Browsing by Author "Denkbaş, Emir Baki"
Now showing items 1-20 of 28
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Active nano/microbilayer hemostatic agents for diabetic rat bleeding model
Karahaliloğlu, Zeynep; Demirbilek, Murat; Ulusoy, İbrahim; Gümşkaya, Berrak; Denkbaş, Emir Baki (Wiley, 2017)Patients with diabetes mellitus have an increased cardiovascular risk due to the abnormality of hemostatic system components. Therefore, hemostasis is an important concept when considering that diabetics are under risk due ... -
Aligned bacterial PHBV nanofibrous conduit for peripheral nerve regeneration
Demirbilek, Murat; Sakar, Mustafa; Karahaliloğlu, Zeynep; Erdal, Ebru; Yalçın, Eda; Bozkurt, Gökhan; Korkusuz, Petek; Bilgiç, Elif; Temuçin, Çağri Mesut; Denkbaş, Emir Baki (Taylor & Francis Ltd, 2015)The conventional method of peripheral nerve gap treatment is autografting. This method is limited. In this study, an aligned nanofibrous graft was formed using microbial polyester, Poly (3-hydroxybutyrate-co-3-hydroxyvalerate) ... -
Antibacterial agent loaded fungal polymer for use as a wound dressing
Güven, Eylem; Şam, Mesut; Erdal, Ebru; Karahaliloğlu, Zeynep; Candan, Dilek; Sağlam, Necdet; Denkbaş, Emir Baki (Hacettepe Üniversitesi, 2011)This study is mainly concerned with the preparation and characterization of a novel wound dressing, in the form of three-dimensional micro-porous structure, from extracellular polysaccharide produced by Trametes Versicolor, ... -
Antibacterial chitosan/silk sericin 3D porous scaffolds as a wound dressing material
Karahaliloğlu, Zeynep; Kılıçay, Ebru; Denkbaş, Emir Baki (Taylor & Francis Ltd, 2017)Antimicrobial mixed dressings have traditionally been used to minimize bacterial infection of burns and other wounds. This study presents the advancement of biocompatible chitosan/silk sericin (CHT/SS) scaffolds combined ... -
Antisense oligonucleotide delivery to cancer cell lines for the treatment of different cancer types
Kılıçay, Ebru; Erdal, Ebru; Hazer, Baki; Türk, Mustafa; Denkbaş, Emir Baki (Taylor & Francis Ltd, 2016)Amphiphilic poly(3-hydroxylalkanoate) (PHA) copolymers find interesting applications in drug delivery. The aim of this study was to prepare nucleic acid adsorbed on (PHB-b-PEG-NH2) nanoparticle platform for gene delivery. ... -
A comparative study of receptor-targeted magnetosome and HSA-coated iron oxide nanoparticles as MRI contrast-enhancing agent in animal cancer model
Erdal, Ebru; Demirbilek, Murat; Yeh, Yasan; Akbal, Öznur; Ruff, Laura; Bozkurt, Damla; Çabuk, Ahmet; Senel, Yasin; Gümüşkaya, Berrak; Algın, Oktay; Çolak, Şeyda; Esener, Sadık; Denkbaş, Emir Baki (Humana Press, 2018)Magnetosomes are specialized organelles arranged in intracellular chains in magnetotactic bacteria. The superparamagnetic property of these magnetite crystals provides potential applications as contrast-enhancing agents ... -
Comparison of protein- and polysaccharide-based nanoparticles for cancer therapy: synthesis, characterization, drug release, and interaction with a breast cancer cell line
Akbal, Öznur; Erdal, Ebru; Vural, Tayfun; Kavaz, Doǧa; Denkbaş, Emir Baki (Taylor & Francis, 2017)In this study, human serum albumin (HSA) was used as a protein-based material and poly (3-hydroxybutyrate) (PHB)-carboxymethyl chitosan (CMCh) as a polysaccharide-based material for the production of nanoparticles to be ... -
Concanavaline A conjugated bacterial polyester-based PHBHHx nanoparticles loaded with curcumin for breast cancer therapy
Kılıçay, Ebru; Karahaliloğlu, Zeynep; Hazer, Baki; Tekin, İshak Özel; Denkbaş, Emir Baki (Taylor & Francis, 2016)The aim of this study was to evaluate therapeutic potential of curcumin-loaded poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) PHBHHx nanoparticles (CUR-NPs) and concanavaline A conjugated curcumin-loaded NPs (ConA-CUR-NPs) ... -
Development of electrochemical biosensor platforms for determination of environmental viral structures
Ekici, Rümeysa; Bozdoğan, Betül; Denkbaş, Emir Baki (MDPI, 2022)Infectious diseases caused by viruses (such as influenza, Zika, human immunodeficiency, Ebola, dengue, hepatitis, and COVID-19 virus) are diseases that have been on the agenda of the whole world for the last quarter of a ... -
Enhanced antitumor activity of epigallocatechin gallate-conjugated dual-drug-loaded polystyrene-polysoyaoil-diethanol amine nanoparticles for breast cancer therapy
