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Öğe A rare case of secondary syphilis presenting with extensive cutaneous nodules and generalised lymphadenopathy(Acıbadem Üniversitesi, 2021) Tamer, Funda; Yüksel, Mehmet Eren; Akgül, GülşahSyphilis is an infectious disease caused by the spirochete Treponema pallidum. Syphilis is divided into clinical stages including primary, secondary, latent and tertiary syphilis. Secondary syphilis can present with various mucocutaneous lesions and multisystem involvement. Since it can mimic many other diseases, syphilis is known as ‘the great imitator’. However, secondary syphilis with nodular lesions is very rare. Moreover, nodular secondary syphilis can be misdiagnosed as syphilitic nodules of the tertiary stage. Hereby, we report an unusual presentation of secondary syphilis characterized by extensive erythematous nodules and generalised lymphadenopathy in an immunocompetent 39-year-old Caucasian male patient.Öğe All pilonidal sinus surgery specimens should be histopathologically evaluated in order to rule out malignancy(Elsevier Ltd., 2019) Yüksel, Mehmet Eren; Tamer, Funda...Öğe Does vitamin D deficiency cause direct inguinal hernia? preliminary results(Acıbadem Üniversitesi, 2021) Yüksel, Mehmet Eren; Tamer, Funda; Avcı, EminePurpose: Direct inguinal hernia is a protrusion of the visceral contents through the weakened part of the abdominal wall. The serum level of vitamin D has a positive correlation with muscle mass and functions. Therefore, decreased serum levels of vitamin D may facilitate direct inguinal hernia development. We aimed to compare the serum levels of vitamin D in patients with direct inguinal hernia and healthy individuals. Materials and Methods: Between April 2018 and October 2018, 30 patients with direct inguinal hernia (28 male, 2 female) and 30 healthy individuals within the control group (28 male, 2 female) were included in the study. Serum vitamin D levels of the participants and ultrasound findings of the patients were reviewed retrospectively. Results: The mean serum 25(OH)D level was 23.11±8.42 ng/mL in patients and 24.77±10.67 ng/mL in healthy individuals, respectively (p=0.77). Serum 25(OH)D level was decreased in 27 (90%) patients, and it was within normal limits in 3 (10%) patients. Serum 25(OH)D level was decreased in 21 (70%) healthy individuals, and it was normal in 9 (30%) healthy individuals within the control group (p=0.11). Conclusion: The results obtained from this study revealed that the patients with direct inguinal hernia had lower serum vitamin D levels than healthy individuals. However, there was no statistically significant difference in serum vitamin D levels between patients with inguinal hernia and control group. Therefore, our hypothesis if low serum 25(OH)D levels caused direct inguinal hernia could not be proved. A larger sample group is needed for further investigation.Öğe Estrogen receptor positive, progesterone receptor negative, leiomyoma of the areola of a male patient(Dermatology Online Journal, 2018) Yüksel, Mehmet Eren; Tamer, Funda; Bozlak, NurtenLeiomyoma of the nipple and areola is a rare subtype of genital leiomyoma. The etiology of the tumor is not well understood. However, sex hormones like estrogen and progesterone have been implicated in the tumorigenesis. Hereby, we report a 47-year-old man with an estrogen receptor positive, progesterone receptor negative, leiomyoma of the areola. © 2018, Dermatology Online Journal. All rights reserved.Öğe Generalised lichenoid drug eruption accompanied by hand-foot syndrome due to capecitabine(Medknow Publications & Media Pvt Ltd, 2018) Tamer, Funda; Yüksel, Mehmet Eren[Abstract Not Available]Öğe Is mean platelet volume an inflammatory marker in acne patients treated with isotretinoin?(Dermatovenerological Soc Slovenia, 2019) Tamer, Funda; Yüksel, Mehmet Eren; Avcı, EmineIntroduction: Isotretinoin is a commonly used systemic retinoid for treating acne. However, isotretinoin may lead to elevated serum levels of triglycerides and cholesterol, and it may affect liver function tests. Moreover, the effect of isotretinoin on hematological parameters remains controversial. This study examines changes in the blood chemistry panel, hematological parameters, and inflammation biomarkers of patients diagnosed with acne and treated with isotretinoin. Methods: The study included 70 patients (59 females and 11 males, between ages 18 and 37) with moderate to severe acne vulgaris treated with isotretinoin. The medical records and laboratory findings of the participants were reviewed retrospectively between March 2017 and September 2018. All the patients whose necessary laboratory test results could be obtained from the collected data were included in the study. Results: Serum total cholesterol, HDL, LDL, triglyceride, mean corpuscular hemoglobin levels, and platelet/lymphocyte ratio increased, whereas white blood cell count and mean platelet volume (p = 0.036) decreased after isotretinoin treatment. Conclusions: The results of this study revealed that mean platelet volume decreased significantly 3 months after the initiation of isotretinoin treatment. Therefore, we suggest considering mean platelet volume as an inflammatory marker in patients with acne treated with isotretinoin. However, this research should be replicated under more randomized conditions in a prospective study to reach a definitive conclusion.Öğe Phenol Is prohibited for the treatment of pilonidal disease in Germany, why not in the United States?