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Öğe Nanobiosensors for mycotoxins detection in foodstuff: Qualitative and quantitative assessments(Elsevier, 2024) Çalışır, Merve; Özgür, Erdoğan; Çimen, Duygu; Topçu, Aykut Arif; Erkek, Muhammed; Bereli, Nilay; Denizli, AdilMycotoxins are naturally toxic compounds with low molecular weight and formed as a result of the secondary metabolism of fungi (mold) species. Since they are harmful to many living organisms, cost-effective, sensitive, and reliable detection methods are crucial for preventing the unwanted side effects of these toxic metabolites. Enzyme-linked immunoassay (ELISA), chromatographic methods like thin layer chromatography (TLC), and biosensors are often used as analytical approaches for the detection of mycotoxins. In this context, we summarized the traditional methods for mycotoxin detection and focused on the potential use of nanobiosensor platforms for mycotoxin sensing in foodstuffs.Öğe MXenes and Its Composites for Biomedical Applications(Wiley, 2024) Topçu, Aykut Arif; Kılıç, Seçkin; Denizli, AdilMXenes, referred to as 2D emerging materials from the transition metal carbides, nitrides, or carbonitrides family, have taken the attention of the scientific community since 2011 because of having unique features, for instance, biocompatibility, high hydrophilicity, mechanical, electrical, optical, and antibacterial properties, as well as photothermal conversion efficiency (PCE), large surface area, and so on. Due to the combination of their versatile chemistry and tunable properties, MXenes play a crucial role in various fields e.g. electrocatalysis, energy storage, corrosion protection, electromagnetic, optical, electronic, and high-temperature structural applications. Furthermore, ease of the surface modification of these emerging materials with the biomolecules, nanoparticles, and quantum dots can enhance the superior features of MXenes and make them favorable materials used in various biomedical applications and bioimaging. The new generation of 2D materials has paved way the for biosensor studies, including wearable biosensing platforms, point-of-care devices, theranostics, photothermal therapy of cancer, drug delivery studies, and antibacterial applications. In this context, we first introduce the basic properties, unique features, and preparation protocols of MXene and its composites. After that, we highlighted the possible use of MXenes and their composites for different biomedical applications with recent and relevant research articles.Öğe The key concepts of plasmonic nanosensors(CRC Press, 2024) Topçu, Aykut Arif; Özbek, Merve Asena; Yılmaz, Gaye Ezgi; Denizli, AdilBiosensors are the focus of much attention from the scientists and these systems, which are the center oof various scientific communities are employed to improve the quality of human life. One of these platforms, plasmonic nanosensors with sensitivity, real-time monitoring, and label-free sensing capability make them as promising platforms utilized in various fields. In the first part of this section, we introduce the general concept of plasmonics and a short brief of surface plasmon theory. Following that, the key features of plasmonic nanoparticles, their fabrication processes, and their positive effects on sensing systems are discussed. In the second part, the key concepts of surface plasmon resonance (SPR), localized surface plasmon resonance (LSPR), propagating surface plasmon resonance (PSPR), and surface-enhanced raman scattering (SERS)-based sensors are summarized and finally, the sensing capabilities of these plasmonic nanosensors for biomedical application, agricultural studies, and warfare threats are discussed using relevant articles.Öğe Information ethics in the context of current developments(IGI Global, 2023) Esmer, Yusuf; Arıbaş, Ayşe NihanThe emergence of globalization due to information technologies and the changes and/or developments brought about by globalization require organizations to have more knowledge about ethics and therefore to be more interested in this issue. The use of information and communication technologies in organizations in accordance with ethical values is considered important in terms of the integrity, functioning, and efficiency of both employees and organizations. Individuals, managers, organizations, and researchers have important duties in the field of information ethics in order to prevent the making of difficult mistakes that will adversely affect individuals and organizations during the use of information technologies. In this context, information ethics has been examined in this study in the context of recent developments all over the world, especially the developments in the global COVID-19 pandemic process.Öğe Conducting polymers for gene delivery(CRC Press, 2022) Topçu, Aykut Arif; Özgür, Erdoğan; Denizli, AdilGene therapy is an alternative approach to insert the gene into a patient's cell to treat various diseases such as cancer, inherited disorders, and viral infections instead of using drugs or operations. For this aim, the viral and nonviral vectors are used in gene delivery studies and the nonviral vectors received significant attention because of simplicity, low-immune response, and controllability. Conducting polymers (CPs) known as Nobel Prize winner materials with unique features such as ease of synthesis, in vivo and in vitro biocompatibility, electric conductivity are promising materials for wide applications, e.g., biosensor platforms, photocatalytic applications, and biomedical studies. Furthermore, depending on the redox state, the molecules could be entrapped or released by applying the electrical stimulation; so, these conjugated polymers are also potentially used in gene delivery studies. In this context, the widely used CPs, their chemical synthesis, their interactions with DNA, siRNA, their entry into the cells, and their gene delivery performances are highlighted.Öğe Bacterial cellulose nanofibers for separation, drug delivery, wound dressing, and tissue engineering applications(Elsevier, 2022) Tamahkar, Emel; Topçu, Aykut Arif; Perçin, Işık; Aslıyüce, Sevgi; Denizli, AdilBacterial cellulose (BC) nanofibers with high purity, high surface/volume ratio, high biocompatibility, high porosity, high tensile strength, and high water holding capacity are emerging attractive biomaterial. BC nanofibers can be prepared simply via bacterial incubation withalow cost inadetermined shape owing to its in-situ moldability. BC nanofibers due to its structural and morphological properties have demonstrated great potential asanative form or with various modifications using polymers, micro/nanoparticles, and small molecules for diverse application areas. This review aims to discuss the applicability and efficiency of the BC nanofibers and its composites focusing on the unique characteristics of BC in the fields of separation, drug delivery, wound dressing, and tissue engineering. It overviews the recent developments about the fabrication methods of BC that was used asaseparation medium, adrug delivery vehicle, awound dressing material, andascaffold.
