Aksaray Üniversitesi Kurumsal Akademik Arşivi
DSpace@Aksaray, Aksaray Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Systemic ınflammatory markers (NLR/PLR) and climatic factors as predictors of severity in pediatric carbon monoxide poisoning
(Effect Publishing Agency ( EPA ), 2025) Memiş, Sebahattin; Demirtaş, Mehmet Semih; Erdal, Hüseyin; Sorkulu Memiş, Gizem; Tuşat, Mustafa; Özdemir Kaçer, Emine
Carbon monoxide (CO) poisoning remains a global health challenge, particularly in developing nations. This study evaluates the prognostic role of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and climatic parameters in pediatric CO poisoning severity. Material and Method: In this retrospective cohort study, 132 pediatric patients admitted to a tertiary emergency department were stratified by carboxyhemoglobin (COHb) levels (mild: <5%; moderate: 5–25%; severe: >25%). Associations between NLR/PLR, meteorological data (temperature, wind speed, air pressure), and clinical outcomes were analyzed. Results: Severe cases exhibited significantly elevated NLR (2.09 [IQR 1.24-3.54]; p=0.019) and PLR (106.2 [80.6-164.4]; p=0.032) compared to others, alongside higher COHb (31.45 [27.25-34.2]; p<0.001) and lactate (2.7 [1.8-3.45] mmol/L; p=0.07). Central nervous system symptoms (CNS) predominated in severe poisoning (28.6%, p=0.014). Maximum temperature was inversely correlated with severity (p=0.032). Conclusion: NLR and PLR serve as early indicators of CO poisoning severity, while higher air temperatures reduce risk. These findings support using routine hemogram indices for risk stratification and underscore the need for climate-aware public health interventions.
Systemic inflammatory indices in preterm preeclampsia versus term preeclampsia and healthy pregnancies: a retrospective case-control study
(Effect Publishing Agency ( EPA ), 2025) Aslan, İlke Özer; Erdal, Hüseyin
This study aimed to investigate whether systemic inflammatory indices derived from first-trimester complete blood counts— namely the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and pan-immune-inflammation value (PIV)—differ among women with preterm preeclampsia, term preeclampsia, and healthy pregnancies. Material and Method: In this retrospective case–control study, 197 pregnant women were evaluated and categorized into three groups: preterm preeclampsia (n=39), term preeclampsia (n=59), and healthy controls (n=99). Demographic, perinatal, and hematological data were retrieved from medical records. Inflammatory indices were calculated from complete blood count parameters obtained during the first trimester. Statistical comparisons across groups were performed using one-way ANOVA or Kruskal–Wallis test, with a significance threshold of p<0.05. Results: While neutrophil counts and hemoglobin levels were significantly higher in preeclampsia groups compared to controls (p=0.001 and p<0.001, respectively), there were no statistically significant differences among groups in terms of NLR (p=0.063), PLR (p=0.750), SII (p=0.100), SIRI (p=0.110), or PIV (p=0.091). Birth weight, birth length, and Apgar scores were significantly lower in the preterm preeclampsia group (p<0.001 for all), reflecting more severe neonatal outcomes. Conclusion: Despite differences in neutrophil count and hemoglobin concentration, systemic inflammatory indices derived from first-trimester blood counts did not significantly differentiate preterm preeclampsia from term preeclampsia or healthy pregnancies. These findings suggest limited utility of these indices as standalone diagnostic markers in early pregnancy. Future prospective studies incorporating serial measurements and multimodal predictive models are warranted.
