Characterization of intact chitosan obtained from Bradyporus sp. (Orthoptera, Insecta) and its cytotoxicity on human cell line (HEK293)
| dc.authorid | 0000-0003-1716-5509 | |
| dc.authorid | 0000-0003-1716-5509 | |
| dc.authorid | 0000-0003-0395-1509 | |
| dc.authorid | 0000-0001-6954-2703 | |
| dc.contributor.author | Umran, Rajaa | |
| dc.contributor.author | Mol, Abbas | |
| dc.contributor.author | Mosa, Amal Umran | |
| dc.contributor.author | Kaya, Murat | |
| dc.date.accessioned | 2024-08-05T08:39:43Z | |
| dc.date.available | 2024-08-05T08:39:43Z | |
| dc.date.issued | 2024 | |
| dc.department | Sağlık Bilimleri Fakültesi | |
| dc.description.abstract | Intact chitosan film was produced from Bradyporus sp. (Orthoptera, Insecta) and characterized by Fourier Transform Infrared Spectroscopy (FTIR), Thermogravimetric Analysis (TGA), X-ray diffractometer (XRD), Scanning Electron Microscopy (SEM) and elemental analysis. MTT test was performed to determine the cytotoxic effects of chitosan. Chitosan administered at optimal and overdose intervals was applied to HEK293 cells for 24, 48 and 72 hours. In the MTT cytotoxicity test, the IC50 dose of chitosan was 1427 µM at 24 hours, 808.9 µM at 48 hours, and 611.6 µM at 72 hours. Considering all the conducted analyses and cytotoxic experiments, the obtained intact novel chitosan film from the insects could find applications for biotechnological applications. | |
| dc.identifier.doi | 10.29002/asujse.1382667 | |
| dc.identifier.endpage | 23 | en_US |
| dc.identifier.issn | 2587-1277 | |
| dc.identifier.issue | 1 | en_US |
| dc.identifier.startpage | 16 | en_US |
| dc.identifier.uri | https://doi.org/10.29002/asujse.1382667 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12451/12331 | |
| dc.identifier.volume | 8 | en_US |
| dc.language.iso | en | |
| dc.publisher | Aksaray Üniversitesi | |
| dc.relation.ispartof | Aksaray University Journal of Science and Engineering (ASUJSE) | |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | Attribution-NonCommercial 3.0 United States | * |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/us/ | * |
| dc.subject | Chitin | |
| dc.subject | Chitosan | |
| dc.subject | Phytochemistry | |
| dc.subject | HEK293 | |
| dc.subject | Cytotoxicity | |
| dc.subject | Bradyporus sp. | |
| dc.title | Characterization of intact chitosan obtained from Bradyporus sp. (Orthoptera, Insecta) and its cytotoxicity on human cell line (HEK293) | |
| dc.type | Article |
