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    C-reactive protein to albumin ratio as a prognostic predictor in larynx cancer
    (İstanbul Bağcılar Eğitim ve Araştırma Hastanesi, 2020) Cengiz, Abdurrahman; Gümüşlü, Bekir Can; Kayabaşı, Serkan; Tansuker, Hasan Deniz; Öğreden, Şahin; Oktay, Mehmet Faruk
    During the past decade, several inflammation-based prognostic systems have been reported in the field of clinical oncology. Recently, C-reactive protein and albumin ratio (CAR) have showed their impact on a large variety of tumor types. The aim of this study is to evaluate the impact CAR on prognosis and 5-year survival (5yS) in patients operated for larynx cancer. Method: One hundred eighteen patients operated in our center between 2010 and 2015 were eligible for retrospective analysis. We evaluated the impact of the CAR and neutrophil to lymphocyte ratio (NLR) on the 5yS. Univariate and multivariate Cox regression analyses were performed to determine the associations of CAR. Results: The optimal cut-off level of CAR was at 0.993. A low and high CAR was assigned to 40.7% and 59.3% of patients, respectively. The 5yS rates of patients with a high CAR were worse than those in the low group (79.2% vs 73.2% p<0.05). Disease stage (p<0.001) and high level of NLR were also significant predictors of 5yS. CAR at diagnosis was associated with an unfavorable progress. Patients with stage III-IV disease had a significantly higher pretreatment CAR than patients with stage I-II disease [respectively 1.83±0.52 standard deviation (SD) and 0.58±0.38 (SD), p<0.01]. ROC analysis of overall survival of larynx squamous cell carcinoma revealed that CAR had a greater area under curve value (0.786) compared to NLR (0.695) (p<0.01). Conclusion: CAR is an independent prognostic marker in larynx cancer after being adjusted by other accompanying factors and the CAR could be a readily available biomarker in clinical setting.
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    Effects of oral sotretinoin on normal and wounded nasal mucosa: An experimental study
    (Springer, 2018) Cengiz, Abdurrahman Buğra; Özyılmaz, Cemal; Tabaru, Alper; Kayabaşı, Serkan; Ege, Sertuğ Sinan; Rüzgar, Sedat; Emre, Funda; Oktay, Mehmet Faruk
    BackgroundWe aimed to investigate the effect of systemic isotretinoin therapy on normal and wounded nasal septal mucosa histopathologically in an experimental rabbit model.MethodsCircular mucosal defect with a 7mm diameter was made in the left septum of 12 New Zealand white rabbits. The rabbits were divided into two groups (six rabbits in each group) oral isotretinoin was given with olive oil at the operation day to the first group. The control group was only oil given group. The harvested septum mucosas were divided into four groups (1wounded-drug given side, 2unwounded and drug-given side, 3wounded-control and 4unwounded-control side). The diameter of the defect, mucosal thickness, epithelial thickness, ciliated cell level, goblet cell level and inflammation were evaluated every week for 4weeks.ResultsAt both wounded and normal side, thinning of normal respiratory ciliated epithelium was observed in the postoperative period. In study group at the wounded side; mean mucosal thickness was measured 139.66 mu (26.24), and in the control group, mean mucosal thickness was 238.33 mu (+/- 39.7) at the wounded side. (p<0.001). The difference between the groups in thickness of normal septal mucosa was also statistically significant (p=0.016) [190 mu (+/- 14.6) and 256.66 mu (+/- 44.66)]. The average cilia level was observed 1.16 in the wounded study group, while the average level was 2.33 in the wounded control group (p=0.012). Average score measurements of the regenerated mucosa suggested that isotretinoin-given wounded animals have reduced goblet cell recovery, compared to the control both on the regenerated and unwounded mucosas (p=0.007, p=0.002, respectively). Inflammation was significantly higher in the wounded isotretinoin group (p=0.018).Conclusion Oral isotretinoin has negative effects on epithelial and ciliary regeneration, significantly reduces mucosal thickness and goblet cell counts of the normal and regenerated mucosa, causes severe inflammation and significant reactive changes.