Aksaray Üniversitesi Kurumsal Akademik Arşivi
DSpace@Aksaray, Aksaray Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Catalyst-driven strategies for organic matter and disinfection byproduct removal: Comparing adsorption, ozonation, and catalytic ozonation
(Elsevier Ltd, 2025) Alver, Alper; Baştürk, Emine; Kılıç, Ahmet; Altınışık Tagaç, Aylin
Effective removal of natural organic matter (NOM) and its disinfection byproduct (DBP) precursors is vital for ensuring drinking water safety. This study systematically compared adsorption, sole ozonation, and catalytic ozonation using TiO2, goethite, silver nanoparticles, and iron-coated pumice as catalysts. Treatment performance was evaluated based on reductions in dissolved organic carbon (DOC), UV absorbance at 220, 254, and 272 nm, and DBP formation potentials (trihalomethanes (THMs) and haloacetic acids (HAAs)). Catalytic ozonation with TiO2 exhibited superior performance, achieving ~87 % DOC removal and > 93 % reduction in UV254 and UV272 absorbance. It also led to a > 94 % decrease in THM and HAA formation potentials, resulting in estimated carcinogenic risks well below regulatory thresholds set by the WHO and EPA. These risk estimates carry inherent uncertainties, particularly for emerging DBPs, yet remain valid indicators for comparing treatment efficacy. Goethite also demonstrated high DBP precursor removal (~73 %) with relatively low operational cost, while iron-coated pumice achieved moderate effectiveness (~67 %) but suffered from reduced longevity. Adsorption and sole ozonation were notably less effective. Statistical analysis confirmed significant performance differences among the catalysts, with TiO2 emerging as the most efficient and cost-effective option. The enhanced performance of TiO2 was attributed to its strong oxidative properties and affinity for both aromatic and aliphatic NOM fractions. These findings underscore the potential of catalyst-enhanced ozonation as a powerful strategy for NOM and DBP control, providing a technically and economically viable path toward meeting increasingly stringent drinking water standards and reducing long-term public health risks. © 2025 Elsevier Ltd.
Zingerone ameliorates sodium arsenite-induced cardiotoxicity in rats by suppressing oxidative stress and inflammation via Nrf2 /GCLM\GCLC signaling pathways
(Elsevier GmbH, 2025) Kandemir, Özge; Kandemir, Fatih Mehmet; Akaras, Nurhan; Küçükler, Sefa; Gür, Cihan; İleritürk, Mustafa; Şimşek, Hasan; Gül, Murat
Arsenic toxicity is a serious threat to human health, transmitted through many factors in the environment, especially water and contaminated food. Epidemiologic studies have reported that arsenite increases mortality and morbidity by causing cardiac damage, but the mechanism of action on cardiotoxicity remains to be elucidated. Zingerone (ZNG) obtained from ginger root is a monomer with pharmacological effects such as antioxidant, anti-inflammatory, and anticancer. This study was conducted to investigate the protective potential of zingerone against sodium arsenite-induced cardiac damage in rats. Sodium arsenite (SA) (10 mg/kg) was administered to rats for 14 days to induce cardiotoxicity, while zingerone (25 and 50 mg/kg) was administered for treatment. Then, oxidative stress markers, inflammatory factors, and apoptosis-related proteins were evaluated by molecular and biochemical methods. It was also supported by histological and immunohistochemical stainings. According to the results, ZNG treatment significantly reduced SA-induced altered cardiac functions. Compared with the SA group, rats co-treated with SA and ZNG showed a significant decrease in oxidant markers and an increase in antioxidant levels. Additionally, ZNG treatment regulated the expression of NRF2, HO-1, NQO1, GCLM, and GCLC genes related to oxidative stress. Moreover, treatment with ZNG significantly inhibited arsenite-induced apoptosis (p53, Apaf-1, Bax, Bcl-2, Casp-3, Casp-6, Casp-9) while reducing the levels of inflammatory mediators including NF-κB, TNF-α, IL-1β, COX-2 and iNOS in cardiac tissue. Finally, co-administration of ZNG with SA reduced SA-induced cardiac histopathological changes in rats. The results of this study suggest that ZNG may provide an alternative for clinical inflammation control through antioxidant and anti-inflammatory activities. © 2025 Elsevier GmbH
Evaluation of computational modeling approaches for continuous flow microwave processing of multiphase food products (solid-liquid mixtures)
(Elsevier B.V., 2025) Karataş, Ozan; Şahin, Kübra Bulduk; Uyar, Rahmi; Erdoğdu, Ferruh
Evaluation of conventional thermal processing for multiphase food products (e.g., solid – liquid mixtures) is based on the temperature change of the fastest moving particle. This leads to over-processing of other particles. While a proper process design is required, experimental temperature measurement is a difficult task. Hence, computational approaches should be preferred for this purpose. Besides this challenge, conventional processes are to be replaced with novel approaches for sustainability. Microwave (MW) heating might be considered as a novel approach, but its application in such a process increases the complexities in the view of non-uniform temperature distribution. Therefore, the objective of this study was to computationally evaluate the computational modeling approaches for determining the temperature distribution during MW processing of multiphase (solid – liquid mixture) food products for process design purpose. A commercial finite element solver was used for this purpose, and a process design study for a continuous flow MW process was also introduced. Pros and cons of particle tracing and moving mesh approaches were discussed, and an improved modeling approach was presented for process design of multi-particle continuous flow MW processing. The results of this study are expected to provide detailed information from the idea to the industrial scale application due to the designed process parameters.
