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  • Küçük Resim
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    Investigation of ischemia-modified albumin and thiol/disulfide homeostasis for the determination of oxidative stress in sheep with toxoplasmosis
    (Elsevier B.V., 2023) Aydın, Ömer; Özkurt, Güzin; Çamkerken, İlker; Eren, Emre; Yanar, Kerim Emre; Aktaş, Mustafa Sinan
    In this study, the aim was to investigate the thiol/disulfide homeostasis (TDH) parameters and ischemia-modified albumin (IMA) (ABSU) levels to determine oxidative stress in sheep with toxoplasmosis. Twenty-four Morkaraman sheep used in this study were allocated into two groups, one control group and one experimental group. Each group included 12 sheep. Blood samples were taken from all sheep only once and blood serum levels of albumin (ALB) (g/L), IMA (ABSU), native thiol (NT) (?mol/L), total thiol (TT) (?mol/L), disulfide (Ds) (?mol/L), Ds/NT, Ds/TT, NT/TT were investigated. Our results showed that the IMA (ABSU) levels of toxoplasma group were significantly higher than control group (p < 0.05). However, NT (?mol/L) and TT (?mol/L) level of toxoplasma group were significantly lower than the control group (p < 0.05). While the oxidant and antioxidant parameters were positively correlated within themselves, a negative correlation was determined between the antioxidant and oxidant parameters. In the Receiver Operating Characteristic (ROC) analysis, the area under the ROC curve (AUC), sensitivity, cut off and specificity values were determined for IMA (ABSU) values. These values were determined as 0.812, 1.24, 91.7% and 75.0%, respectively. For TT (?mol/L), these values were obtained as 0.750, 330.55, 75.0% and 66.7%. It was concluded that oxidative stress is intensely formed in sheep with toxoplasmosis, thiol-disulphide homestasis markers, and IMA (ABSU) are valuable markers in determining oxidative stress in toxoplasmosis.
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    Oxidative stress parameters in dogs naturally infected with sarcoptic mange
    (Facultad de Ciencias Agrarias UdeA, 2023) Yanar, Kerim Emre; Küçükler, Sefa; Eren, Emre; Eroğlu, Muhammed Sertaç; İIgün, Murat; Gür, Cihan; Kandemir, Fatih Mehmet; Aktaş, Mustafa Sinan
    Scabies is one of the most common diseases in dogs. It threatens both animals and humans due to its zoonotic potential. Objective: The purpose of this study was to evaluate the oxidant/antioxidant balance with hematological findings in dogs infested with sarcoptic mange. Methods: The animals evaluated in this study consisted of 32 mixed-breed dogs between 1 and 2 years of age. The dogs were allocated into two groups: a control group (infestation-free animals; n=10), and a sarcoptic mange-infected group (Sarcoptes, n=22). Dogs in the Sarcoptes group showed infestation signs such as intense itching, excoriations, alopecia, and blistering of the elbow and auricular margins. Results: Significant increase (p<0.01) levels were observed in total oxidant status (TOS), malondialdehyde (MDA), oxidative stress index (OSI), and nitric oxide (NO), while glutathione (GSH) and total antioxidant status (TAS) levels in dogs infested with Sarcoptes decreased significantly (p<0.01). In addition, a significant increase (p<0.01) of WBC count in dogs in the sarcoptic group in comparison with the control was found. Conversely, there was significant decrease (p<0.01) in RBC, HGB, and PCV counts in Sarcoptes-infested dogs. Conclusions: Our study suggests a possible relationship between oxidant/antioxidant imbalance and hematological findings in dogs infested with sarcoptic mange. Furthermore, in addition to MDA, TAS, TOS, and OSI markers, NO as well as GSH might be also used to assess the oxidative stress in dogs naturally infected with Sarcoptes scabiei.
  • Küçük Resim
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    Prognostic potential of inflammatory markers, oxidative status, thrombocyte indices, and renal biochemical markers in neonatal calf diarrhoea-induced systemic inflammatory response syndrome
    (Elsevier, 2023) Yanar, Kerim Emre; Eren, Emre; Aktaş, Mustafa Sinan; Eroğlu, Muhammed Sertaç; Kandemir, Özge; AydIn, Gürsel
    The study aimed to assess the prognostic value of inflammatory markers, indicators of oxidative stress, thrombocyte indices, and renal biochemical markers in neonatal calf diarrhoea (NCD) induced by systemic inflammatory response syndrome (SIRS) upon admission. A prospective, observational, and case-control study was conducted on 56 calves diagnosed with NCD. Mean concentrations of interleukin-6 (IL-6), malondialdehyde (MDA), glutathione (GSH), mean platelet volume (MPV), platelet distribution width (PDW), blood urea nitrogen (BUN), and creatinine (Crea) were measured. Furthermore, the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were also calculated for SIRS survivors [SIRS (survivor)] and non-survivors [SIRS (non-survivor)] induced by NCD. A prognostic cut-off value for predicting the prognosis of the SIRS's induced by NCD was obtained via receiver operating characteristic (ROC) curve analysis. Upon admission, the SIRS (non-survivor) calves had significantly higher (P < .001) average levels of IL-6, MDA, BUN, Crea, MPV, and PDW compared to the SIRS (survivor) calves and significantly lower (P < .001) average levels of GSH. Despite an apparent increase in the NLR and PLR values of calves diagnosed with SIRS, no significant difference was found between the survival and non-survivor SIRS cases. Positive predictive values (PPVs) for survival were determined as 100 %, 100 %, 80 %, 100 %, 80 %, and 80 %, respectively, using cut-off values of IL-6 (<259.67 ng/L), MDA (<2.87 nmol/mL), MPV (<12.5 fL), PDW (<34.25 %), BUN (<168.3 mg/dL), and Crea (<2.11 mg/dL). The determined threshold values are those obtained upon admission to the hospital. Based on the sensitivity, specificity, and PPVs derived from the ROC analysis, it has been concluded that IL-6, MDA, MPV, PDW, BUN, and Crea are the most relevant biomarkers used for predicting the prognosis of NCD-induced SIRS in calves. Furthermore, it is also noteworthy that IL-6 exhibited the highest effectiveness among all biomarkers.