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    4-Methyl morpholinium bis-(thio)barbiturates: Synthesis, structure, anticancer evaluation, and CoMFA study
    (Chinese Chemical Society Taiwan, 2020) Noroozi Pesyan, Nader; Rashidnejad, Hamid; Safari, Elnaz; Tunç, Tuncay; Alilou, Mostafa; Safavi-Sohi, Reihaneh; Şahin, Ertan; Esmaeili, Mohammad Ali
    The reaction of symmetrical (thio)barbituric acids with aldehydes in the presence of 4-methyl morpholine yielded a new form of 4-methyl morpholinium bis-(thio)barbiturate containing charge-separated intermolecular and eight-membered intramolecular H-bonds. X-ray Crystallography, FT-IR, and 1H and 13C-NMR spectroscopy techniques were used for structure characterizations. Some of these compounds showed potent anticancer activities. Cytotoxicity of the synthetic compounds against HeLa and MCF-7 cell lines were performed by MTT assay. In addition, a comparative molecular field analysis was carried out, and the effects of substituents on the biological activities of these compounds were explained.