Browsing by Author "Şimşek, Hasan"
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Abamektin kaynaklı mide toksisitesinde hesperidinin oksidatif stres, inflamasyon ve apoptoz üzerindeki koruyucu etkisi
Tuncer, Sibel Çiğdem; Gür, Cihan; Şimşek, Hasan; Kandemir, Fatih Mehmet (Ayşe SURUÇ, 2024)Abamektin günümüzde tarım endüstrisinde çok fazla kullanılan bir pestisit türü olup uzun süreli maruziyet sonucunda toksik etkilere sahiptir. Uzun süreli abamektin maruziyeti sonucunda özellikle oksidatif stres ilişkili ... -
Acacetin ameliorates acetylsalicylic acid-induced gastric ulcer in rats by interfering with oxidative stress, inflammation, and apoptosis
Şimşek, Hasan; Akaras, Nurhan (Ali Cangül, 2023)Gastric ulcer (GU) is a benign lesion in which excessive acid and pepsin activity affects the mucosal ep- ithelium and is common worldwide. Gastrointestinal disturbances come to the fore among the side effects observed in ... -
The ameliorative effect of carvacrol on sodium arsenite-induced hepatotoxicity in rats: Possible role of Nrf2/HO-1, RAGE/NLRP3, Bax/Bcl-2/Caspase-3, and Beclin-1 pathways
Gencer, Selman; Gür, Cihan; İleritürk, Mustafa; Küçükler, Sefa; Akaras, Nurhan; Şimşek, Hasan; Kandemir, Fatih M. (John Wiley and Sons Inc, 2024)Arsenic is a toxic environmental pollutant heavy metal, and one of its critical target tissues in the body is the liver. Carvacrol is a natural phytocompound that stands out with its antioxidant, anti-inflammatory, and ... -
The ameliorative effects of chrysin on bortezomib-induced nephrotoxicity in rats: Reduces oxidative stress, endoplasmic reticulum stress, inflammation damage, apoptotic and autophagic death
Kankılıç, Nazım Abdülkadir; Şimşek, Hasan; Akaras, Nurhan; Gür, Cihan; Küçükler, Sefa; Gencer, Selman; Kandemir, Fatih Mehmet (Elsevier Ltd, 2024)Bortezomib is a proteasome inhibitor antineoplastic agent that was the first to be approved for cancer treatment. One of bortezomib's most prominent dose-limiting effects is nephrotoxicity; the underlying mechanism is ... -
Anti-oxidant, Anti-inflammatory, and Anti-apoptotic Effects of Rutin in Spleen Toxicity Induced by Sodium Valproate in Rats
Akaras, Nurhan; Kandemir, Fatih Mehmet; Şimşek, Hasan; Gür, Cihan; Aygörmez, Serpil (Bingöl Üniversitesi Fen Bilimleri Enstitüsü, 2023)Long-term exposure to sodium valproate, an anti-epileptic drug, causes toxic effects in tissues, especially by increasing oxidative stress and inflammation. Rutin is a flavanoid with anti- oxidant, anti-inflammatory and ... -
The antinociceptive effect of Adalimumab, a TNF-Alpha Inhibitor, in a Mice model of inflammatory pain
Öz, Mehmet; Şimşek, Hasan (2022)The aim of this study, evaluate the nociceptive effect of adalimumab, a TNF-alpha inhibitor, on formalin-induced inflammatory pain in mice. The antinociceptive activity of adalimumab was determined on adult male BALB-C ... -
Beneficial effects of Chrysin on Cadmium-induced nephrotoxicity in rats: Modulating the levels of Nrf2/HO-1, RAGE/NLRP3, and Caspase-3/Bax/Bcl-2 signaling pathways
Şimşek, Hasan; Akaras, Nurhan; Gür, Cihan; Küçükler, Sefa; Kandemir, Fatih Mehmet (Elsevier B.V., 2023)Cadmium (Cd) is a toxic heavy metal that targets the kidney directly in the body. Chrysin (CHR) is a natural flavonoid with many properties such as antioxidant, anti-inflammatory and anti-apoptotic. The current study ... -
Carvacrol Reduces Mercuric Chloride-Induced Testicular Toxicity by Regulating Oxidative Stress, Inflammation, Apoptosis, Autophagy, and Histopathological Changes
Şimşek, Hasan; Gür, Cihan; Küçükler, Sefa; İleritürk, Mustafa; Akaras, Nurhan; Öz, Mehmet; Kandemir, Fatih Mehmet (Springer, 2024)Mercuric chloride (HgCl2) is a heavy metal that is toxic to the human body. Carvacrol (CAR) is a flavonoid found naturally in plants and has many biological and pharmacological activities including anti-inflammatory, ... -
The Effect of High Salt Diet on Anxiety-Depression-Like Behaviors and Cognitive Function in Female and Male Mice
Şimşek, Hasan; Öz, Mehmet (Wiley, 2023)The Effect of High Salt Diet on Anxiety-Depression-Like Behaviors and Cognitive Function in Female and Male Mice... -
The Effect of Smartphone Addiction on Attention Level in High School Students
Şimşek, Hasan (Galenos Yayınevi, 2023)Smartphones are electronic devices that have an important place in our lives today and provide many conveniences. However, it can cause many problems such as distraction and social isolation. The aim of this study is to ... -
