Browsing by Author "Akarsu, Serkan Ali"
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Ameliorative effects of sinapic acid against vancomycin-induced testicular oxidative damage, apoptosis, inflammation, testicular histopathologic disorders and decreased epididymal sperm quality
Akarsu, Serkan Ali; İleritürk, Mustafa; Küçükler, Sefa; Akaras, Nurhan; Gür, Cihan; Kandemir, Fatih Mehmet (Elsevier, 2024)In this study, it was aimed to determine the effect of sinapic acid (SNP), a polyphenol with antioxidant, anti-inflammatory and antibacterial properties, on testicular damage caused by vancomycin (VCM), a widely used ... -
Carvacrol reduces abnormal and dead sperm counts by attenuating sodium arsenite-induced oxidative stress, inflammation, apoptosis, and autophagy in the testicular tissues of rats
Gür, Cihan; Akarsu, Serkan Ali; Akaras, Nurhan; Tuncer, Sibel Çiğdem (Wiley, 2023)Arsenic (As) is a highly toxic metalloid. Carvacrol (CAR) is the active ingredient of Lamiaceae plants and has various biological and pharmacological properties. The present study investigated the protective effects of ... -
Effect of syringic acid on oxidative stress, autophagy, apoptosis, inflammation pathways against testicular damage induced by lead acetate.
Akarsu, Serkan Ali; Gür, Cihan; İleritürk, Mustafa; Akaras, Nurhan; Küçükler, Sefa; Kandemir, Fatih Mehmet (Elsevier GmbH, 2023)Heavy metals are one of the environmental pollutants. Lead (Pb) is one of the most common of these heavy metals. In this study, it was aimed at investigating the effects of syringic acid (SA) against testicular toxicity ... -
Effects of sinapic acid on lead acetate-induced oxidative stress, apoptosis and inflammation in testicular tissue
Tuncer, Sibel Çiğdem; Akarsu, Serkan Ali; Küçükler, Sefa; Gür, Cihan; Kandemir, Fatih Mehmet (John Wiley and Sons Inc, 2023)In this study, the effect of lead acetate (PbAc) and sinapic acid (SNP) administration on oxidative stress, apoptosis, inflammation, sperm quality and histopathology in testicular tissue of rats was tried to be determined. ... -
Effects of zingerone on rat induced testicular toxicity by sodium arsenite via oxidative stress, endoplasmic reticulum stress, inflammation, apoptosis, and autophagy pathways
Tuncer, Sibel Çiǧdem; Gür, Cihan; Küçükler, Sefa; Akarsu, Serkan Ali; Kandemir, Fatih Mehmet (Mashhad University of Medical Sciences, 2024)This study aimed to investigate the effects of zingerone (ZNG) treatment on testicular toxicity in rats induced by sodium arsenite (SA). Materials and Methods: In the study, five groups were formed (n=7) and the experimental ... -
Investigation of the Effects of Rutin on Valproic Acid Induced Testicular Damage in Rats
Akarsu, Serkan Ali; Kankılıç, Nazım Abdülkadir; Erdoğan, Ender (Afyon Kocatepe Üniversitesi, 2023)Valproic acid (VALP) is a drug used for many psychiatric diseases such as epilepsy. However, the use of VALP has potential side effects on various tissues, including the testicles. Rutin (RUT) is a flavonoid with protective ... -
Naringin protects against paclitaxel-induced toxicity in rat testicular tissues by regulating genes in pro-inflammatory cytokines, oxidative stress, apoptosis, and JNK/MAPK signaling pathways
Kankılıç, Nazım Abdülkadir; Küçükler, Sefa; Gür, Cihan; Akarsu, Serkan Ali; Akaras, Nurhan; Şimşek, Hasan; İleritürk, Mustafa; Kandemir, Fatih Mehmet (John Wiley and Sons Inc, 2024)Paclitaxel (PTX), which is actively used in the treatment of many types of cancer, has a toxic effect by causing increased oxidative stress in testicular tissues. Naringin (NRG) is a natural flavonoid found in plants, and ... -
Protective effects of syringic acid against oxidative damage, apoptosis, autophagy, inflammation, testicular histopathologic disorders, and impaired sperm quality in the testicular tissue of rats induced by mercuric chloride
Akarsu, Serkan Ali; Gür, Cihan; Küçükler, Sefa; Akaras, Nurhan; İleritürk, Mustafa; Kandemir, Fatih Mehmet (John Wiley and Sons Inc, 2024)Mercury (Hg) is one of the most toxic heavy metals that damage testicular tissue. Mercury chloride (HgCl2) is one of the most toxic forms of mercury that can easily cross biological membranes. Syringic acid (SA) is a natural ...