Aksaray Üniversitesi Kurumsal Akademik Arşivi
DSpace@Aksaray, Aksaray Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Some predictive ındexes are potentially promising clinical parameters in dogs with primary cholangitis-cholangiohepatitis
(Wiley-Blackwell Publishing Ltd, 2025) Çolakoğlu, Ekrem Çağatay; Aydemir, Melek; Sevim, Kadir; Haydardedeoğlu, Ali Evren; Kaya, Ufuk
The invasive nature of liver biopsy and the risk of complications make patients reluctant to undergo the procedure. This situation has necessitated the search for easily accessible haematological indexes such as neutrophil-to-lymphocyte ratio (NLR) and red cell distribution width to lymphocyte ratio (RDW/LYM) to contribute to the clinical diagnosis and prognosis evaluation processes in dogs with cholangitis-cholangiohepatitis. Objectives: The aim of the study is to evaluate some predictive markers to contribute the clinical diagnosis in dogs with cholangitis-cholangiohepatitis. Medhods: Seventeen client-owned dogs with cholangitis-cholangiohepatitis were randomly allocated. Nine clinically healthy dogs (control group) confirmed with clinical examination, complete blood count (CBC) and serum profiles were used. Cholangitis-cholangiohepatitis was diagnosed in dogs with dilated bile ducts, thickened gallbladder wall up to 4 mm and increased parenchymal echogenicity. Clinical procedures including clinical examination, blood analyses and diagnostic abdominal ultrasonography were performed in all dogs. CBC indices such as NLR, mean platelet volume to platelet ratio (MPV/PLT), red cell distribution width to platelet ratio (RDW/PLT), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR) and RDW/LYM were calculated using absolute CBC values. Results: A final total of 10 dogs were enrolled in the study. NLR and RDW/LYM ratios were significantly higher (p < 00.5) in dogs with cholangitis-cholangiohepatitis compared to healthy ones. Conclusion: The results of this study suggest that the use of NLR and RDW/LYM ratio in dogs with cholangitis-cholangiohepatitis complex appears potentially promising. Larger prospective, case-control studies are needed to further evaluate these findings. Veterinary practitioners can obtain valuable diagnostic data before possible invasive liver procedures by evaluating NLR and RDW/LYM ratios, which are easily obtained from CBC parameters.
Validation of Turkish psoriatic arthritis screening tool for psoriatic arthritis: A cross-sectional comparative study
(Lippincott Williams and Wilkins, 2025) Başar Kılıç, Şeyma; Kulu, Huzeyfe; Salman, Hüseyin; Bektaş, Murat
Psoriasis (PsO) is a chronic immune-mediated disease that affects the skin and nails. Several screening tools such as psoriasis epidemiology screening tool, psoriatic arthritis screening and evaluation, early arthritis for psoriatic patients (EARP), STRIPP, SIPAS, and TOPAS have been developed and validated for identifying patients with suspected psoriatic arthritis (PsA) in dermatology clinics. Herein, we aim to validate and evaluate the performance of TurPAS in patients with PsO compared to the EARP questionnaire. This cross-sectional study was carried out in collaboration between dermatology and rheumatology clinics at Aksaray University Hospital, a tertiary referral center. All patients were examined for dermatologic aspects in the dermatology outpatient clinic and TurPAS and EARP questionnaires were performed by the same dermatologist. The patients who met the CASPAR criteria were classified as PsA in addition to appropriate clinical findings. In our study, 119 patients (n=72; 60.5% female) with PsO were included. Mean±standard deviation age of the patients was 44.9±14.3 (range; 18-83) years and the median (IQR) PsO duration was 10 (14) years. Median (IQR) TurPAS and EARP scores were 2 (3) and 3 (5), respectively. Overall, 39 patients (32.8%) met the CASPAR criteria and were classified as PsA. The best diagnostic accuracy was observed in≥3 positive items with 82% and 70% sensitivity and specificity (positive predictive value: 57.1%, negative predictive value: 89%, likelihood ratio: 2.7, diagnostic accuracy: 74%) for TurPAS and≥4 items with 74.4% and 86.3% (positive predictive value: 72.5%, negative predictive value: 87.3%, likelihood ratio: 5.4, diagnostic accuracy: 82.4%) for EARP. In our study, approximately one-third of patients with PsO were diagnosed as PsA. TurPAS had acceptable diagnostic performance compared to the EARP questionnaire. © 2025 the Author(s).
