Prediction of treatment efficacy in psoriasis vulgaris using dermoscopic and capillaroscopic findings: a prospective cohort study

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dc.contributor.authorReşat Akkuş, Muhammet
dc.contributor.authorÖzyurt, Kemal
dc.contributor.authorAtasoy, Mustafa
dc.contributor.authorErtas, Ragıp
dc.contributor.authorKulu, Huzeyfe
dc.contributor.authorÖzata, Sinem Sogancıoğlu
dc.contributor.authorDemirbaş, Abdullah
dc.contributor.authorFaruk Elmas, Ömer
dc.contributor.authorDiremsizoğlu, Esin
dc.date.accessioned2025-09-23T07:47:51Z
dc.date.available2025-09-23T07:47:51Z
dc.date.issued2025
dc.departmentTıp Fakültesi
dc.description.abstractPsoriasis is a chronic inflammatory skin disorder affecting millions worldwide. Dermoscopy and proximal nailfold capillaroscopy have emerged as valuable tools for understanding the pathophysiology and treatment response of psoriasis lesions.ObjectivesThis study aimed to contribute to the limited literature on using dermoscopic findings to detect treatment effectiveness in patients with psoriasis vulgaris.MethodsThis prospective, single-blinded, observational cohort study included 101 patients aged 18-71 years diagnosed with psoriasis vulgaris who initiated or altered systemic treatment. Monthly dermoscopic and capillaroscopic evaluations were performed alongside assessments of Psoriasis Area Severity Index (PASI), Body Surface Area (BSA), and Dermatology Life Quality Index (DLQI) scores.ResultsA significant relationship was found between first-month dermoscopic findings and third-month severity scores (PASI, BSA, DLQI). Patients with positive treatment responses exhibited changes from baseline regular capillary dilations to hemorrhagic spots or the absence of vascular findings during the first month. The correlations between dermoscopic changes and severity scores evolved over time, becoming stronger in the second and third months. Nailfold capillaroscopy findings at the third month of treatment showed significant differences from baseline.ConclusionsDermoscopy is a fast, practical, and inexpensive tool for early prediction of treatment effectiveness in psoriasis vulgaris. The disappearance of regular capillary dilations or their change to hemorrhagic spots suggests treatment efficacy, while their persistence indicates poor treatment response. Early detection of treatment effectiveness using dermoscopic findings can facilitate timely adjustments, improving patient outcomes and reducing unnecessary treatment exposure.
dc.identifier.doi10.1007/s00403-024-03701-x
dc.identifier.issue1
dc.identifier.urihttps://doi.org/10.1007/s00403-024-03701-x
dc.identifier.uri0340-3696 / 1432-069X
dc.identifier.urihttps://hdl.handle.net/20.500.12451/14519
dc.identifier.volume317
dc.identifier.wosWOS:001397238800002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.institutionauthorKulu, Huzeyfe
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofArchives of Dermatological Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPsoriasis Vulgaris
dc.subjectDermoscopy
dc.subjectCapillaroscopy
dc.subjectMicrocirculation
dc.titlePrediction of treatment efficacy in psoriasis vulgaris using dermoscopic and capillaroscopic findings: a prospective cohort study
dc.typeArticle

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