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https://hdl.handle.net/20.500.12451/344

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    Determination of both the expression and serum levels of EGF and TGFβ1 genes in SARS-CoV-2
    (Open Journal of Respiratory Diseases, 2024) Gülhan, Pınar Yıldız; Eröz, Recep; Öztürk, Cihadiye Elif; Yekenkurul, Dilek; Altınsoy, Hasan Baki; Balbay, Ege Güleç; Erçelik, Merve; Davran, Fatih; Yıldız, Şeyma
    We aimed to evaluate the effects of both the expression and serum levels of Epidermal growth factor (EGF) and Transforming growth factor-β1 (TGF-β1) genes in patients with different degrees of cellular damage as mild, moderate, severe, and critical illness that can lead to fibrosis caused by SARS-CoV-2. Totally 45 individuals (male: 21(46.67%); female: 24(53.33%)) with COVID-19 infection were included in this study. Four groups were constituted as mild (n = 16)], moderate (n = 10), severe (n = 10), and critical (n = 9) according to the severity of the disease. Blood samples were drawn from the patients, and all of the hemograms, EGF and TGFβ1 gene expression, and serum levels were evaluated. The mean age of individuals was 57.311 ± 18.383 (min: 28, max: 94). Significant differences were found among the groups for PLT (χ2 = 9.955; p = 0.019), CRP (χ2 = 7.693; p = 0.053), Ferritin (χ2 = 22.196; p < 0.001), D-dimer (χ2 = 21.982; p = 0.000), LDH (χ2 = 21.807; p < 0.001) and all these parameters (exclude PLT in severe groups) was increased depending on the severity of the disease. Additionally, significant differences were detected for EGF (χ2 = 29.528; p < 0.001), TGFB1 (χ2 = 28.981; p < 0.001) expression (that increased depending on the disease severity), and EGF (χ2 = 7.84; p = 0.049), TGFB1 (χ2 = 17.451; p = 0.001) serum concentration levels (that decreased depending on the disease severity). This study found statistically significant differences for both EGF 2−ΔΔCt. TGFβ1 2−ΔΔCt and EGF, TGFβ1 serum concentration values among all patient groups. As disease severity increased, EGF 2−ΔΔCt. TGFβ1 2−ΔΔCt levels increased, while EGF and TGFβ1 serum concentration levels decreased. Perhaps this study will be useful in managing COVID-19 infection severity and pulmonary fibrosis cases secondary to COVID-19.
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    Thiol/disulfide homeostasis as a new oxidative stress marker in patients with neonatal transient tachypnea
    (Bayrakol Medical Publisher, 2023) Erdal, Hüseyin; Demirtas, Mehmet Semih; Tuncer, Sibel Çigdem; Özcan, Oğuzhan
    Transient tachypnea of the newborn (TTN) is the most common cause of respiratory distress occurring in delayed clearance of lung fluid. This is the first report to examine thiol-disulfide homeostasis in patients with TTN.Material and Methods: Thirty TTN and 30 controls were included in the present study. The dynamic thiol-disulfide balance was determined by the new colorimetric method developed by Erel et al. TAS, TOS and OSI levels were evaluated using the previously described method developed by Erel.Results: Thiol levels were found to be significantly lower between patient and the control groups. However, disulfide levels were not significantly higher in the TTN group compared with the control groups. Disulfide/native thiol, disulfide/total thiol and native/total thiol levels were statistically significantly different between the TTN and control groups. Moreover, we found that TAS, TOS and OSI levels were also statistically significantly different between patient and control groups.Discussion: This study indicates that the measurement of dynamic thiol-disulfide homeostasis may contribute to the pathophysiological mechanism, and follow-up of the disease in patients with TTN. In addition, increased TOS and decreased TAS levels may be related with increased oxidative stress and a functional reduction of antioxidant defense system.
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    Patients non-covıd-19 diagnosis in pandemic clinics: three case reports
    (Ayşe SURUÇ, 2022) Özdemir, Serdar; Akça, Hatice; Altunok, İbrahim; Algın, Abdullah; Kokulu, Kamil
    With the pandemic process, the frequency of clinicians' referrals for thoracic imaging has increased. In this article, three cases diagnosed other than COVID-19 in pandemic clinics are presented. A 33-years-old male admitted to the pandemic clinic with sore throat and dyspnea for two days. A large pneumothorax was observed on thorax imaging. The tube thoracostomy was performed. The patient was discharged after 14 days of follow-up. A 31-years-old female patient was admitted to pandemic clinic with the complaints of exertional dyspnea, cough, sore throat and abdominal pain for two weeks. Massive effusion was observed on thorax imaging. As a result of further examinations, the patient was diagnosed with metastatic colon carcinoma. An 18-years-old male patient was admitted to the pandemic clinic with chest pain lasting for a day. Mediastinal emphysema was observed on thorax imaging. The increased number of thoracic imaging during the pandemic process will lead to an increase in the incidence of asymptomatic and subclinical thoracic pathologies. This increase of incidence should be reveled with further epidemiological studies.
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    Management of a rare case: transverse testicular ectopia associated with persistent mullerian duct syndrome
    (Ankara Üniversitesi, 2021) Demirtaş, Mehmet Semih; Tuşat, Mustafa
    Transverse testicular ectopia (TTE) is a rare congenital anomaly in boys, which is characterized by the migrate of both testicles towards the same hemiscrotum or inguinal region. TTE cases are accompanied by the characterized persistent mullerian duct syndrome, which is phenotypically male, with the presence of mullerian duct structures. Persistent Müllerian duct syndrome is caused either by the genetic defect of the anti-mullerian hormone or its receptor. In this case, we reported a TTE associated with persis-tent mullerian duct syndrome in a 12-year-old boy who presented with swelling in the right groin and non-palpable left testis. The patient was treated with high ligation of the hernia sac, excision of mullerian structures and transseptal orchiopexy. In the surgical approach of the cases, we think that removing the mullerian structures as much as possible and making the testicles palpable without damaging the testicles and other adjacent structures are important.
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    Tattoos in dermatology: demographics, motivations, tattooing practices
    (Wiley, 2021) Kıvanç Altunay, İlknur; Gülsunay, İlayda E.; Özkur, Ezgi; Aydın, C.; Manav, Vildan; Özden, Hatice Kaya; Çalıkoğlu, E. E.; Ertekin, S. S.; Erdoğan, Hilal; Taşkın, Banu; Kuru, S.; Memet, B.
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    Lipid lowering therapy use in secondary prevention: an analysis of ephesus study
    (Elsevier, 2019) Başaran, O.; Doğan, V.; Mert, G. O.; Mert, K. U.; Özlek, B.; Çelik, O.; Özlek, E.; İnci, Sinan
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    Assessment of nutritional status and bowel habits in osteoporosis: A cross-sectional, multicenter study of turkish elderly female population
    (Springer, 2019) Karahan, A. Y.; Bağçacı, S.; Ordahan, B.; Sevinç, B.; Özkük, K.; Kuran, B.; Şahin, N.; Karakoyun, Ahmet; Salbaş, E.; Ketenci, S.
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