Yazar "Pesyan, Nader Noroozi" seçeneğine göre listele

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  • Küçük Resim
    Öğe
    4-Methylmorpholinium bis-(thio)barbiturates: Synthesis, structure, anticancer evaluation, andCoMFAstudy
    (Wiley-VCH, 2020) Pesyan, Nader Noroozi; Rashidnejad, Hamid; Esmaeili, Mohammad Ali; Safari, Elnaz; Tunç, Tuncay; Alilou, Mostafa; Safavi-Sohi, Reihaneh; Şahin, Ertan
    The reaction of symmetrical (thio)barbituric acids with aldehydes in the presence of 4-methyl morpholine yielded a new form of 4-methyl morpholinium bis-(thio)barbiturate containing charge-separated intermolecular and eight-membered intramolecularH-bonds. X-ray Crystallography, FT-IR, and(1)H and(13)C-NMR spectroscopy techniques were used for structure characterizations. Some of these compounds showed potent anticancer activities. Cytotoxicity of the synthetic compounds against HeLa and MCF-7 cell lines were performed by MTT assay. In addition, a comparative molecular field analysis was carried out, and the effects of substituents on the biological activities of these compounds were explained.
  • [ X ]
    Öğe
    New fatty acid derivatives based on barbiturates and other cyclic beta-dicarbonyl compounds and an acyl migration
    (Springer, 2014) Pesyan, Nader Noroozi; Bagheri, Marziyeh; Sahin, Ertan; Tunç, Tuncay
    The use of DCC, triethylamine and 4-dimethylaminopyridine in dichloromethane provides a general and standard one-pot procedure for the O-acylation of cyclic beta-dicarbonyl compound derivatives (1) with palmitic and stearic acids which have long hydrocarbon tails, to synthesis of new type of fatty acid derivative in good to excellent yields. Structure elucidation was carried out by FT-IR, H-1 NMR and C-13 NMR spectroscopy techniques. The acyl migration was also found in results and the corresponding structure was characterized by X-ray crystallography. A proposed mechanism was discussed for the formation of products.
  • Küçük Resim
    Öğe
    Regioselective one-pot synthesis of new unsymmetric spiro dihydrofurans in the reaction of mixed two different cyclic ?-dicarbonyl compounds with BrCN and aldehydes in the presence of Et3N
    (WILEY-V C H VERLAG GMBH, 2015) Pesyan, Nader Noroozi; Shokr, Alireza; Gharib, Ali; Tunç, Tuncay; Şahin, Ertan
    Crossed one-pot reaction of mixed cyclic beta-dicarbonyl with various aldehydes in the presence of cyanogen bromide and triethylamine leads to the selective and efficient formation of crossed new unsymmetrical spiro dihydrofurans at room temperature. The products were obtained in good to excellent yields. Structure elucidation was carried out by H-1 NMR, C-13 NMR, FT-IR spectroscopy, Mass analyses and X-ray crystallography technique. A proposed mechanism was discussed for the formation of products.
  • Küçük Resim
    Öğe
    Synthesis of Bis-spiro Cyclopropanes Based on Meldrum's Acid by Milling
    (Wiley-Blackwell, 2015) Kashani, Elmira; Pesyan, Nader Noroozi; Tunç, Tuncay; Şahin, Ertan
    Reaction of 2,2-dimethyl-1,3-dioxane-4,6-dione (Meldrum's acid) with various solid aldehydes in the presence of cyanogen bromide and solid sodium ethoxide (EtONa) leads to the selective and efficient formation of bis-spiro cyclopropanes based on Meldrum's acid at the range of 0 degrees C to room temperature. The products were obtained in good to excellent yields. Structure elucidation is carried out by H-1 NMR, C-13 NMR, FT-IR spectroscopy, mass analyses and X-ray crystallography techniques. A possible mechanism for the formation of products is also discussed under solvent-free condition.