N(WILEY-V C H VERLAG GMBH, 2015) Pesyan, Nader Noroozi; Shokr, Alireza; Gharib, Ali; Tunç, Tuncay; Şahin, ErtanCrossed one-pot reaction of mixed cyclic beta-dicarbonyl with various aldehydes in the presence of cyanogen bromide and triethylamine leads to the selective and efficient formation of crossed new unsymmetrical spiro dihydrofurans at room temperature. The products were obtained in good to excellent yields. Structure elucidation was carried out by H-1 NMR, C-13 NMR, FT-IR spectroscopy, Mass analyses and X-ray crystallography technique. A proposed mechanism was discussed for the formation of products.Öğe Synthesis and biological evaluation of new chloro/acetoxy substituted isoindole analogues as new tyrosine kinase inhibitors(Academic Press, 2020) Köse, Aytekin; Kaya, Meltem; Akdemir, Atilla; Şahin, Ertan; Kara, Yunus; Şanlı Mohamed, Gülşah; Kishalı, Nurhan HorasanWe have developed a versatile synthetic approach for the synthesis of new isoindole derivatives via the cleavage of ethers from tricyclic imide skeleton compounds. An exo-cycloadduct prepared from the Diels–Alder reaction of furan and maleic anhydride furnished imide derivatives. The epoxide ring was opened with Ac2O or Ac2O/AcCl in the presence of a catalytic amount of H2SO4 in order to yield new isoindole derivatives 8a-d and 9a-d. The anticancer activity of these compounds was evaluated against the HeLa cell lines. The synthesized compounds showed inhibitory effects on the viability of HeLa cells and the degree of cytotoxicity was increased with the level of bigger branched isoindole derivatives. To better understand the acting mechanism of these molecules, western blot analysis was performed with using mTOR and its downstream substrates. In addition, human mTOR and ribozomal S6 kinase ?1 (RS6K?1) have been investigated with molecular modelling studies as possible targets for compound series 8 and 9.Öğe Synthesis of Bis-spiro Cyclopropanes Based on Meldrum's Acid by Milling(Wiley-Blackwell, 2015) Kashani, Elmira; Pesyan, Nader Noroozi; Tunç, Tuncay; Şahin, ErtanReaction of 2,2-dimethyl-1,3-dioxane-4,6-dione (Meldrum's acid) with various solid aldehydes in the presence of cyanogen bromide and solid sodium ethoxide (EtONa) leads to the selective and efficient formation of bis-spiro cyclopropanes based on Meldrum's acid at the range of 0 degrees C to room temperature. The products were obtained in good to excellent yields. Structure elucidation is carried out by H-1 NMR, C-13 NMR, FT-IR spectroscopy, mass analyses and X-ray crystallography techniques. A possible mechanism for the formation of products is also discussed under solvent-free condition.Öğe Synthesis of tricyclic ring systems: [2+2] ketene addition reaction for preparation of tricyclic ketone, alcohol, and lactone derivatives(Springer International Publishing Ag, 2017) Yılmaz, Özgür; Yıldız Bekfelavi, Esen; Şimşek Kuş, Nermin; Tunç, Tuncay; Şahin, ErtanThe addition of dichloroketene to 1,4-cyclohexadiene was examined. Dichloroketene, which was easily prepared from trichloroacetyl chloride and Zn-Cu, reacted with 1,4-cyclohexadiene in the presence of POCl3 to afford novel racemic products of single addition (5) and double addition (6). The adducts 6 and 7 were reacted separately with MCPBA (meta-chloroperbenzoic acid), H2O2, LiAlH4, and cis-diol 10 was reacted with PCC (pyridinium chlorochromate) to afford lactone, alcohol, and ketone derivatives likely to exhibit biological activity. The structures of all the racemic molecules mentioned in the article were determined from H-1 NMR, C-13 NMR, MS, and IR data.Öğe Synthesis, crystal structure, and spectroscopic studies of n-(4-bromobenzylidene)-n '-(2-pyridyl) hydrazine schiff base molecule(Taylor & Francis Ltd, 2012) Tunç, Tuncay; Tezcan, Habibe; Şahin, Ertan; Dilek, NefiseA new Schiff base complex N-(4-bromobenzylidene)-N'-(2-pyridyl) hydrazine, C12H10N3Br, has been synthesized and characterized by elemental analyses, mass, H-1 NMR, ultraviolet-visible (UV-VIS), and IR spectroscopy and single-crystal X-ray determination. The p-Br-benzene and pyridine rings are almost planar and the dihedral angle between the planes is 11.1(3)degrees. The crystal structure is stabilized by intermolecular N-H center dot center dot center dot N-Py hydrogen bonding interaction. X-ray diffraction analyses show that N-(4-bromobenzylidene)-N'-(2-pyridyl) hydrazine Schiff base molecule crystallizes in the monoclinic system, P2(1)/c space group, a = 5.611(5) angstrom, b = 19.566(5) angstrom, c = 10.715(5) angstrom, beta = 98.766(5)degrees, and V = 1162.60(12) angstrom(3).
