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Öğe Multifunctional mesoporous silica-based nanocomposites for biomedical applications(Elsevier, 2025) Shcharbin, Dzmitry; Önal Acet, Burcu; Halets-Bui, Inessa; Odabaşı, Mehmet; Acet, ÖmürRecently, there has been a notable interest in mesoporous silica nanostructures (MSNs) owing to their highly advantageous structural characteristics. MSNs possess significant characteristics, including a substantial internal surface area and pore volume, adjustable pore sizes, excellent colloidal stability, and the ability to modify the functionality of both the internal pore system and external particle surface. Due to these significant characteristics, MSNs have emerged as a highly up-and-coming and extensively adaptable platform for biomedical implementations. MSNs have attracted significant attention in the field of integrated nanocomposite systems due to their remarkable properties, such as low cytotoxicity, excellent chemical stability, and having an easily modifiable surface. In this book chapter, we discussed some silica structures, their properties, designs, and the importance of silica structures for biomedical applications, and also touched upon their applications in the biomedical field in recent years. And also, in addition to the MCM-41, SBA-15, FDU, and KIT series structures, which are silica-based nanostructures, different silica nanostructures are also mentioned. Also, current studies are included, especially those that have been carried out in recent years.Öğe Biomedical applications of multifunctional polymer based nanostructured coatings(Elsevier, 2025) Acet, Burcu Önal; Shcharbin, Dzmitry; Halets-Bui, Inessa; Odabaşı, Mehmet; Acet, ÖmürPolymer-based nanomaterials (PNMs) are becoming increasingly crucial in transforming the detection and management of diseases. PNMs have emerged as extremely important components in the diagnosis and treatment of diseases. Various properties of PNMs, such as shape, size, stability, surface charge, mechanical strength, surface chemistry, and porosity, can be tailored to meet the specific requirements of biomedical applications. Polymeric coatings are highly adaptable techniques for modifying surfaces and possess great promise for use in the field of biomedicine. Especially, the application of polymer coatings on solid materials is of great importance in the field of biomedical science. In this book chapter, we will cover the review of important multifunctional PNMs, their coatings, and applications. And also, we will touch upon important factors to consider during designThe objective of this chapter is to explore the most recent advancements and potential future opportunities in the realm of universal polymer coatings and their applications in the field of biomedicine.Öğe An insight into the potential contaminants, their effects, and removal means(Elsevier, 2022) Gürbüz, Fatma; Odabaşı, MehmetThere are numerous and ubiquitous chemicals from different sources threatening the environment we live in throughout the world. These contaminants belong to many groups including inorganics i.e., metal/metalloid ions or organic contaminants such as plastics, polycyclic aromatic hydrocarbons (PAHs), and pharmaceutical and personal care products (PPCPs). Additionally, biological, and radiological agents must not be forgotten. These pollutants have many direct or indirect effects on the environment and human health. Therefore, there is a great need to remove these contaminants from the relevant areas. Removal methods of contaminants from the environment can vary depending on the nature, quantity and magnitude of pollutants. This chapter focuses on different type of contaminants which may cause adverse ecological and/or human health effects and their removal methods.Öğe Future aspects of sports medicine(Nova Science Publishers, Inc., 2021) Uyar, T.; Bozdoğan, B.; Denkbaş, E.B.Sports medicine is a medical field concerned with physical fitness, treatment, and prevention of injures related to sports and exercise. The sports medicine physicians are constantly looking for treatment options that can successfully treat these injuries while minimizing time away from the sport and preventing return. The most common sports injuries in treatment studies include fractures, concussion, patellar tendonitis, anterior cruciate ligament (ACL) tears, knee cartilage injures, meniscal tears, shoulder separation, nerve compression injuries, posterior cruciate ligament (PCL) injuries, shoulder dislocation, sprains and strains, tennis elbow - lateral epicondylitis and tendonitis and more. In literature, there are many studies on various approaches (surgical and non-surgical) used in the treatment of the mentioned injuries. However, the validity of traditional methods is decreasing day by day, new generation and futuristic solutions are needed more. It is quite clear that innovative approaches (such as nanomedicine, smart-materials with personalized pharmaceutical and nutritional technologies etc.) should be preferred to overcome this deprivation. In this chapter, future aspects of sports medicine and their applications will be discussed.Öğe Molecularly imprinted polymers as a tool for biomolecule separation(Elsevier, 2017) Andaç, Müge; Baydemir, Gözde; Denizli, AdilThe publications in molecularly imprinted materials have increased drastically in recent years, with the development of polymerization systems. The memory in shape, interaction and size of binding cavities has allowed the use of these materials within different applications, particularly in affinity purification and separation in chromatography, sample preparation, and detection in biosensors. Due to their high selectivity, specificity, efficient mass transfer and good reproducibility, molecularly imprinted materials have become attractive for researchers in biomolecular and biomacromolecular recognition. In this review, the recent developments of molecularly imprinted materials in affinity separation and purification systems are reviewed comprehensively. Some significant applications were also highlighted for further investigation.Öğe An anomalous addition of chlorosulfonyl isocyanate to a carbonyl group: the synthesis of ((3aS, 7aR, E)-2-ethyl-3-oxo-2,3,3a, 4,7,7a-hexahydro-1H-isoindol-1-ylidene)sulfamoyl chloride(Beilstein-Institut, 2019) Köse, Aytekin; Ünal, Aslı; Şahin, Ertan; Bozkaya, UĞur; Kara, YunusIn this study, we developed a new addition reaction of chlorosulfonyl isocyanate (CSI), starting from 2-ethyl-3a, 4,7,7a-tetrahydro-1H- isoindole-1,3(2H)-dione. The addition reaction of CSI with 2-ethyl-3a, 4,7,7a-tetrahydro-1H-isoindole-1,3(2H)-dione resulted in the formation of ylidenesulfamoyl chloride, whose exact configuration was determined by X-ray crystal analysis. We explain the mechanism of product formation supported by theoretical calculations.Öğe Surface plasmon resonance sensors for medical diagnosis(Springer Berlin Heidelberg, 2018) Yeşeren, Saylan; Yılmaz, Fatma; Özgür, Erdoğan; Derazshamshir, Ali; Bereli, Nilay; Yavuz, Handan; Denizli, Adil[No abstract available]