Effects of Quercetin on Cypermethrin-Induced Stomach Injury: The Role of Oxidative Stress, Inflammation, and Apoptosis
Akaras, Nurhan; Gür, Cihan; Şimşek, Hasan; Tuncer, Sibel Çiğdem (Gümüşhane Üniversitesi, 2023)This study was conducted to investigate the effects of quercetin (QUE) on cypermethrin (CYP) induced gastrotoxicity in rats. 35 Sprague-Dawley rats were randomly divided into five groups, 7 in each group. In the study, 25 ... -
A histological and biochemical study of the protective role of hesperidin in testicular ischemia-reperfusion injury
Akaras, Nurhan; Şimşek, Hasan; Ordu, Melike (Ali Cangül, 2023)This study aimed to investigate the possible effects of hesperidin on ischemia-reperfusion (IR) injury applied to rat testis. Methods: Twenty-eight Wistar albino rats were used and divided into four groups of seven each. ... -
Naringin attenuates oxaliplatin-induced nephrotoxicity and hepatotoxicity: A molecular, biochemical, and histopathological approach in a rat model
İleritürk, Mustafa; Kandemir, Özge; İleritürk, Duygu; Akaras, Nurhan; Şimşek, Hasan; Erdoğan, Ender; Kandemir, Fatih M. (Wiley, 2024)Oxaliplatin (OXL) is a significant therapy agent for the worldwide increase in cancer cases. Naringin (4′,5,7‐trihydroxy flavonon 7‐rhamnoglucoside, NRG) has a wide range of biological and pharmacological activities, ... -
Naringin protects against paclitaxel-induced toxicity in rat testicular tissues by regulating genes in pro-inflammatory cytokines, oxidative stress, apoptosis, and JNK/MAPK signaling pathways
Kankılıç, Nazım Abdülkadir; Küçükler, Sefa; Gür, Cihan; Akarsu, Serkan Ali; Akaras, Nurhan; Şimşek, Hasan; İleritürk, Mustafa; Kandemir, Fatih Mehmet (John Wiley and Sons Inc, 2024)Paclitaxel (PTX), which is actively used in the treatment of many types of cancer, has a toxic effect by causing increased oxidative stress in testicular tissues. Naringin (NRG) is a natural flavonoid found in plants, and ... -
Protective effects of naringin on colistin-induced damage in rat testicular tissue: Modulating the levels of Nrf-2/HO-1, AKT-2/FOXO1A, Bax/Bcl2/Caspase-3, and Beclin-1/LC3A/LC3B signaling pathways
Kankılıç, Nazım Abdülkadir; Şimşek, Hasan; Akaras, Nurhan; Gür, Cihan; İleritürk, Mustafa; Küçükler, Sefa; Akarsu, Serkan A.; Kandemir, Fatih M. (John Wiley and Sons Inc, 2024)Antimicrobial agent resistance has become a growing health issue across the world. Colistin (COL) is one of the drugs used in the treatment of multidrug-resistant bacteria resulting in toxic effects. Naringin (NRG), a ... -
Protective effects of sinapic acid against lead acetate-induced nephrotoxicity: a multi-biomarker approach
Şimşek, Hasan; Küçükler, Sefa; Gür, Cihan; Akaras, Nurhan; Kandemir, Fatih Mehmet (Springer Science and Business Media Deutschland GmbH, 2023)Lead acetate (PbAc) is one of the top five most dangerous toxic heavy metals, particularly leading to kidney damage and posing serious health risks in both humans and animals. Sinapic acid (SNP) is a naturally occurring ... -
Protective effects of zingerone against sodium arsenite-induced lung toxicity: A multi-biomarker approach
Şimşek, Hasan; Küçükler, Sefa; Gür, Cihan; İleritürk, Mustafa; Aygörmez, Serpil; Kandemir, Fatih Mehmet (Mashhad University of Medical Sciences, 2023)Sodium arsenite (SA) exposure is toxic to the body. Zingerone (ZNG) is a flavonoid with many biological properties found naturally in honey and plants. This study aimed to determine the effects of ZNG on SA-induced rat ... -
Sıçan Dalak Dokusunda Akrilamidin İndüklediği Oksidatif Stres, İnflamasyona ve Apoptoza Karşı Morinin Koruyucu Etkileri: Biyokimyasal ve Histopatolojik Bir Yaklaşım
Akaras, Nurhan; Kandemir, Fatih Mehmet; Şimşek, Hasan; Küçükler, Sefa; Oğuz Kabayel, Rabia (Mustafa İSSİ, 2023)Akrilamid (AKR), yaygın endüstri kullanımının yanı sıra yüksek karbonhidrat içerikli gıda maddelerinin ısı kaynaklı işlemleri (kavurma, fırınlama ve kızartma) sırasında oluşan sitotoksik ve kanserojen etkilere sahip kimyasal ... -
Sıçanlarda İfosfamid ile Oluşturulmuş Mide Hasarında Morinin Etkilerinin Histopatolojik ve Biyokimyasal Olarak İncelenmesi
Akaras, Nurhan; İleritürk, Mustafa; Kandemir, Fatih Mehmet; Şimşek, Hasan; Aygörmez, Serpil (Mustafa İSSİ, 2023)Bu çalışmada, sıçanlarda deneysel ifosfamid (IFO) uygulamasının neden olduğu mide toksisitesi üzerine morinin (MOR) etkilerinin belirlenmesi amaçlandı. Bu amaçla deney hayvanları beş gruba (n=7) ayrıldı. Gruplar kontrol, ...
