Aksaray Üniversitesi Kurumsal Akademik Arşivi
DSpace@Aksaray, Aksaray Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Evaluation of computational modeling approaches for continuous flow microwave processing of multiphase food products (solid-liquid mixtures)
(Elsevier B.V., 2025) Karataş, Ozan; Şahin, Kübra Bulduk; Uyar, Rahmi; Erdoğdu, Ferruh
Evaluation of conventional thermal processing for multiphase food products (e.g., solid – liquid mixtures) is based on the temperature change of the fastest moving particle. This leads to over-processing of other particles. While a proper process design is required, experimental temperature measurement is a difficult task. Hence, computational approaches should be preferred for this purpose. Besides this challenge, conventional processes are to be replaced with novel approaches for sustainability. Microwave (MW) heating might be considered as a novel approach, but its application in such a process increases the complexities in the view of non-uniform temperature distribution. Therefore, the objective of this study was to computationally evaluate the computational modeling approaches for determining the temperature distribution during MW processing of multiphase (solid – liquid mixture) food products for process design purpose. A commercial finite element solver was used for this purpose, and a process design study for a continuous flow MW process was also introduced. Pros and cons of particle tracing and moving mesh approaches were discussed, and an improved modeling approach was presented for process design of multi-particle continuous flow MW processing. The results of this study are expected to provide detailed information from the idea to the industrial scale application due to the designed process parameters.
Determination of the functional, nutritional, and some quality properties of kefir produced with the addition of germinated chickpeas
(John Wiley and Sons Ltd, 2025) Kahve, Ayşe Nur; Bayrak, Ebru
Global population growth and rising health consciousness have increased the demand for sustainable and functional foods. This study aimed to enhance the nutritional value of chickpeas (Cicer arietinum L.) and evaluate the functional and quality characteristics of kefir enriched with germinated chickpeas. Germination conditions were optimized, and chickpea samples were analyzed for protein, moisture, ash, and total phenolic content. Principal component analysis (PCA) identified the optimal germination parameters. Kefir samples were prepared by incorporating ungerminated chickpeas, inulin, or optimally germinated chickpeas at concentrations of 0.5%, 1%, and 2%, and stored at 4°C ± 1°C for 7 days. Physicochemical, microbiological, and sensory analyses were performed on Day 1 and 7. The highest protein (14.99%) and total phenolic content (9.05 mg GAE/g) were observed in chickpeas soaked for 12 h at 30°C and germinated for 72 h. Kefir pH values ranged from 4.01 to 4.75 (p < 0.05). Increasing the concentration of germinated chickpeas significantly improved the total phenolic content (p < 0.05), and yeast growth was detected exclusively in these samples (p < 0.05). However, sensory evaluation scores declined with higher chickpea concentrations. In conclusion, kefir enriched with germinated chickpeas demonstrates enhanced nutritional and microbiological properties, indicating its potential as a functional beverage. Nevertheless, further improvements are necessary to optimize its sensory characteristics for consumer acceptance.
Association between air pollution and climate parameters exposure during the periconceptional period and hypospadias risk in Turkish offspring: A case-control study
(Elsevier B.V., 2025) Demirtaş, Mehmet Semih; Yalçın, Sıddıka Songül; Tusat, Mustafa; Özmen, İsmail; Başar, Dilek; Calapoğlu, Ahmet Salih Calapoglu, Ahmet Salih lu, Ahmet Salih; Siyve, Serdar; Demirtaş, Orhan; Altıntaş Ural, Dilan
We aimed to investigate the associations between hypospadias and contact to air pollutants and climate parameters during the pre- and post-conceptional periods. This study has been carried out as a multicentre case-control study involving 340 children with hypospadias between the ages of 0–3 years and 357 children in the same age range who applied for circumcision. A total of 7 air pollutant (PM2.5, PM10, NO, NO2, SO2, CO, O3), 5 climate parameters [air temperature, relative humidity (RH), air pressure (AP), wind speed (WS) and precipitation amounts data were obtained. In the multivariate logistic regression analysis, younger maternal age (reference: >35 years) and maternal smoking (reference: no exposure) were significantly associated with a higher likelihood of hypospadias. Conversely, folic acid supplementation intake during pregnancy (reference: no supplementation) and maternal BMI in the range of 25–30 (reference: <25) were associated with a lower likelihood of its occurrence. After adjusting for child-family characteristics, increased interquartile ranges (IQR) of CO, mean temperature, minimum temperature, RH, and AP were positively associated with hypospadias, whereas SO2 levels and diurnal temperature range (DTR) were inversely associated. Comprehensive analysis of individual and environmental factors further highlighted that younger maternal age, smoking exposure, PM10, and air pressure were positively associated with hypospadias, while a greater DTR was inversely associated. Younger maternal age, smoking exposure, and specific air pollutants, such as PM10 and CO, as well as climatic factors like AP, were positively associated with hypospadias. These findings underscore the importance of mitigating environmental exposures and promoting maternal health interventions to reduce the risk of congenital anomalies like hypospadias. Further longitudinal studies are warranted to confirm these associations and explore underlying mechanisms.