Determination of the functional, nutritional, and some quality properties of kefir produced with the addition of germinated chickpeas
(John Wiley and Sons Ltd, 2025) Kahve, Ayşe Nur; Bayrak, Ebru
Global population growth and rising health consciousness have increased the demand for sustainable and functional foods. This study aimed to enhance the nutritional value of chickpeas (Cicer arietinum L.) and evaluate the functional and quality characteristics of kefir enriched with germinated chickpeas. Germination conditions were optimized, and chickpea samples were analyzed for protein, moisture, ash, and total phenolic content. Principal component analysis (PCA) identified the optimal germination parameters. Kefir samples were prepared by incorporating ungerminated chickpeas, inulin, or optimally germinated chickpeas at concentrations of 0.5%, 1%, and 2%, and stored at 4°C ± 1°C for 7 days. Physicochemical, microbiological, and sensory analyses were performed on Day 1 and 7. The highest protein (14.99%) and total phenolic content (9.05 mg GAE/g) were observed in chickpeas soaked for 12 h at 30°C and germinated for 72 h. Kefir pH values ranged from 4.01 to 4.75 (p < 0.05). Increasing the concentration of germinated chickpeas significantly improved the total phenolic content (p < 0.05), and yeast growth was detected exclusively in these samples (p < 0.05). However, sensory evaluation scores declined with higher chickpea concentrations. In conclusion, kefir enriched with germinated chickpeas demonstrates enhanced nutritional and microbiological properties, indicating its potential as a functional beverage. Nevertheless, further improvements are necessary to optimize its sensory characteristics for consumer acceptance.
Association between air pollution and climate parameters exposure during the periconceptional period and hypospadias risk in Turkish offspring: A case-control study
(Elsevier B.V., 2025) Demirtaş, Mehmet Semih; Yalçın, Sıddıka Songül; Tusat, Mustafa; Özmen, İsmail; Başar, Dilek; Calapoğlu, Ahmet Salih Calapoglu, Ahmet Salih lu, Ahmet Salih; Siyve, Serdar; Demirtaş, Orhan; Altıntaş Ural, Dilan
We aimed to investigate the associations between hypospadias and contact to air pollutants and climate parameters during the pre- and post-conceptional periods. This study has been carried out as a multicentre case-control study involving 340 children with hypospadias between the ages of 0–3 years and 357 children in the same age range who applied for circumcision. A total of 7 air pollutant (PM2.5, PM10, NO, NO2, SO2, CO, O3), 5 climate parameters [air temperature, relative humidity (RH), air pressure (AP), wind speed (WS) and precipitation amounts data were obtained. In the multivariate logistic regression analysis, younger maternal age (reference: >35 years) and maternal smoking (reference: no exposure) were significantly associated with a higher likelihood of hypospadias. Conversely, folic acid supplementation intake during pregnancy (reference: no supplementation) and maternal BMI in the range of 25–30 (reference: <25) were associated with a lower likelihood of its occurrence. After adjusting for child-family characteristics, increased interquartile ranges (IQR) of CO, mean temperature, minimum temperature, RH, and AP were positively associated with hypospadias, whereas SO2 levels and diurnal temperature range (DTR) were inversely associated. Comprehensive analysis of individual and environmental factors further highlighted that younger maternal age, smoking exposure, PM10, and air pressure were positively associated with hypospadias, while a greater DTR was inversely associated. Younger maternal age, smoking exposure, and specific air pollutants, such as PM10 and CO, as well as climatic factors like AP, were positively associated with hypospadias. These findings underscore the importance of mitigating environmental exposures and promoting maternal health interventions to reduce the risk of congenital anomalies like hypospadias. Further longitudinal studies are warranted to confirm these associations and explore underlying mechanisms.