A different perspective solitons on sasakian manifolds admitting general connection
(Univerzita Komenskeho, 2025) Mert, T.; Atçeken, Mehmet; Siddiqi M.D.
In this study, we investigate the geometry of Sasakian manifolds that admit a general connection by means of special curvature conditions. We combine η-Ricci-Yamabe solitons with some special curvature conditions such as the projective and W1-curvature tensors, and obtain important characterizations of the Sasakian manifold. Furthermore, we present important results for Sasakian manifolds concerning different connections such as Tanaka-Webster, Schouten-Van Kampen, and Zamkovoy. © 2025, Comenius University in Bratislava. All rights reserved.
In-situ formation of ZnO nanorods on bacterial cellulose nanofibers for antibacterial efficacy
(Wiley-Blackwell Publishing Ltd, 2025) Topçu, Aykut Arif; İnal, Murat; Bakhshpour-Yücel, Monireh; Sağlam, Necdet; Denizli, Adil
In this work, affordable and biopolymer-based antibacterial material was fabricated through in-situ formation of ZnO nanorods. For that purpose, bacterial cellulose nanofibers (BCNFs) were obtained with the cultivation of Acetobacter xylinum, following that ZnO nanorods were in-situ formed in a single dimension on BCNFs using hexamethylenetetramine, a chelating agent. Before the antibacterial efficacy of antibacterial material toward gram-positive and gram-negative bacterial species, Fourier transform infrared spectroscopy (FTIR), scanning electron microscope (SEM), energy dispersive x-ray (EDX), x-ray diffraction (XRD) analysis were applied and swelling studies, and atomic absorption spectrometry (AAS) measurements were done for characterization studies. As demonstrated in SEM images and XRD analysis, ZnO nanorods with hexagonal wurtzite structures were successfully in-situ formed on BC surface. EDX analysis confirmed the presence of Zn and O, showing 54.1% and O 20.8% by weight on BC, respectively, and 32.24% of Zn was determined on BC surface using AAS measurements. The MIC values of antibacterial material were calculated 12.28 µg ZnO/mL for Escherichia coli (E. coli) and 6.28 µg ZnO/mL for Staphylococcus aureus (S. aureus) species. © 2025 Wiley-VCH GmbH.
Synthesis and characterization of a novel membrane based on poly (2-ethyl oxazoline) and poly (propylene) graft copolymer for potential food packaging and medical applications
(American Chemical Society, 2025) Hazer, Baki; Karahaliloğlu, Zeynep; Keleş, Özgür
Cost-effective olefin polymers have been producing several hundred million tons of olefins each year. They have material properties suitable for packaging and biomedical applications. Among them, chlorinated polypropylene (PP-Cl) was functionalized with poly(2-ethyl oxazoline) (PP-polyEtOx) to obtain a biomimetic PP-polyEtOx conjugate polymer material. Poly(2-ethyl oxazoline) is a water-soluble antibacterial and anticancer polymer. The combination of this bioactive polymer with the elastic properties of polypropylene via graft copolymerization provided a potential active food packaging material. Here, the obtained PP-polyEtOx graft copolymer was characterized structurally using 1H NMR, Fourier transform infrared (FTIR), and X-ray photoelectron spectroscopy (XPS). The water vapor transmission rates of the obtained membranes are better than those of polyethylene terephthalate membrane. Biologic active characterization of the block copolymer was carried out in view of the antibacterial and anticancer properties. The PP-polyEtOx graft copolymers caused a reduction in colony counts for both S. aureus and E. coli compared to the control. The as-synthesized PP-polyEtOx graft copolymers exhibited an inhibition of viability in HT-29 human colon adenocarcinoma cells. © 2025 The Authors. Published by American Chemical Society
