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Öğe Biomedical applications of layer-by-layer self assembly(Nova Science Publishers, Inc., 2020) Bozdoğan, Betül; Daban, Gizem; Denkbaş, Emir BakiLayer-by-layer (LbL) self-assembly is the most widely used strategy for the production of functional surfaces with tailored structures and properties such as chemical, biological, optical and electrical. This strategy involves alternately coating the planar or colloidal surfaces with complementary compounds such as oppositely charged polyelectrolytes, inorganic molecules, metal oxides, silica colloids, dyes, clays, nanostructures or biologically active species like enzymes, DNA, viruses, or proteins. The assembly process is driven by noncovalent interactions under mild conditions. LbL is independent of the substrate shape, size or type; environmentally-friendly; high loading capacity of different types of biomolecules into films; allows room temperature processing and low-cost manufacturing. These outstanding advantages of LbL self-assembly make it especially attractive in the biomedical applications. LbL approaches open new horizon for design biocompatible, antimicrobial, hydrophobic, hydrophilic, electrically conductive, chemically stable, hydrolyzable, adhesive, non-adhesive, anti-thrombotic, semipermeable, stimuli-sensitive surfaces and for loading bioactive molecules to design tissue scaffolds, cardiovascular devices, implants, wound healing dressing, bone grafts, biosensors, drug delivery, and release systems.Öğe Molecular imprinting technology for sensing and separation in food safety(Wiley, 2016) Ulusoy, Baran Önal; Odabaşı, Mehmet; Aksoy, Neşe HayatFor nearly four decades, molecularly imprinted polymers (MIPs), a type of artificially nanostructured material, have captured the attention of many scientists as a result of their ease of preparation and utilization, as well as their nominal cost and high selectivity for target molecules in different areas of analytical chemistry and biochemistry. MIPs can be used to build various molecules, enabling designs for various target molecules, such as toxic and deleterious substances, drug and pesticide remnants, heavy metals and peptides, as well as high-molecular-weight biomolecules, such as viruses, cells, and proteins. Molecular imprinting technologies with identification skills, like the ambidextrous kit, can be applied to a wide range of areas including chromatography, chemical sensors, and food analysis for food safety purposes. Due to the non-selective cleanup and time-consuming procedures, it is difficult to examine trace analytes in the food matrix. Food safety during production, transportation, storage, and consumption is increasingly important in worldwide. Thus, novel methods and technologies are being developed to control food safety, particularly as it related to human health. In this chapter, we have compiled recently published and novel studies, focusing on the sensing/separation of food safety and the evaluation of detrimental substances utilizing molecular imprinting technologies.