Yeşil bilişim farkındalığı: örnek bir webuygulaması
(Aksaray Üniversitesi, Sosyal Bilimler Enstitüsü, 2025) Yavuz, Fatmanur
Çağımızda dijitalleşme bireylerin, kurumların ve toplumların yaşam biçimlerini yeniden şekillendiren, hızlı ve sürekli bir dönüşüm sürecidir. Bilişim teknolojilerinin giderek yaygınlaşması bilgiye erişimi kolaylaştırmanın, iş süreçlerini optimize etmenin ve yenilikçi çözümler sunmanın ötesinde ekonomik, sosyal ve çevresel alanlarda önemli etkiler oluşturmuştur. Sürekli artan enerji tüketimi, elektronik atıkların hızla artan hacmi ve karbon salınımı bilişim teknolojilerinin çevre üzerindeki olumsuz etkileri arasında öne çıkmaktadır. Yeşil bilişim, bilişim teknolojilerinin üretiminden kullanımına ve geri dönüşüm süreçlerine kadar tüm yaşam döngüsünü kapsayan çevre dostu bir anlayışı ifade etmektedir. Yeşil bilişim farkındalığı, bilişim teknolojilerinin çevresel etkilerini azaltma ve sürdürülebilirlik hedeflerine katkıda bulunma açısından hayati bir öneme sahiptir. Bununla birlikte, bilişim teknolojilerinin kullanımının artmasına rağmen, işletmeler arasında yeşil bilişim konusundaki farkındalık düzeyinin yetersiz olduğu göze çarpmaktadır. Bu çalışmada işletmelerin yeşil bilişim konusundaki farkındalıklarını artırmak ve çevresel sürdürülebilirlik süreçlerine katkı sağlamak amacıyla bir web sitesi tasarlanmıştır. Web sitesi HTML, CSS, JavaScript, Bootstrap ve PHP gibi web tasarımı ve geliştirme dilleri kullanılarak oluşturulmuştur. Site, yeşil bilişimin temel kavramları, sürdürülebilir teknolojiler, e-atık yönetimi, karbon ayak izinin azaltılması, ekolojik etiketler gibi konulara yönelik bilgi sağlayarak kullanıcılara çevre dostu teknolojilere geçişte ve yeşil bilişim bilincini artırmada katkı sağlamaktadır. Araştırma sürecinde web sitesinin etkinliğini artırmak ve yeşil bilişim içeriklerini daha iyi sunmak amacıyla dört uzmandan geri bildirim alınmıştır. Uzman görüşleri doğrultusunda içerik, görseller, yazım hataları ve SEO optimizasyonu açısından revizyonlar yapılmıştır. Bu düzenlemeler siteyi daha anlaşılır ve işlevsel hale getirmiştir. Gelecekte yapılacak çalışmalarla yeşil bilişimin toplumsal, çevresel ve ekonomik katkılarının daha belirgin hale gelmesi ve bu alandaki farkındalığın artması beklenmektedir.
Antiviral activities of phenylalanine derivatives carrying carboxylic acid bioisosteres against chikungunya and parainfluenza virus type 3
(Elsevier Ltd, 2025) Eren, Merve Camcı; Güngör, Görkem; De Jonghe, Steven; Özbil, Mehmet; Neyts, Johan; Kaptein, Suzanne; Şenol, Halil; Köse, Aytekin; Gezginci, Mikail Hakan; Karalı, Nilgün
Pathogenic RNA viruses from various virus families represent substantial public health hazards. Specific antiviral drugs effective against most RNA virus infections have not yet been developed. In this study, it was aimed to investigate the broad-spectrum antiviral activities of phenylalanine derivatives designed by replacing the carboxylic acid moiety with various bioisosteres such as nitrile, hydroxamidine and 5-oxo/thioxo-1,2,4-oxadiazole. Novel synthesized N-(1-substituted 2-phenylethyl)-N-(3-chlorobenzyl)-2,4-dichlorobenzamides (6e, 7e, 8e and 9d), together with phenylalanine derivatives previously prepared by our group, were evaluated antiviral activities against chikungunya (CHIKV), Zika (ZIKV), parainfluenza virus type 3 (PIV3), and enterovirus 71 (EV71). All phenylalanine derivatives showed antiviral activities against PIV3, with the 3-fluorobenzyl substituted analogue 6d emerging as the most potent compound (IC50 = 3.74 μM, CC50 > 100 μM), whereas the 3-chlorobenzyl analogue 6e (IC50 = 5.72 μM, CC50 > 100 μM) possessed the best non-toxic antiviral activity against CHIKV. Combined molecular docking and molecular dynamics (MD) simulation studies were conducted to predict the interactions of compounds 6d and 6e with the possible viral proteins of PIV3 and CHIKV, respectively.
