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    Biomedical applications of layer-by-layer self assembly
    (Nova Science Publishers, Inc., 2020) Bozdoğan, Betül; Daban, Gizem; Denkbaş, Emir Baki
    Layer-by-layer (LbL) self-assembly is the most widely used strategy for the production of functional surfaces with tailored structures and properties such as chemical, biological, optical and electrical. This strategy involves alternately coating the planar or colloidal surfaces with complementary compounds such as oppositely charged polyelectrolytes, inorganic molecules, metal oxides, silica colloids, dyes, clays, nanostructures or biologically active species like enzymes, DNA, viruses, or proteins. The assembly process is driven by noncovalent interactions under mild conditions. LbL is independent of the substrate shape, size or type; environmentally-friendly; high loading capacity of different types of biomolecules into films; allows room temperature processing and low-cost manufacturing. These outstanding advantages of LbL self-assembly make it especially attractive in the biomedical applications. LbL approaches open new horizon for design biocompatible, antimicrobial, hydrophobic, hydrophilic, electrically conductive, chemically stable, hydrolyzable, adhesive, non-adhesive, anti-thrombotic, semipermeable, stimuli-sensitive surfaces and for loading bioactive molecules to design tissue scaffolds, cardiovascular devices, implants, wound healing dressing, bone grafts, biosensors, drug delivery, and release systems.
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    Öğe
    Porous polyurethane film fabricated via the breath figure approach for sustained drug release
    (Wiley, 2019) Daban, Gizem; Bayram, Cem; Bozdoğan, Betül; Denkbaş, Emir Baki
    The breath figure (BF) method is an effective process for fabricating porous polymeric films. In this study, we fabricated porous polymer films from thermoplastic polyurethane (PU) through static BF with CHCl3 as a solvent under 55-80% relative humidity. The porous PU films were prepared within various pore structures and sizes, which were adjustable, depending on the fabrication conditions. The humidity and exposure time were examined as variable parameters affecting the surface morphology, wettability, and cytotoxicity. Atorvastatin calcium, a hyperlipidemic agent, was loaded into the porous films during the casting process, and the drug-loading and drug-releasing behaviors of the porous PU membranes were evaluated. Approximately 60-80% of the drug was released in 14 days. The films exhibited sustained drug-release performances because of the hydrophobicity and nonbiodegradable nature of PU for perivascular drug administration.