Aksaray Üniversitesi Kurumsal Akademik Arşivi
DSpace@Aksaray, Aksaray Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Prediction of cutting parameters and reduction of output parameters using machine learning in milling of Inconel 718 alloy
(Nature Research, 2025) Hamıd, Maher Waleed Hamıd; Özlü, Barış; Ulaş, Hasan Basri; Demir, Halil
The present study focuses on the effects of cooling/lubrication conditions and cutting parameters on energy consumption (EC), carbon emissions (CE), surface roughness (Ra), cutting temperature (T), tool wear (Vb) and vibration (Vib) in sustainable milling of Inconel 718 alloy. Also, it was aimed to estimate the EC, CE, Ra, T and Vib values obtained in milling experiments using three different regression-based machine learning (ML) models. The performances of the models used in ML were compared using R-squared, MSE and MAPE performance criteria. In the experiments conducted by reducing the feed rate and cutting speed and in MQL machining conditions, it was observed that EC and CE values reached minimum values. In MQL machining conditions, it was observed that the lowest Ra values were achieved at high cutting speed and low feed rate. The lowest Vb was measured at low cutting speed and feed rate in air machining conditions. Increasing the cutting speed and decreasing the feed rate in MQL machining conditions had a positive effect on Vib. In the MQL machining condition, at 40 m/min cutting speed and 0.06 mm/rev feed rate, the lowest energy consumption and carbon emission were 0.76 kJ/s and 0.54796 kg-CO2 respectively. The lowest surface roughness and vibration values were measured as 0.234 μm and 1.91 mm/s respectively, at 80 m/min cutting speed and 0.06 mm/rev feed rate in MQL machining condition. The lowest cutting temperature was measured as 31 °C at a cutting speed of 40 m/min and a feed rate of 0.06 mm/rev under air machining conditions. It was seen that the EC, CE, Ra, T and Vib values arising from the input parameters in the machining of Inconel 718 alloy could be successfully predicted using three different regression-based ML models.
Bringing exosomes into the game: Current situation, opportunities, limitations and future perspectives
(Elsevier Ltd, 2025) Dikici, Emrah; Önal Acet, Burcu; Gül, Désirée; Kummer, Nina; Stauber, Roland H.; Odabaşı, Mehmet; Acet, Ömür
Exosomes are microscopic vesicles secreted by cells, serving as carriers of diverse biological substances and playing an essential role in the communication between cells. When meticulously engineered, these small extracellular vesicles transform into highly effective delivery systems for therapeutic agents, enabling the targeted administration of active pharmaceutical ingredients to specific organs, tissues, and cells. Exosomes play an indispensable role in a myriad of biological processes, including intercellular communication, the regulation of gene expression, apoptosis, inflammation, immunity, as well as cell maturation and differentiation. The versatile role of exosomes is largely attributed to their intricate cargoes and composition, which encompasses nucleic acids, proteins, and lipids. In this review, we present a comprehensive overview of state-of-the-art characterization and isolation techniques used for the study of exosomes, especially for exosome-based biomedical applications. We will discuss the potential use of exosomes in personalized treatments, their interactions with other nanostructures focusing on the biomolecule corona, as well as the challenges and future expectations. In conclusion, this review provides evidence that we will witness extremely important functions and advances with innovative therapeutic and diagnostic applications of exosomes in the biomedical field.
