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Öğe Gold nanoparticles loaded TNF-? and CALNN peptide as a drug delivery system and promising therapeutic agent for breast cancer cells(Taylor and Francis Ltd., 2022) Jabir, Majid S.; Abood, Noor A.; Jawad, Marwa H.; Öztürk, Kamile; Kadhim, Haider; Albukhaty, Salim; Al-Shammari, Ahmed; AlMalki, Faizah A.; Albaqami, Jawaher; Sulaiman, Ghassan M.We investigated the anti-cancer properties of gold nanoparticles loaded TNF- and CALNN peptides, which we proposed as a potential drug delivery system using in vitro and in vivo models. The binding of GNPs-TNF- and GNPs-TNF-CALNN was characterized using a UV, ELISA and SEM analysis. The outcomes demonstrated that a novel drug delivery system had an anti-proliferative activity against breast cancer cell lines through a mechanism of apoptosis induction. In vivo model involved studying the cytotoxic influence of a drug delivery system GNPs, GNPs-TNF-? and GNPs-TNF-?-CALNN when applied to the transplanted AN-3 cell line. tumor sections were examined using microarray. In-vivo studies demonstrated that GNPs alone had less of a growth inhibitory effect on tumors implanted in mice when compared to GNPs-TNF–CALNN combined therapy. The cytotoxic assay showed that GNPs, GNPs-TNF-? and GNPs-TNF-?-CALNN exhibit selective toxicity towards cancer cells, inducing cell apoptosis through activation of caspase-3 and 7, p53 protein.
