Aksaray Üniversitesi Kurumsal Akademik Arşivi
DSpace@Aksaray, Aksaray Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Seductive female villains and rhetoricians in The Monk and Zofloya; or, The Moor
(Springer, 2021) Özkan, Hediye
Matthew Lewis's The Monk: A Romance (1796) and Charlotte Dacre's Zofloya; or, The Moor: A Romance of the Fifteenth Century (1806) portray female villains, who deny the value system of patriarchy and religious and social structures of the eighteenth-century society. Although Lewis's purpose of creating Matilda is not to critique the social position of woman, Matilda becomes the symbol of power and a stronger female figure than Dacre's Victoria. Examining the seductive rhetoric, performativity of villainy, and shifting discourse between the protagonists and demonic figures, this article discusses how Matilda establishes and maintains her autonomy over male subjectivity while Victoria's strong feminist traits transform into submissive characteristics.
Cerebral hemorrhage in a dog with immune-mediated hemoiytic anemia and concurrent thrombocytopenia - a case report
(Polskie Towarzystwo Nauk Weterynaryjnych, 2021) Çolakoğlu, Ekrem Çağatay; Haydardedeoğlu, Ali Evren; Alihosseinp, Hadi; Aydemir, E.C.E.
The aim of this case report is to point out the neurological signs, long term management of the case and M R I lesions suggestive of cerebral haemorrhage in a dog with IMHA and concurrent thrombocytopenia. A 3.5-year-old intact female Cocker Spaniel dog was examined for anorexia, weakness, exercise intolerance and two collapse episodes. Based on the diagnostic procedures primary immune mediated hemolytic anaemia concurrent with severe thrombocytopenia were confirmed. The dog remained stable with prednisolone and fluid therapy for 6 weeks. The dog was later referred to emergency service with hemianopia, head tilt and epilepsy-like signs. Brain M R I lesions showed central line deviation, oedema and cerebral haemorrhage. Post-treatment M R I also provided clear evidence of resolution the cerebral haemorrhage. The dog was asymptomatic for 6 months after splenectomy. To the best our knowledge, this is the first fully documented report of cerebral haemorrhage in a dog with immune mediated hemolytic anaemia and thrombocytopenia.
On a (k, µ)-paracontact manifold satisfying some conditions on the projectıve curvature tensor
(Canadian University of Dubai, 2021) Uygun, Pakize; Atçeken, Mehmet
In the present paper, we study the curvature tensors of (k, µ) Paracontact manifold satisfying the conditions P (ξ, Y)˜Z = 0, P (ξ, Y)P = 0, P (ξ, Y)S = 0 and P (ξ, Y)R = 0. According these cases, (k, µ)-Paracontact manifolds have been characterized. We obtain the necessary and sufficient conditions of a (k, µ)-Paracontact manifold to be (η-)Einsteins.
Phytochemicals analysis and some bioactive properties of erica manipuliflora salisb. (ems); antibacterial, antiradical and anti-lipid peroxidation
(Brieflands, 2021) Kavaz Yüksel, Arzu; Dikici, Emrah; Yüksel, Mehmet; Işık, Mesut; Tozoğlu, Fatih; Köksal, Ekrem
In the present study, the phenolic content by using LC MS/MS method, anticholinergic, antioxidant (metal reduction, radical and removal of lipid peroxidation), and antibacterial activities of Erica manipuliflora Salisb. (EMS) extract were determined. The amount of vanillic acid, fumaric acid, catechin hydrate, quercetin, and phloridzin dihydrate were found higher than other compounds. The ethanol extract of the EMS showed an inhibition effect on the Acetylcholinesterase (AChE) enzyme with IC50 value of 0.124 ± 0.008 mg mL-1. Also, this extract of the EMS indicated radical (DPPH and ABTS) scavenging activity (about 20%) and the reducing capacity for Cu(II) and Fe(III) close to trolox, and inhibited the oxidation of linoleic acid with 40.5% at 20 μg mL-1. Antibacterial activity of the extracts was investigated against Staphylococcus aureus, Escherichia coli, and Salmonella Typhimurium using agar disc diffusion and minimum inhibitory concentration (MIC) methods. The EMS extract was found to be effective when used at least 312 mg mL-1 concentration on the pathogenic microorganisms. Consequently, it has an important non-synthetic natural content that can be used in the treatment of many diseases due to its many bioactivities such as anticholinergic, antioxidant (radical removal, lipid peroxidation prevention, etc.) and antibacterial.
The importance of heart rate variability in predicting cardiac autonomic dysfunction in patients with amyotrophic lateral sclerosis
(John Wiley and Sons Inc, 2021) İşcan, Dilek; Karaaslan, Muhammet Buğra; Deveci, Onur Sinan; Akıllı Eker, Rabia; Koç, Filiz
Aim: Amyotrophic lateral sclerosis (ALS) is a progressive disease characterized by degeneration in the upper and lower motor neurons of the corticospinal tract, brain stem, and spinal cord. Recent studies have revealed that the disease does not present solely with motor neuron involvement. Accordingly, the aim of this study is to investigate the presence of cardiac autonomic impairment in patients diagnosed with ALS. Material and Method: A total of 61 patients, who were diagnosed with ALS according to the Revised El Escorial Criteria (R-EEC), were included in this prospective study, in addition to the 29 healthy individuals, who were included in the study as controls. In order to assess the cardiac autonomic involvement, the presence of orthostatic hypotension was investigated, and transthoracic echocardiography and 24-hour electrocardiogram (ECG) using a Holter monitor were performed. Results: Orthostatic hypotension was detected in 14 (22.2%) patients. Holter electrocardiogram results of the patient group revealed statistically significantly lower heart rate variability (HRV) indicators in the time domain (SDNN, SDANN, SDNN index, rMSSD, and pNN50) and in the frequency domain (high frequency [HF], low frequency [LF], and very low frequency [VLF]) than those of the control group (P <.05). Conclusion: Contrary to the popular opinion, cardiac autonomic dysfunction in patients with ALS can occur at any stage of the disease. Therefore, it is recommended that the patients are evaluated via periodic examinations during the follow-up period for cardiac autonomic involvement.
