Cilt 4, Sayı 2, Makale Koleksiyonu

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https://hdl.handle.net/20.500.12451/11281

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Histerektomize Vajinal Cuff Prolapsusu Olan Hastaya Carter-Thomason Operasyonu: Olgu Sunumu
(Aksaray Üniversitesi, 2023) Şahin, Buğra; Cura Şahin, Gizem
Günümüzde insan yaşam süresi uzamakla beraber, kadın yaşam süresi uzamaktadır. Kadınlar yaşamlarına daha etkin olarak devam etmektedir. İlerleyen yaşa bağlı pelvik doku zayıflaması ve sayısı artan histerektomi ameliyatları sonrasında vaginal cuff prolapsusu görülme ihtimali de artmaktadır. Bundan dolayı yapılan ek ameliyat gereksinimi de artmaktadır. Carter-Thomason operasyonu, round ligamentlerin eleve edildiği uterin prolapsusu ortadan kaldıran cerrahi bir yöntemdir. Yaklaşık 5 yıl önce vajinal histerektomi operasyonu yapılmış olan 80 yaşındaki kadın hastamıza kronik vajınal prolapsusu nedeniyle laparotomik olarak Carter-Thomason operasyonu uygulandı. Bizim bu metodu uygulamamızın nedeni daha önceden yapılan histerektomiye bağlı olarak douglusa ve sakruma yapışıkların gözlemlenmesi ve bu yapışıklıkların açılaması nedeniyle batın fasyasına histerektomiden kalan round ligament kalıntıları suspansiyonu işlemi yapıldı. Bizim olgu sunumumu yapmamızın nedeni ise; bu yöntemin uterin prolapsusu olan hastalarda kullanılmasına rağmen, vajinal cuff prolapsusu olanlarda Carter-Thomason operasyonu tekniğinin kullanılmadığıdır. Bu yöntemin nadir olarak uygulanmaması nedeniyle Carter-Thomason operasyonunu son literatür bilgileri eşliğinde bu olgumuzda tartışmayı planladık.
Akut iskemide İşbirliği ile Mezenter Arter Trombektomi, Balon ve Stent Uygulaması Olgusu
(Aksaray Üniversitesi, 2023) Göçer, Hakan; Durukan, Ahmet Barış; Serim, Çetin
Akut mezenter arter tıkanıklığı morbiditesi ve mortalitesi yüksek bir abdominal patolojidir. Akut mesenter iskemisi olan comorbiditesi yüksek hastada acil şartlarda cerrahiye alternatif olarak mezenter arter girişimleri yapılmaktadır. Bu girişimler hastayı cerrahi riskten korur. Mevcut çalışmalar ışığında bu girişimler acil şartlarda koroner için yapılmış malzemelerle uygulanabilir. Burada, akut mezenter trombozu olan morbid obez ve risk faktörleri dolayısıyla cerrahi yerine trombektomi, balon ve stent uygulanıp tam şifa ile taburcu edilen olguyu sunuyoruz
Anaflaksi sonrası gelişen parkinsonizm olgusu
(Aksaray Üniversitesi, 2023) Algül, Fatma Ebru; Ünver, Fatma Beyza; Tomul, Helin Özüm
Giriş: Bazal ganglionlar perfüzyon sınır bölgesinde yer almaları nedeni ile akut ve kronik hipoksik-iskemik durumlara oldukça duyarlı bölgelerdir. Yapılan çalışmalar hipoksinin PH gibi nörodejeneratif hastalıklara yol açabildiğini göstermiştir. Anafilaksi böcek ısırması, arı sokması nedeni ile oluşabilen, birçok organın etkilendiği, ölüm ve hipoksi ile sonuçlanan hipersensitivite reaksiyonudur. Biz de arı sokması nedeni ile anafilaksi ve kardiak arrest gelişen, taburcu edildikten sonra takiplerinde parkinsonizm gelişen bir olguyu nadir görülmesi nedeni ile sunmayı planladık. Olgu: 58 yaşında erkek hasta, arı sokması, anaflaksi sonrası kardiak arrest gelişen hasta 1 haftalık entübasyon süresinden sonra extübe edilmiş. Sonrasında hareketlerde yavaşlama, REM uyku davranış bozukluğu ve unutkanlık şikayeti olması üzerine tarafımıza konsülte edildi. Nörolojik muayenede bradimimi, solda daha belirgin bilateral bradikinezi, bilateral rijidite tespit edildi. Adım aralığının daralmış, postüral instabilitenin pozitif olduğu tespit edildi. Yapılan nöropsikolojik testte özellikle yürütücü işlevlerde bozulma olduğu görüldü. Yapılan kranial MR görüntülemesinde bilateral nukleus kaudatus, putamen ve globus pallidusta T2 ve T2 flair simetrik hiperintens lezyon olduğu izlendi. Donepezil ve levodopa tedavisi başlanıldı, tedaviden kısmen fayda gören hasta poliklinik kontrolüne alındı. Sonuç: Bazal ganglion fonksiyonunu bozan, dopaminerjik nöron işleyişine hasar veren tüm durumlar parkinsonizm tablosuna yol açabilmekte olup tanı ve tedavi yönetimi zor olmaktadır. Gelecekte raporlanacak daha çok vaka ile tanı için kesin kriterler belirlenebilecek ve daha net tedavi planları yapılabilecektir.