Molecular characterization and phylogenetic analysis of Pulex irritans (Siphonaptera: Pulicidae) fleas collected from sheep in Sivas Province, Türkiye
(Elsevier B.V., 2025) Önder, Zuhal; Arslanhan, Batuhan Aşkım; Çifci, Sümmani
Flea infestation in sheep is a significant public health concern due to their widespread distribution worldwide and the transmission of flea-borne diseases. In this study, we aimed to identify and molecularly characterize P. irritans collected from sheep, using morphological, molecular, and phylogenetic analysis. Flea samples were collected from sheep on six farms in Sivas Province, Türkiye, between April and September 2024. The flea specimens were morphologically identified using identification keys. After total genomic DNA extraction and Polymerase Chain Reactions (PCR), the PCR products were sent for sequencing. This morphological study indicated that from the 250 adult fleas collected from sheep, 223 specimens (110 female and 113 male) belonged to the human flea, Pulex irritans. Also, mt-COI gene region Blast analysis results confirmed that all samples were P. irritans. Additionally, molecular analysis revealed a high sequence similarity (99.8 %) with P. irritans isolates from Iran and Australia, which are available in GenBank. Considering the relatively high frequency of presence of this ectoparasite in the sheep, further studies focused on the possibility of being a vector of pathogens and their distribution between these animals and humans are recommended. The results of this study can be used to identify flea-borne disease risks and develop effective control measures.
Comprehensive assessment of heavy metal contamination in forested and agricultural soils: Distribution patterns, source apportionment, environmental and human health risks
(Elsevier B.V., 2025) Demirela, Gökhan; Terzi, Mustafa Haydar; Durgun, Mehmet Barış
Soil contamination by heavy metals (HMs) is a growing concern in Sakarya Province, where migration and land-use changes increasingly threaten forested and agricultural areas. To overcome to limitations of conventional surface-only studies, this study introduces a novel dual sampling strategy that integrates 1317 surface soil and 745 drill core samples, to assess HM contamination and associated ecological and human health risks in the Kamışlı (Geyve) region, an important agricultural zone in northwestern Türkiye. This combined approach allows a more accurate distinction between geogenic versus anthropogenic sources, improving source apportionment and pollution characterization. Maximum HMs concentrations in the soils reached 70 ppm (As), 56 ppm (Co), 175 ppm (Cu), 896 ppm (Ni), 41 ppm (Pb), and 156 ppm (Zn). Some soils exceeded not only local rock concentrations but also geological reference values. Litho-geochemical correlations between soils and rocks highlight geogenic contributions, while multivariate statistics reveal overlapping anthropogenic influences. Geoaccumulation and pollution load indexes indicate variable contamination levels, and ecological risk assessment emphasizes Ni and As as the most critical pollutants. Human health risk analysis shows that both adults and children may face carcinogenic and non-carcinogenic risks primarily from Ni, while As and Pb pose tolerable and low cancer risks. By integrating geological and environmental data, our sampling framework provides clearer evidence of contamination pathways, improves the accuracy of source apportionment, and suggests a stronger basis for sustainable land-use planning. Effective control requires identifying pollution sources and integrating soil contamination assessments into early-stage environmental planning, especially in rapidly transforming rural areas.
Achieving accessibility on a budget: Aksaray University's strategy for supporting students with disabilities
(Springer, 2024) İşlek, Önder; Uyanık, Hatice
Much emphasis has been put on the inclusivity of educational opportunities in international agreements, conventions, and declarations, with the valuable work that continues to be done globally. However, one area needs more attention for disability-inclusive international development, that is, higher education, which is still limited and not fully inclusive or accessible for individuals with disabilities globally (Covas & de Luna, 2019). This chapter presents a case study of the Aksaray University in the Republic of Türkiye. This chapter aims to deconstruct the Turkish social system with emphasis on education and employment first and show an example of how the current system is disrupted to ensure the proper application of international agendas that Türkiye is officially and legally a part of. For this chapter an eclectic approach is used combining a wicked problem frame with disability studies in education from a reconceptualist perspective. This chapter is arranged into four sections, including (a) background on education and employment in the Turkish legal and social system to understand the foundation of current systems that is a gateway or product of higher education for individuals with disabilities; (b) recent understanding of the inclusive, accessible, and nondiscriminatory higher education and where the Turkish higher education system stands in it for individuals with disabilities; (c) a case example of Aksaray University for how to disrupt the system by provision of the disability support services within the university; and (d) conclusion with future implications for policy, research, and practice.