(NLM (Medline), 2019) Yüksel, Mehmet Eren; Tamer, Funda–We have read “The American Society of Colon and Rectal Surgeons’ Clinical Practice Guidelines for the Management of Pilonidal Disease” with great interest.1 Johnson et al1 stated that phenol application was an effective treatment that might result in rapid and durable healing in patients who had acute or chronic pilonidal disease without abscess. Using phenol in the treatment of pilonidal disease was strongly recommended based on moderate-quality evidence, grade 1B. Grade 1B recommendation necessitated that the benefit of phenol application clearly outweighed risk and burdens or vice versa. Moreover, grade 1B recommendation gave permission to physicians to apply phenol to most patients in most circumstances without reservation. However, Iesalnieks et al,2 who published a German national guideline on the management of pilonidal disease in 2016, reported that the treatment of pilonidal disease with phenol was prohibited by German health authorities (Bundesgesundheitsamt) in 1991.3 Moreover, Bruce et al3 reported that phenol poisoning could occur by skin absorption, vapor inhalation, or ingestion, and, regardless of route of exposure, acute toxicity could result in muscle weakness, convulsion, and coma.Öğe Pre-treatment vitamin B12, folate, ferritin, and vitamin D serum levels in patients with warts: A retrospective study(Medicinska Naklada Zagreb, 2020) Tamer, Funda; Yüksel, Mehmet Eren; Karaba?, YavuzAim To compare the serum levels of 25-hydroxyVitamin D, ferritin, folate, vitamin B12, zinc, and thyroid stimulating hormone between patients with warts and healthy individuals. Methods This retrospective study enrolled 40 patients with warts and 40 healthy individuals treated at the Ufuk University Hospital, Ankara, between July and December 2017. Serum levels of 25-hydroxyVitamin D, ferritin, folate, vitamin B12, zinc, and thyroid stimulating hormone status were evaluated retrospectively. Results Participants with and without warts had similar mean serum 25-hydroxyVitamin D, ferritin, folate, zinc, and thyroid stimulating hormone levels. However, patients with warts had significantly lower mean serum vitamin B12 level (P = 0.010). Patients with warts non-significantly more frequently had decreased serum levels of 25-hydroxyVitamin D, ferritin, and folate (P = 0.330, P = 0.200, P = 0.070, respectively). Conclusion Patients with warts may require evaluation of serum levels of vitamin B12, folate, ferritin, and Vitamin D.Öğe Serum ferritin and vitamin D levels should be evaluated in patients with diffuse hair loss prior to treatment(Termedia Publishing House Ltd., 2020) Tamer, Funda; Yüksel, Mehmet Eren; Karaba?, YavuzIntroduction: Various factors like physiological and emotional stress, drugs and nutritional deficiencies can result in hair loss. Results of laboratory tests examining the underlying aetiology of hair loss vary in patients. Aim: We aimed to compare the serum levels of ferritin, folate, vitamin B12, zinc, thyroid stimulating hormone and vitamin D in patients complaining of diffuse hair loss and in healthy individuals. Material and methods: Fifty-four patients with hair loss (47 females, 7 males) and 55 healthy individuals within the control group (47 females, 8 males) were included in this study. Serum levels of ferritin, folate, vitamin B12, zinc, thyroid stimulating hormone and 25-hydroxyvitamin D were evaluated in all participants retrospectively. Results: Serum concentrations of folate, vitamin B12, zinc and thyroid stimulating hormone were similar in the two groups. However, the mean serum ferritin and 25-hydroxyvitamin D levels were significantly lower in patients with hair loss than in healthy individuals. The mean serum ferritin levels of the patients and healthy individuals were 14.72 10.70 ng/ml and 25.30 14.41 ng/ml, respectively. The mean serum 25-hydroxyvitamin D levels of the patients and healthy individuals were 14.03 8.09 ng/ml and 17.01 8.59 ng/ml, respectively. Eleven (20.4%) patients had low serum ferritin levels, while 43 (79.6%) patients had low vitamin D levels. Conclusions: The results obtained from this study reveal that serum ferritin and 25-hydroxyvitamin D levels are generally low in patients complaining of hair loss. Therefore, serum ferritin and vitamin D levels should be evaluated and supplemented prior to treatment in all patients complaining of diffuse hair loss.Öğe Staphylococcus aureus is the most common bacterial agent of the skin flora of patients with seborrheic dermatitis(Dermatology Practical & Conceptual, 2018) Tamer, Funda; Yüksel, Mehmet Eren; Sarıfakıoğlu, Evren; Karabağ, YavuzBackground: Seborrheic dermatitis is an inflammatory skin disease that affects 1-3% of the general population. The Malassezia species has been implicated as the main causative agent; however, the bacterial flora of the skin may also play role in the etiopathogenesis. Therefore, we investigated the most common bacterial agent of the skin flora of patients with seborrheic dermatitis. Materials and methods: Fifty-one patients with seborrheic dermatitis and 50 healthy individuals are included in this study. Sterile cotton swabs were rubbed on the scalp of the participants for bacterial culture. Colonial morphology was identified with gram stain and catalase test. Results: Staphylococcus aureus was isolated from 25 (49%) patients with seborrheic dermatitis and 10 (20%) healthy individuals within the control group. Coagulase-negative staphylococci were isolated from 24 (47.1%) patients with seborrheic dermatitis and 17 (34%) healthy individuals within the control group. Diphtheroids were present in 2 (3.9%) patients and 1 (2%) subject within the control group. Gram-negative bacilli were present only in 1 (2%) patient. Hemolytic streptococci and bacilli were identified in 1 (2%) subject from each group. Colonization of coagulase-negative staphylococci, diphtheroids, gram-negative bacilli, hemolytic streptococci, and bacillus did not differ between patients and healthy controls. However, S. aureus colonization was significantly more common in patients with seborrheic dermatitis than in healthy controls. Conclusion: Within this study we revealed that S. aureus colonization was significantly higher among the patients. Therefore, we propose that, in addition to the Malassezia species, S. aureus may play a role in the etiopathogenesis of seborrheic dermatitis.
