Sıçanlara uygulanan sodyum piritionun kan serumu ACTH ve kortikosteron hormon düzeylerine etkisi
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Date
2020
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Publisher
Aksaray Üniversitesi Fen Bilimleri Enstitüsü
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info:eu-repo/semantics/openAccess
Abstract
Bu çalışmada sıçanlar üzerine intraperitonal yolla uygulanan sodyum pirition (35 ve 70 mg/kg, ip) ile tuzlu suyun (salin) (%0,09 NaCl 0,5 ml/kg, ip) 24 ve 96 saatlik sürelerde uygulanmasıyla meydana gelen hormonal etkiler incelendi. Araştırma sonucunda, sıçanlarda sodyum piritionun hormonal adaptasyona dair düzenlemelere yol açtığı tespit edildi. Sodyum pirition, tüm dozaj seviyelerinde 4 gün içinde %85-95 oranında metabolize edilip idrarla atılmıştır. ACTH ve kortikosteron düzeylerinin 96 saat sonunda normale dönme nedeninin bu olabileceği ortaya konmuştur.
In this study, the hormonal effects in rats caused by intraperitoneal administration of sodium pyrithione (35 and 70 mg/kg, ip) and saline (0.09% NaCl 0.5 ml/kg, ip) for 24 and 96 hours were investigated. As a result of the research, it was found that sodium pyrithione caused regulation of hormonal adaptation in rats. Sodium pyrithione was metabolized 85-95% within 4 days at all dosage levels and was excreted in the urine. It has been demonstrated that this may be the reason why ACTH and corticosterone levels return to normal after 96 hours.
In this study, the hormonal effects in rats caused by intraperitoneal administration of sodium pyrithione (35 and 70 mg/kg, ip) and saline (0.09% NaCl 0.5 ml/kg, ip) for 24 and 96 hours were investigated. As a result of the research, it was found that sodium pyrithione caused regulation of hormonal adaptation in rats. Sodium pyrithione was metabolized 85-95% within 4 days at all dosage levels and was excreted in the urine. It has been demonstrated that this may be the reason why ACTH and corticosterone levels return to normal after 96 hours.
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Keywords
Sodyum Pirition, ACTH, Kortikosteron, Sıçan, Sodium Pyrithione, Corticosterone, Rat
