Browsing by Author "Özdemir, Selçuk"

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Beneficial effects of quercetin on vincristine-induced liver injury in rats: Modulating the levels of Nrf2/HO-1, NF-kB/STAT3, and SIRT1/PGC-1α

Çomaklı, Selim; Özdemir, Selçuk; Küçükler, Sefa; Kandemir, Fatih Mehmet (Wiley, 2023)

Our experimental objective was to investigate the hepatotoxic effect of vincristine (VCR) administration in rats and determined whether combined therapy with Quercetin (Quer) ensured protection. Five groups with seven rats ...
Hesperidin counteracts chlorpyrifos-induced neurotoxicity by regulating oxidative stress, inflammation, and apoptosis in rats

Küçükler, Sefa; Çağlayan, Cüneyt; Özdemir, Selçuk; Çomaklı, Selim; Kandemir, Fatih Mehmet (Springer, 2024)

Chlorpyrifos (CPF), considered one of the most potent organophosphates, causes a variety of human disorders including neurotoxicity. The current study was designed to evaluate the efficacy of hesperidin (HSP) in ameliorating ...
Investigation of the effects of berberine on bortezomib-induced sciatic nerve and spinal cord damage in rats through pathways involved in oxidative stress and neuro-inflammation

Yardım, Ahmet; Gür, Cihan; Çomaklı, Selim; Özdemir, Selçuk; Küçükler, Sefa; Çelik, Hamit; Kandemir, Fatih Mehmet (Elsevier B.V., 2022)

Bortezomib (BTZ), a proteasome inhibitor, causes dose-limiting peripheral neuropathy in humans. Berberine (BBR), which has various biological and pharmacological properties, is known to have neuroprotective properties. The ...