The quantification of mitochondria in different synapse types in the prefrontal cortex using stereological techniques
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Tarih
2024
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Nova Science Publishers, Inc.
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The prefrontal cortex (PFC) lies in the anterior part of the brain, constitutes a large part of the central nervous system, and is of great importance to socio-emotional and executive functions crucial to numerous cognitive abilities. This chapter discusses the use of stereological methods for determining the synaptic functions of mitochondria in the PFC region. Stereology is a field involving various methods that permits the interpretation of the three-dimensional characteristics of any three-dimensional structure based on twodimensional images. The use of electron microscopic images of PFC mitochondria (mPFC) structures provides information about the stereological Cavalieri and physical disector applications. These methods are unbiased, effective, reliable, low-cost and repeatable, and increasing repetition makes it possible to obtain results increasingly close to the true values.
Açıklama
Anahtar Kelimeler
Electron Microscopy, Mitochondria, Prefrontal Cortex, Stereology, Synapses
Kaynak
A Manual of the Stereological Techniques
WoS Q Değeri
Scopus Q Değeri
N/A