Relationship of prognostic nutritional ındex, HALP score and ınflammatory markers with clinical outcomes in children with complicated appendicitis
(Effect Publishing Agency ( EPA ), 2025) Tuşat, Mustafa; Memiş, Sebahattin; Demirtaş, Mehmet Semih
One of the most frequent diagnoses in children presenting with acute abdominal pain is acute appendicitis. This study aims to analyze the effectiveness of the biomarkers such as the Prognostic Nutrition Index (PNI), hemoglobin-albumin-lymphocyte-platelet (HALP) score, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) in predicting complicated appendicitis in children who undergo surgery for acute appendicitis. Material and Method: A total of 253 children who underwent surgery for acute appendicitis in our clinic between January 1, 2022, and October 1, 2024, and underwent surgery for acute appendicitis were included in our study. Results: Among the cases, 81% (n=205) were classified in the non-complicated, while 19% (n=48) were in the complicated group. In our analysis, we found that the PNI (p=0.027) and HALP score (p=0.007) were considerably lower in the complicated appendicitis group, whereas the neutrophil-to-lymphocyte ratio (NLR) (p=0.003) and platelet-to-lymphocyte ratio (PLR) (p=0.008) were significantly higher. Correlation analysis revealed a meaningful positive association between PNI and HALP score, a mild unfavorable association between PNI and both PLR and NLR, a strong positive correlation between HALP score and both PLR and NLR and a mild positive relationship between NLR and PLR. Conclusion: PNI, HALP score, NLR, and PLR values measured at the time of admission to the emergency services may serve as potential predictors in differentiating between complicated and non-complicated appendicitis.
Metamizole modulates the concentrations of cytokines and hematopoietic growth factors in an experimental model of depression
(Hatay Mustafa Kemal Üniversitesi Tıp Fakültesi Dekanlığı, 2025) Maytalman, Erkan; Kıroğlu, Olcay; Berktaş, Fatih; Nemutlu Samur, Dilara; Aksu, Fazilet
In recent years, evidence of antidepressant-like activity of non-steroidal anti-inflammatory drugs has been presented. Furthermore, associations between cytokines, which are important components of the immune system, as well as hematopoietic growth factors and depression have also been demonstrated. In this study, it was aimed to analyze the effect of metamizole on the expression of cytokines and hematopoietic growth factors in mice exposed to unpredictable stress models. Method: In order to develop chronic depression behaviors, an unpredictable chronic mild stress model was applied to mice. The depression group was not given any drug and other groups were given 100 and 200 mg/kg metamizole. Forced swimming test was performed to evaluate the effect of metamizole against depression. Relative concentrations of interleukin-1 alpha (IL-1α), IL-1 beta (IL-1-ß), IL-2, IL-4, IL-6, IL-10, IL-12, IL-17, Interferon gamma (IFN-γ)-, tumor necrosis factor-alpha (TNF-α), Granulocyte-colony-stimulating factor (G-CSF), and Granulocyte-macrophage colony-stimulating factor (GM-CSF) were analyzed in serum samples of animals with semi-quantitative ELISA. Results: In the forced swimming test, the immobility time of the depression group significantly increased compared to the control group. The immobility time of groups treated with metamizole significantly decreased compared to the depression group and approached the control. Significant decreases were observed in the relative concentration levels of cytokines and hematopoietic growth factors in the groups treated with 100 and/or 200 mg/kg metamizole compared to the depression group except for IL-1α, IL-4, and IL-10. Conclusion: Evidence showing the contribution of COX enzymes to the pathophysiology of depression is increasing. In this context, the results indicate that metamizole, which can inhibit both isoforms of COX, may cause changes in cytokine levels and hematopoietic growth factors in a depression model. However, more controlled clinical studies are needed.
Data violence in networked environments: a study on user experience
(Ankara Hacı Bayram Veli Üniversitesi, 2025) Kayış, Hasan Hüseyin
In the context of networked environments, communication with other network users can introduce the element of violence into everyday life. In this case, users may encounter data violence in social media applications, which is a form of violence transferred to networked environments. In this study, data violence encountered by users in social media environments is discussed. Identifying the factors that lead to data violence is important in identifying the problem. This study aims to provide a framework for what can be done in the face of these actions that cause serious harm, along with the factors that cause data violence to occur and continue. The complaints of ordinary users about social media environments on an online complaint platform were collected through document analysis and qualitative content analysis was applied to the data. The findings showed that data violence occurs under different categories, from user to user or platform to user. Platforms' solutions to data violence are inadequate. To prevent data violence caused by the technical infrastructure of the platforms, the need for ethical design and ethical operation of the platforms was emphasized and the duties of the authorities were emphasized.