Isolated right ventricular myocardial infarction in a patient with secundum atrial septal defect: A rare case
(Aksaray Üniversitesi, 2023) Aktaş, Halil; Gül, Murat; Yıldırım, Oğuz; İnci, Sinan
Right ventricular myocardial infarction is a serious emergency that causes haemodynamic disturbances as a result of sudden right ventricular systolic dysfunction and dilatation. 25% to 50% of inferior wall myocardial infarction cases are accompanied by right ventricular myocardial infarction. Atrial septal defect is a congenital anomaly that causes shunt between the atria and can cause dilatation of the right atrium and ventricle. Right ventricular myocardial infarction has been rarely reported in a patient with atrial septal defect previously. In addition, isolated right ventricular myocardial infarction was not reported in a patient with atrial septal defect. In this article, we present a 56-year-old patient with previously undiagnosed secundum atrial septal defect presenting with isolated right ventricular myocardial infarction.
Perinatal Outcomes of Refugee Mothers and Newborns in the Tenth Year of Migration
(Aksaray Üniversitesi, 2023) Kılıçaslan, Cengizhan; Ateş, Can; Kılıçaslan, Murat
Introduction: Millions of individuals from underdeveloped countries live as refugees after increasing migration events. In the 10th anniversary of the migration commencing in 2011, we aimed to evaluate the health status of refugees and examine refugees’ birth rates and babies’ health born in our country. Methods: 2983 births were examined retrospectively, using file and hospital information system data. Maternal age, number of pregnancies, duration of pregnancy, babies’ anthropometric measurements, and mode of deliveries were evaluated. Results: Of 2893 births analyzed, 2435 and 458 births were given by Turkish citizens and refugees respectively. Number of pregnancies was high among refugees (p<0.001). Although no statistical significance was detected in late pre-term, term, and post-term birth rates, early pre-term and pre-term births were found to be significantly higher in refugees (p<0.001); normal births were higher in refugees. Discussion and Conclusion: The increasing number of refugees and increasing migration events are among important health challenges. Fertility rates due to the increasing population of refugees also increase the number of pregnancies and premature births. The lack of health insurance accompanying the economic problems of refugees comes to the fore as another important problem in countries hosting refugees.
COVID-19 Vaccination Behavior in Healthcare Professionals with At least 2 Doses of COVID-19 Vaccination After Sars-CoV-2 Omicron Variant
(Aksaray Üniversitesi, 2023) Gürer Giray, Burcu; Güven Açık, Gökçe
AIMS: Health workers are priority individuals because they take part in primary health care services, and they are a very high-risk group for infectious diseases and pandemics. Behaviors of health workers as role models in society towards vaccines and treatments can significantly affect their efforts to fight against a disease or to contain and terminate a pandemic. METHODS: This study aimed to determine healthcare workers’ COVID-19 vaccine attitude who had positive Sars-CoV-2 omicron variant after receiving at least 2 vaccine doses. The population of this decisive study consisted of healthcare workers who had positive Sars-CoV-2 after at least 2 doses of vaccine and volunteered to participate in the study. The study reached 532 healthcare professionals and a cross-sectional study was conducted as an online questionnaire between 15-28 October 2022. RESULTS: It was determined that 340 (63.91%) of them were female and 192 (36.09%) were male. 224 (42.11%) were laboratory technicians, 198 (37.22%) were other healthcare professionals,78 (14.66%) were biologists and 32 (6.02%) were physicians. 364 (68.42%) of them did not have chronic disease and 35.71 % of those with chronic disease had hypertension. Sars-CoV-2 variant was not detected for the 32 (6.02%) who were COVID-19 positive. 508 (95.49%) of the participants received 3 doses of COVID-19 vaccine and 400 (75.19%) preferred BioNTech vaccine for the third dose. CONCLUSION: Multi-faceted data compilation of supportive and informative approach for vaccine encouragement among healthcare workers is determined to be very significant. Healthcare workers should be provided with accurate and up-to-date scientific information to evaluate effectiveness of vaccines.
