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    A review on exopolysaccharide production by Lactobacillus acidophilus and their techno-functional applications in food and pharmaceutical industry
    (Innovative Scientific Information and Services Network, 2023) Dailin, Daniel Joe; Bing, Loo Yoo; Hanapi, Siti Zulaiha; Yenn, Tong Woei); Zailani, Siti Nazrah; Çamkerten, İlker; Sukmawati, Dalia; El Enshasy, Hesham Ali
    Bacterial exopolysaccharides (EPS) are renowned for their technical and functional applications in the food and pharmaceutical industry.EPS retrieved from Lactobacillus sp.is one of the bacterial groups that have garnered a great deal of attention by showing its unique behaviors by expressing their ability to promote health benefits. The EPS from Lactobacillus acidophilus finds application in many areas like food, pharmaceuticals, bioremediation, cosmetics, and others. As EPS produced by Lactobacilli has conferred a range of local and systemic health benefits on the host, synthesis of these metabolites through fermentation should be emphasized. An optimal and cost-effective fermentation process by understanding the parameters and conditions is crucial in optimising the EPS yields. This review gives an overview of the biosynthesis of the EPS and the factors influencing the production of the EPS. Finally, techno-functional applications in food and pharmaceutical products associated with EPS are discussed.
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    Öğe
    Antidiabetic effects and enzymatic antioxidant activity of chicken drumstick mushroom (Coprinus comatus) extract in diabetic rats model
    (Journal of Pure and Applied Microbiology, 2022) Ratnaningtyas, Nuniek Ina; Husen, Fajar; Sukmawati, Dalia; Wibowo, Eko Setio; Hikam, Arif Rahman; Aksoy, Adil
    Coprinus comatus (O.F. Mull.) Pers. is a medicinal and edible mushroom containing bioactive compounds known as antidiabetic and antioxidant agents. The pancreatic ?-cells were sensitive to reactive oxygen species (ROS) attacks, which can cause necrosis and disrupt insulin production. Therefore, this research aimed to evaluate the C. comatus ethyl acetate extract for antidiabetic and antioxidant to decrease fasting blood glucose, dipeptidyl peptidase-4 enzyme (DPP-4) levels, and increase glutathione peroxidase (GPx). Subsequently, 24 male Wistar rats were divided into six groups, namely 2-5 streptozotocin (STZ)-induced 45 mg/kg, 1/HC (without any treatment), 2/NC (negative control), 3/PC (administered metformin 45 mg/kg Body weight (BW), 4-6 (T1: administered 250 mg, T2: administered 500 mg, and T3: administered 750 mg/kg BW extract). The parameters were analyzed using ANOVA, followed by Duncan’s multiple range test. According to the results, the extract significantly decreased DPP-4 levels, blood glucose and increased GPx (p ? 0.05). The 500 mg extract effectively reduced blood glucose levels and DPP-4 enzyme as well as increased levels of GPx.