Karahaliloğlu, Zeynep; Kılıçay, Ebru; Alpaslan, Pınar; Hazer, Baki; Denkbaş, Emir Baki (Sage Publications Ltd, 2018)The development of novel combination anticancer drug delivery systems is an important step to improve the effectiveness of anticancer treatment in metastatic breast cancer and to overcome increased toxicity of the currently ... -
Hemostatic activities of nano/microporous bilayer dressings in a femoral artery bleeding rat model
Karahaliloğu, Zeynep; Demirbilek, Murat; Ulusoy, İbrahim; Gümüşkaya, Berrak; Denkbaş, Emir Baki (Wiley-Blackwell, 2016)Recently, an effective hemostatic dressing requirement has become a major problem in both the military and civilian world. Available hemostatic agents are too expensive, ineffective, unsafe, or complicated to use. Here, ... -
In vitro biocompatibility of plasma-aided surface-modified 316L stainless steel for intracoronary stents
Bayram, Cem; Mızrak, Alpay Koray; Aktürk, Selçuk; Kurşaklıoğlu, Hürkan; İyisoy, Atila; İfran, Ahmet; Denkbaş, Emir Baki (IOP Publishing LTD, 2010)316L-type stainless steel is a raw material mostly used for manufacturing metallic coronary stents. The purpose of this study was to examine the chemical, wettability, cytotoxic and haemocompatibility properties of 316L ... -
In vitro evaluation of antisense oligonucleotide functionalized core-shell nanoparticles loaded with -tocopherol succinate
Kılıçay, Ebru; Karahalıloğlu, Zeynep; Alpaslan, Pınar; Hazer, Baki; Denkbaş, Emir Baki (Taylor & Francis, 2017)Antisense oligonucleotide (ASO)-conjugated--tocopherol succinate (TCS)-loaded-poly(lactic acid)-g-poly(ethylene glycol) nanoparticles (ASO-TCS-PLA-PEG NPs), with the ratio of polymer/TCS of 10:2.5, 10:5, 10:7 (w/w) were ... -
Magnetic silk fibroin e-gel scaffolds for bone tissue engineering applications
Karahaliloğlu, Zeynep; Yalçın, Eda; Demirbilek, Murat; Denkbaş, Emir Baki (SAGE PUBLICATIONS, 2017)Recently, the incorporation of magnetic nanoparticles into standard scaffolds has emerged as a promising approach for tissue engineering applications. This strategy can promote not only tissue regeneration but also reloading ... -
Osteoblast activity on anodized titania nanotubes: Effect of simulated body fluid soaking time
Bayram, Cem; Demirbilek, Murat; Çalışkan, Nazlı; Demirbilek, Melike Erol; Denkbaş, Emir Baki (American Scientific Publishers, 2012)Early phase osseointegration is crucial for orthopedic implants. For the improvement of osseointegrative properties of orthopedic implants several surface modification methods such as acid etching, hydroxyapatite (HA) ... -
Osteoblast response on co-modified titanium surfaces via anodization and electrospinning
Bayram, Cem; Demirbilek, Murat; Yalçın, Eda; Bozkurt, Murat; Doğan, Metin; Denkbaş, Emir Baki (ELSEVIER SCIENCE BV, 2014)Topography plays a key role in osseointegration and surface modifications at the subcellular level, increasing initial cell attachment in the early period. In the past decade, nanosized texture on metal like a nanotube ... -
Oxidative stress parameters of L929 cells cultured on plasma-modified PDLLA scaffolds
Demirbilek, Melike Erol; Demirbilek, Murat; Karahaliloğlu, Zeynep; Erdal, Ebru; Vural, Tayfun; Yalçın, Eda; Sağlam, Necdet; Denkbaş, Emir Baki (Humana Press, 2011)Oxidative stress may produce high level of reactive oxygen species (ROS) following cell exposure to endogenous and exogenous factors. Recent experiments implicate oxidative stress as playing an essential role in cytotoxicity ... -
Plasma polymerization-modified bacterial polyhydroxybutyrate nanofibrillar scaffolds
Karahaliloğlu, Zeynep; Demirbilek, Murat; Şam, Mesut; Erol-Demirbilek, Melike; Sağlam, Necdet; Denkbaş, Emir Baki (Wiley-Blackwell, 2013)The design and the development of novel scaffold materials for tissue engineering have attracted much interest in recent years. Especially, the prepared nanofibrillar scaffold materials from biocompatible and biodegradable ... -
Porous polyurethane film fabricated via the breath figure approach for sustained drug release
Daban, Gizem; Bayram, Cem; Bozdoğan, Betül; Denkbaş, Emir Baki (Wiley, 2019)The breath figure (BF) method is an effective process for fabricating porous polymeric films. In this study, we fabricated porous polymer films from thermoplastic polyurethane (PU) through static BF with CHCl3 as a solvent ...
