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    Biomedical applications of multifunctional polymer based nanostructured coatings
    (Elsevier, 2025) Acet, Burcu Önal; Shcharbin, Dzmitry; Halets-Bui, Inessa; Odabaşı, Mehmet; Acet, Ömür
    Polymer-based nanomaterials (PNMs) are becoming increasingly crucial in transforming the detection and management of diseases. PNMs have emerged as extremely important components in the diagnosis and treatment of diseases. Various properties of PNMs, such as shape, size, stability, surface charge, mechanical strength, surface chemistry, and porosity, can be tailored to meet the specific requirements of biomedical applications. Polymeric coatings are highly adaptable techniques for modifying surfaces and possess great promise for use in the field of biomedicine. Especially, the application of polymer coatings on solid materials is of great importance in the field of biomedical science. In this book chapter, we will cover the review of important multifunctional PNMs, their coatings, and applications. And also, we will touch upon important factors to consider during designThe objective of this chapter is to explore the most recent advancements and potential future opportunities in the realm of universal polymer coatings and their applications in the field of biomedicine.
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    Dipeptide nanostructures: Synthesis, interactions, advantages and biomedical applications
    (Elsevier, 2023) Ömür, Acet; Shcharbin, Dzmitry; Zhogla, Victoriya; Kirsanov, Pavel; Halets-Bui, Inessa; Önal Acet, Burcu; Gök, Tuba; Bryszewska, Maria; Odabaşı, Mehmet
    Short peptides are important in the design of self-assembled materials due to their versatility and flexibility. Self-assembled dipeptides, a group of peptide nanostructures, have highly attractive uses in the field of biomedicine. Recently these materials have proved to be important nanostructures because of their biocompatibility, low-cost and simplicity of synthesis, functionality/easy tunability and nano dimensions. Although there are different studies on peptide and protein-based nanostructures, more information about self-assembled nanostructures for dipeptides is still required to discover the advantages, challenges, importance, synthesis, interactions, and applications. This review describes and discusses the self-assembled dipeptide nanostructures especially for biomedical applications.
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    First protein affinity application of Cu2+-bound pure inorganic nanoflowers
    (Springer, 2022) Önal, Burcu; Acet, Ömür; Dzmitruk, Volha; Halets-Bui, Inessa; Shcharbin, Dzmitry; Özdemir, Nalan; Odabaşı, Mehmet
    Today, a new kind of materials is introduced to separation media day by day to increase the efficiency of the separation processes, and multiple-petalled nanostructured materials are one of them. In this study, new pure inorganic copper phosphate nanoflowers (pCP-NFs) were synthesized, and some environmental conditions affecting on binding mechanism with human serum albumin were evaluated via changing medium pH, temperature, initial human serum albumin (HSA) amount and salt concentrations. Before experimental studies, pCP-NFs were subjected to some characterization tests such as scanning electron microscopy, energy-dispersive X-ray, X-ray diffraction and Fourier transform infrared spectroscopy. Besides a lot of valuable instrumental data, some obtained experimental ones as follows: after Cu2+ ions attachment to pCP-NFs as ligand, maximum HSA adsorption capacity of obtained Cu2+-pCP-NFs was found as 225.7 mg/g with an initial concentration of 1.5 mg/mL at pH 7 and 25 degrees C. Langmuir and Freundlich adsorption equations were evaluated for determination of appropriate adsorption model in interaction, and Langmuir model found as the fittest one with a R-2 of 0.9949 was also reviewed to determine Gibbs free energy between HSA and Cu2+-pCP-NFs interaction.
