Yazar "Stauber, Roland H." seçeneğine göre listele

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    A Review for Uncovering the “Protein-Nanoparticle Alliance”: Implications of the Protein Corona for Biomedical Applications
    (Multidisciplinary Digital Publishing Institute (MDPI), 2024) Önal Acet, Burcu; Gül, Désirée; Stauber, Roland H.; Odabaşı, Mehmet; Acet, Ömür
    Understanding both the physicochemical and biological interactions of nanoparticles is mandatory for the biomedical application of nanomaterials. By binding proteins, nanoparticles acquire new surface identities in biological fluids, the protein corona. Various studies have revealed the dynamic structure and nano–bio interactions of the protein corona. The binding of proteins not only imparts new surface identities to nanoparticles in biological fluids but also significantly influences their bioactivity, stability, and targeting specificity. Interestingly, recent endeavors have been undertaken to harness the potential of the protein corona instead of evading its presence. Exploitation of this ‘protein–nanoparticle alliance’ has significant potential to change the field of nanomedicine. Here, we present a thorough examination of the latest research on protein corona, encompassing its formation, dynamics, recent developments, and diverse bioapplications. Furthermore, we also aim to explore the interactions at the nano–bio interface, paving the way for innovative strategies to advance the application potential of the protein corona. By addressing challenges and promises in controlling protein corona formation, this review provides insights into the evolving landscape of the ‘protein–nanoparticle alliance’ and highlights emerging.
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    Revolution in Cancer Treatment: How Are Intelligently Designed Nanostructures Changing the Game
    (Multidisciplinary Digital Publishing Institute (MDPI), 2024) Gül, Désirée; Önal Acet, Burcu; Lu, Qiang; Stauber, Roland H.; Odabaşı, Mehmet
    Nanoparticles (NPs) are extremely important tools to overcome the limitations imposed by therapeutic agents and effectively overcome biological barriers. Smart designed/tuned nanostructures can be extremely effective for cancer treatment. The selection and design of nanostructures and the adjustment of size and surface properties are extremely important, especially for some precision treatments and drug delivery (DD). By designing specific methods, an important era can be opened in the biomedical field for personalized and precise treatment. Here, we focus on advances in the selection and design of nanostructures, as well as on how the structure and shape, size, charge, and surface properties of nanostructures in biological fluids (BFs) can be affected. We discussed the applications of specialized nanostructures in the therapy of head and neck cancer (HNC), which is a difficult and aggressive type of cancer to treat, to give an impetus for novel treatment approaches in this field. We also comprehensively touched on the shortcomings, current trends, and future perspectives when using nanostructures in the treatment of cancer.
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    Synthesis, characterization, and exosomal corona formation of self-assembled dipeptide nanomaterials
    (Nature Research, 2025) Önal Acet, Burcu; Acet, Ömür; Wandrey, Madita; Stauber, Roland H.; Gül, Désirée; Odabaşı, Mehmet
    Exosomes (Exos), also known as small extracellular vesicles, are naturally occurring nanoparticles (NPs), which are characterized by their nanometer size and negative charged in physiological environments. While it is widely accepted that proteins and biological compounds adhere to different nanomaterials (NMs), forming an outer layer known as the biomolecule corona (BC), the detailed understanding of factors contributing to BC formation as well as of its biological effects remains limited. Studies have shown that BC formation can affect the physicochemical properties of synthetic and natural NPs once contacting biological fluids. Here, we present a study investigating the novel concept of exosomal corona formation, which in contrast to the well-documented BC mainly consists of Exos/exosomal components. For this purpose, peptide-based Fmoc-Lysine (Fmoc-Lys) NMs were synthesized and characterized, and interaction studies with (cancer) cell-derived Exos were performed. Measurements of size, zeta potential, and colloidal stability indicate exosomal corona formation. Furthermore, cell viability experiments showed that the Exo-NM interaction resulted in reduced nanotoxicity profile indicating practical relevance for biological applications of these NMs. In summary, here we provide first evidence supporting the concept of exosomal corona formation around NMs that should become part of evaluating interactions at nano-bio-interfaces.