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Öğe A review on exopolysaccharide production by Lactobacillus acidophilus and their techno-functional applications in food and pharmaceutical industry(Innovative Scientific Information and Services Network, 2023) Dailin, Daniel Joe; Bing, Loo Yoo; Hanapi, Siti Zulaiha; Yenn, Tong Woei); Zailani, Siti Nazrah; Çamkerten, İlker; Sukmawati, Dalia; El Enshasy, Hesham AliBacterial exopolysaccharides (EPS) are renowned for their technical and functional applications in the food and pharmaceutical industry.EPS retrieved from Lactobacillus sp.is one of the bacterial groups that have garnered a great deal of attention by showing its unique behaviors by expressing their ability to promote health benefits. The EPS from Lactobacillus acidophilus finds application in many areas like food, pharmaceuticals, bioremediation, cosmetics, and others. As EPS produced by Lactobacilli has conferred a range of local and systemic health benefits on the host, synthesis of these metabolites through fermentation should be emphasized. An optimal and cost-effective fermentation process by understanding the parameters and conditions is crucial in optimising the EPS yields. This review gives an overview of the biosynthesis of the EPS and the factors influencing the production of the EPS. Finally, techno-functional applications in food and pharmaceutical products associated with EPS are discussed.Öğe Investigation of ischemia-modified albumin and thiol/disulfide homeostasis for the determination of oxidative stress in sheep with toxoplasmosis(Elsevier B.V., 2023) Aydın, Ömer; Özkurt, Güzin; Çamkerken, İlker; Eren, Emre; Yanar, Kerim Emre; Aktaş, Mustafa SinanIn this study, the aim was to investigate the thiol/disulfide homeostasis (TDH) parameters and ischemia-modified albumin (IMA) (ABSU) levels to determine oxidative stress in sheep with toxoplasmosis. Twenty-four Morkaraman sheep used in this study were allocated into two groups, one control group and one experimental group. Each group included 12 sheep. Blood samples were taken from all sheep only once and blood serum levels of albumin (ALB) (g/L), IMA (ABSU), native thiol (NT) (?mol/L), total thiol (TT) (?mol/L), disulfide (Ds) (?mol/L), Ds/NT, Ds/TT, NT/TT were investigated. Our results showed that the IMA (ABSU) levels of toxoplasma group were significantly higher than control group (p < 0.05). However, NT (?mol/L) and TT (?mol/L) level of toxoplasma group were significantly lower than the control group (p < 0.05). While the oxidant and antioxidant parameters were positively correlated within themselves, a negative correlation was determined between the antioxidant and oxidant parameters. In the Receiver Operating Characteristic (ROC) analysis, the area under the ROC curve (AUC), sensitivity, cut off and specificity values were determined for IMA (ABSU) values. These values were determined as 0.812, 1.24, 91.7% and 75.0%, respectively. For TT (?mol/L), these values were obtained as 0.750, 330.55, 75.0% and 66.7%. It was concluded that oxidative stress is intensely formed in sheep with toxoplasmosis, thiol-disulphide homestasis markers, and IMA (ABSU) are valuable markers in determining oxidative stress in toxoplasmosis.