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    Multifunctional mesoporous silica-based nanocomposites for biomedical applications
    (Elsevier, 2025) Shcharbin, Dzmitry; Önal Acet, Burcu; Halets-Bui, Inessa; Odabaşı, Mehmet; Acet, Ömür
    Recently, there has been a notable interest in mesoporous silica nanostructures (MSNs) owing to their highly advantageous structural characteristics. MSNs possess significant characteristics, including a substantial internal surface area and pore volume, adjustable pore sizes, excellent colloidal stability, and the ability to modify the functionality of both the internal pore system and external particle surface. Due to these significant characteristics, MSNs have emerged as a highly up-and-coming and extensively adaptable platform for biomedical implementations. MSNs have attracted significant attention in the field of integrated nanocomposite systems due to their remarkable properties, such as low cytotoxicity, excellent chemical stability, and having an easily modifiable surface. In this book chapter, we discussed some silica structures, their properties, designs, and the importance of silica structures for biomedical applications, and also touched upon their applications in the biomedical field in recent years. And also, in addition to the MCM-41, SBA-15, FDU, and KIT series structures, which are silica-based nanostructures, different silica nanostructures are also mentioned. Also, current studies are included, especially those that have been carried out in recent years.
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    Synthesis, characterization and anticancer effect of doxorubicin-loaded dual stimuli-responsive smart nanopolymers
    (Beilstein-Institut, 2024) Acet, Ömür; Kirsanov, Pavel; Acet, Burcu Önal; Halets-Bui, Inessa; Shcharbin, Dzmitry; Cömert, Seyda Ceylan; Odabaşı, Mehmet
    Nanopolymers represent a significant group of delivery vehicles for hydrophobic drugs. In particular, dual stimuli-responsive smart polymer nanomaterials might be extremely useful for drug delivery and release. We analyzed the possibility to include the known antitumor drug doxorubicin (DOX), which has antimitotic and antiproliferative effects, in a nanopolymer complex. Thus, doxorubicin-loaded temperature- and pH-sensitive smart nanopolymers (DOX-SNPs) were produced. Characterizations of the synthesized nanostructures were carried out including zeta potential measurements, Fourier-transform infrared spectroscopy, and scanning electron microscopy. The loading capacity of the nanopolymers for DOX was investigated, and encapsulation and release studies were carried out. In a final step, the cytotoxicity of the DOX-nanopolymer complexes against the HeLa cancer cell line at different concentrations and incubation times was studied. The DOX release depended on temperature and pH value of the release medium, with the highest release at pH 6.0 and 41 degrees C. This effect was similar to that observed for the commercial liposomal formulation of doxorubicin Doxil. The obtained results demonstrated that smart nanopolymers can be efficiently used to create new types of doxorubicin-based drugs.
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    Synthesis, Characterization, and Investigation of Corona Formation of Dipeptide-Based Nanomaterials
    (Multidisciplinary Digital Publishing Institute (MDPI), 2025) Dikici, Emrah; Önal Acet, Burcu; Bozdoğan, Betül; Acet, Ömür; Halets-Bui, Inessa; Shcharbin, Dzmitry; Odabaşı, Mehmet
    Peptide-based nanomaterials can be easily functionalized due to their functional groups, as well as being biocompatible, stable under physiological conditions, and nontoxic. Here, diphenylalanineamide-based nanomaterials (FFANMs) were synthesized, decorated with Ca2+ ions to set the surface charge, and characterized for possible use in gene delivery and drug release studies. FFANMs were characterized by SEM, TEM, dynamic light scattering (DLS), and LC-MS/MS. Corona formation and biocompatible studies were also carried out. Some of the data obtained are as follows: FFANMs have a diameter of approximately 87.93 nm. While the zeta potentials of FFANMs and Ca2+@FFANMs were −20.1 mV and +9.3 mV, respectively, after corona formation with HSA and IgG proteins, they were shifted to −7.6 mV and −3.7 mV, respectively. For gene delivery studies, zeta potentials of Ca2+@FFANMs and DNA interactions were also studied and found to shift to −9.7 mV. Cytotoxicity and biocompatibility studies of NMs were also studied on HeLa and HT29 cell lines, and decreases of about 5% and 10% in viability at the end of 24 h and 72 h incubation times were found. We think that the results obtained from this study will assist the groups working in the relevant field. © 2024 by the authors.