Investigation of COL12A1 Gene Polymorphism Profile in Genetic Injury Susceptibility in Football Players Having Anterior Cruciate Ligament Surgery
(Aksaray Üniversitesi, 2023) Şahin, Kübra; Bozkurt, Nihan; Şavkın, Sadegül; Bülbül, Alpay; İpekoğlu, Gökhan; Çakır, Halil İbrahim
Aim: Risk factors such as repetitive traumas, overloads, turning, sliding movements, muscle weakness, excessive training intensity and duration, and faulty training in football invite anterior cruciate ligament injuries in athletes. In this context, it is thought that determining the gene profiles of football players to increase their performance and avoid injuries will make a serious contribution to the field in terms of both performance and athlete health. Although the etiology of the molecular mechanisms is not fully understood, many risk factors are associated with anterior cruciate ligament tears, including genetic factors, genes involved in the repair process such as MMPs, or components of the apoptosis pathway. In this study, the relationship between COL12A1 gene polymorphism and anterior cruciate ligament injury in football players who underwent cruciate ligament surgery was investigated. Materials and Methods: 41 patients who had Anterior cruciate ligament (ACL) surgery and 65 age-sex-matched healthy individuals were investigated for COL12A1 A/G polymorphism. Genotyping of COL12A1 A/G was determined using PCR-RFLP. Statistical analysis of the data was done with Epi Information Software and Arlequin Software. A value of p < 0.05 was considered statistically significant. Results: Our study findings showed that there was no significant difference between the patient and control groups in terms of allele frequency and genotype distribution of the COL12A1 polymorphism (p=0.880). Conclusion: The findings of this study suggested that COL12A1 (rs970547) was not associated with susceptibility to anterior cruciate ligament injuries in the Turkish population.
Investigation of the Effect of Serotonin on Proliferation of Adipose Tissue-Derived Mesenchymal Stem Cells via Wnt-? Signaling Pathway
(Aksaray Üniversitesi, 2023) Semerci Sevimli, Tuğba; Demir Cevizlidere, Bahar; Ghorban, Aynaz; Gakhiyeva, Fidan; Sevimli, Murat
Aim: Mesenchymal stem cells (MSCs) are among the most studied cells due to their properties in terms of cellular therapies. In particular, the continuity of MSCs is essential in clinical studies. The Wnt signal plays a vital role in regulating the proliferation and differentiation of MSCs. In this study, the effect of serotonin (5-hydroxytryptophan [5-HT]) on the proliferative properties of adipose tissue-derived MSCs (AD-MSCs) was investigated through the Wnt-? signaling pathway. Materials and Methods: AD-MSCs were used in the study. Firstly, the effect of serotonin concentrations ranging from 1-100 µM on AD-MSCs was analyzed by MTT test. The apoptotic effect on the cells was determined by Annexin V/PI analysis. Finally, the expression levels of WNT2, AXIN, and CTNNB1 genes were analyzed at the molecular level by qPCR. Results: The MTT analysis revealed that 75 µM serotonin reduced proliferation at 48 hours. After 48 hours of treatment with 75 µM serotonin, the apoptotic cell rate increased to 2.05%, while the early apoptotic cell rate was determined as 0.77%. When compared with the control group, WNT2, and AXIN gene expressions were up-regulated (p<0.05), while the CTNNB1 expression was down-regulated in the cells treated with serotonin (p<0.01). Conclusion: The results show that serotonin can increase the proliferative effect of mesenchymal stem cells through the Wnt signaling pathway. However, further in vivo and advanced molecular studies are required to support these findings.

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