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Zingerone reduces sodium arsenite-induced nephrotoxicity by regulating oxidative stress, inflammation, apoptosis and histopathological changes

Akaras, Nurhan; Gür, Cihan; Küçükler, Sefa; Kandemir, Fatih Mehmet (Elsevier, 2023)

Arsenic is widely available in the environment and arsenic toxicity is a public health problem of serious concern worldwide. Zingerone is a promising phytochemical with various pharmacological effects. In this study, the ...

Effect of syringic acid on oxidative stress, autophagy, apoptosis, inflammation pathways against testicular damage induced by lead acetate.

Akarsu, Serkan Ali; Gür, Cihan; İleritürk, Mustafa; Akaras, Nurhan; Küçükler, Sefa; Kandemir, Fatih Mehmet (Elsevier GmbH, 2023)

Heavy metals are one of the environmental pollutants. Lead (Pb) is one of the most common of these heavy metals. In this study, it was aimed at investigating the effects of syringic acid (SA) against testicular toxicity ...

Beneficial effects of Chrysin on Cadmium-induced nephrotoxicity in rats: Modulating the levels of Nrf2/HO-1, RAGE/NLRP3, and Caspase-3/Bax/Bcl-2 signaling pathways

Şimşek, Hasan; Akaras, Nurhan; Gür, Cihan; Küçükler, Sefa; Kandemir, Fatih Mehmet (Elsevier B.V., 2023)

Cadmium (Cd) is a toxic heavy metal that targets the kidney directly in the body. Chrysin (CHR) is a natural flavonoid with many properties such as antioxidant, anti-inflammatory and anti-apoptotic. The current study ...

Protective effects of sinapic acid against lead acetate-induced nephrotoxicity: a multi-biomarker approach

Şimşek, Hasan; Küçükler, Sefa; Gür, Cihan; Akaras, Nurhan; Kandemir, Fatih Mehmet (Springer Science and Business Media Deutschland GmbH, 2023)

Lead acetate (PbAc) is one of the top five most dangerous toxic heavy metals, particularly leading to kidney damage and posing serious health risks in both humans and animals. Sinapic acid (SNP) is a naturally occurring ...

Sıçan Dalak Dokusunda Akrilamidin İndüklediği Oksidatif Stres, İnflamasyona ve Apoptoza Karşı Morinin Koruyucu Etkileri: Biyokimyasal ve Histopatolojik Bir Yaklaşım

Akaras, Nurhan; Kandemir, Fatih Mehmet; Şimşek, Hasan; Küçükler, Sefa; Oğuz Kabayel, Rabia (Mustafa İSSİ, 2023)

Akrilamid (AKR), yaygın endüstri kullanımının yanı sıra yüksek karbonhidrat içerikli gıda maddelerinin ısı kaynaklı işlemleri (kavurma, fırınlama ve kızartma) sırasında oluşan sitotoksik ve kanserojen etkilere sahip kimyasal ...

Carvacrol Reduces Mercuric Chloride-Induced Testicular Toxicity by Regulating Oxidative Stress, Inflammation, Apoptosis, Autophagy, and Histopathological Changes

Şimşek, Hasan; Gür, Cihan; Küçükler, Sefa; İleritürk, Mustafa; Akaras, Nurhan; Öz, Mehmet; Kandemir, Fatih Mehmet (Springer, 2023)

Mercuric chloride (HgCl2) is a heavy metal that is toxic to the human body. Carvacrol (CAR) is a flavonoid found naturally in plants and has many biological and pharmacological activities including anti-inflammatory, ...