Browsing by Author "Genç, Aydın"
Now showing items 1-8 of 8
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Chrysin mitigates diclofenac-induced hepatotoxicity by modulating oxidative stress, apoptosis, autophagy and endoplasmic reticulum stress in rats
Varışlı, Behçet; Çağlayan, Cüneyt; Kandemir, Fatih Mehmet; Gür, Cihan; Ayna, Adnan; Ayna, Adnan; Genç, Aydın; Taysı, Seyithan (Springer Science and Business Media B.V., 2023)Diclofenac (DF) is a non-steroidal anti-inflammatory drug (NSAID) generally prescribed for the treatment of pain. In spite of the widespread use of DF, hepatotoxicity has been reported after its administration. The current ... -
Evaluation of the protective effects of morin against acrylamide-induced lung toxicity by biomarkers of oxidative stress, inflammation, apoptosis, and autophagy
Yeşildağ, Kerim; Eröz, Recep; Genç, Aydın; Doğan, Tuba; Satıcı, Emine (John Wiley and Sons Inc, 2022)Acrylamide (ACR) has genotoxic, neurotoxic, and carcinogenic effects. From past to present, various plants or their products have been used for therapeutic purposes such as morin. It was aimed to detect possible protective ... -
Hesperidin attenuates oxidative stress, inflammation, apoptosis, and cardiac dysfunction in sodium fluoride‐Induced cardiotoxicity in rats
Varışlı, Behçet; Darendelioğlu, Ekrem; Çağlayan, Cüneyt; Kandemir, Fatih Mehmet; Ayna, Adnan; Genç, Aydın; Kandemir, Özge (Springer, 2022)Excessive fluoride intake has been reported to cause toxicities to brain, thyroid, kidney, liver and testis tissues. Hesperidin (HSP) is an antioxidant that possesses anti-allergenic, anti-carcinogenic, anti-oxidant and ... -
Hesperidin has a protective effect on paclitaxel-induced testicular toxicity through regulating oxidative stress, apoptosis, inflammation and endoplasmic reticulum stress
İleritürk, Mustafa; Kandemir, Özge; Akaras, Nurhan; Şimsek, Hasan; Genç, Aydın; Kandemir, Fatih Mehmet (Elsevier Inc., 2023)Paclitaxel (PTX) is widely used to treat a number of malignancies, although it has toxic side effects. Hesperidin (HES) has a wide range of biological and pharmacological properties, including anti-inflammatory and antioxidant ... -
The impact of Nrf2/HO-1, caspase-3/Bax/Bcl2 and ATF6/IRE1/PERK/GRP78 signaling pathways in the ameliorative effects of morin against methotrexate-induced testicular toxicity in rats
Varışlı, Behçet; Çağlayan, Cüneyt; Kandemir, Fatih Mehmet; Gür, Cihan; Bayav, Ibrahim; Genç, Aydın (Springer, 2022)Background Methotrexate (MT) is a broadly used chemotherapeutic drug however its clinical use is confronted with several forms of toxicities containing testicular damage. The current study assessed the ameliorative effects ... -
Investigation of hemogram, oxidative stress, and some inflammatory marker levels in neonatal calves with escherichia coli and coronavirus diarrhea
Aydın, Ömer; Ulaş, Nergis; Genç, Aydın; Baysal, Sümeyye; Kandemir, Özge; Aktaş, Mustafa Sinan (Academic Press, 2022)Calf diarrhea is the most common disease affecting calves in the neonatal period resulting in economic losses. Although predisposing factors play a role in the etiology of the disease, in most cases, different pathogens ... -
Neuromodulatory effects of hesperidin against sodium fluoride-induced neurotoxicity in rats: Involvement of neuroinflammation, endoplasmic reticulum stress, apoptosis and autophagy
Yıldız, Mustafa Onur; Çelik, Hamit; Çağlayan, Cüneyt; Kandemir, Fatih Mehmet; Gür, Cihan; Bayav, İbrahim; Genç, Aydın; Kandemir, Özge (Neurotoxicology, 2022)Fluoride is an element with toxic properties and has been proven to have some adverse effects on many soft tissues, including brain tissue. This study aims to evaluate the protective effects of hesperidin on sodium fluoride ... -
Protective effect of naringin against oxaliplatin-induced peripheral neuropathy in rats: A behavioral and molecular study
Semis, Halil S.; Kandemir, Fatih M.; Çağlayan, Cüneyt; Kaynar, Özgür; Genç, Aydın; Arıkan, Şefik M. (Wiley, 2022)Oxaliplatin (OXL) is a chemotherapeutic drug used for metastatic and other types of cancer, but it causes peripheral neuropathy as a dose-limiting side effect. Herein, we used the rat model of OXL-induced peripheral ...
