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Öğe Aza-BODIPY based fluorescent and colorimetric sensors and probes(Bentham Science Publishers Ltd., 2023) Sonkaya, Ömer; Soylukan, Caner; Algı, Melek Pamuk; Algı, FatihAza-boron-dipyrromethenes (Aza-BODIPYs) represent an important class of chromophores absorbing and emitting in the near-infrared (NIR) region. They have unique optical and electronic features and higher physiological and photo stability than other NIR dyes. Especially after the development of facile synthetic routes, Aza-BODIPYs have become indispensable fluors that can find various applications ranging from chemosensors, bioimaging, phototherapy, solar energy materials, photocatalysis, photon upconversion, lasers, and optoelectronics. Herein, we review Aza-BODIPY based fluorescent and colorimetric chemosensors. We show the potential and untapped toolbox of Aza-BODIPY based fluorescent and colorimetric chemosensors. Hence, we divide the fluorescent and colorimetric chemosensors and probes into five sections according to the target analytes. The first section begins with the chemosensors developed for pH. Next, we discuss Aza-BODIPY based ion sensors including, metal ions and anions. Finally, we present the chemosensors and probes concerning reactive oxygen (ROS) and nitrogen species (RNS) along with biologically relevant species in the last two sections. We believe that Aza-BODIPYs are still in their infancy, and they have a promising future for translation from the bench to real biomedical and materials science applications. After two decades of intensive research, it seems that there are many more to come in this already fertile field. Overall, we hope that future work will further expand the applications of Aza-BODIPY in many areas.Öğe Azabodıpy ve indirgenmiş grafen oksit tabanlı yeni bir nanoteranostik: tasarım ve sentez(Aksaray Üniversitesi Fen Bilimleri Enstitüsü, 2020) Soylukan, Caner; Algı, FatihKanser, hücrelerin kontrolsüz çoğalmasıyla oluşan ve klinik görünümü, tedavisi ve yaklaşımı birbirinden farklı olan bir hastalık grubudur. Kanser tedavi yöntemleri; cerrahi, kemoterapi ve radyoterapidir. Son yıllarda geliştirilmiş tedavi yaklaşımları olan fotodinamik terapi ve fototermal terapi oldukça dikkat çekmektedir. Fotodinamik terapi kanserli veya kötü huylu olmayan bazı hastalıkların tedavisinde yaygın olarak kullanılmaktadır. Bu tedavi yöntemi, hastalıklı hücreleri seçici ve etkili bir şekilde yok eden bir fotoduyarlaştırıcı ve ona uygun bir ışık kaynağının, tercihen yakın kızıl ötesi bölgede (650-800 nm), kullanılması ile gerçekleştirilir. Son yıllarda geliştirilmiş bir çok fotoduyarlaştırıcı olmasına rağmen, klinik uygulamalar için onaylanmış terapi ajanı sayısı oldukça azdır. Fototermal Terapi (FTT), soğurulan yakın kızıl ötesi (NIR) ışığın ısı enerjisine dönüşmesi esasına dayanan bir tedavi yöntemidir. FTT son dönemde oldukça ilgi çekmektedir. Bu tezde indirgenmiş grafen oksitle kombine edilmiş AzaBODIPY temelli yeni bir nanoteranostik ajanın, AzaBODIPY@NrGO, sentezi ve karakterizasyonu yapılmıştır. Bu yeni malzemenin fotodinamik terapi ve fototermal terapi yapabileceği in vitro deneylerle gösterilmiş olup kanser tedavisinde umut vaat ettiği ortaya konmuştur.Öğe BODIPY and 2,3-dihydrophthalazine-1,4-dione conjugates as heavy atom-free chemiluminogenic photosensitizers(American Chemical Society, 2021) Değirmenci, Aysun; Sonkaya, Ömer; Soylukan, Caner; Karaduman, Tuğçe; Algı, FatihWe disclose an interesting concept for developing heavy atom-free chemiluminogenic photosensitizers. To accomplish this, conjugates 2 and 3, which are composed of boron-dipyrromethene (BODIPY) and 2,3-dihydrophthalazine-1,4-dione units, are investigated. 2 and 3 are compared in terms of their photophysical properties, chemiluminescence responses, and singlet oxygen production. Strikingly, the results indicate that decoration of BODIPY with the 2,3-dihydrophthalazine-1,4-dione scaffold boosts the singlet oxygen generation. Furthermore, treatment of epidermoid laryngeal carcinoma Hep-2 (Hep-2) cells with conjugates 2 and 3 results in efficient cellular internalization which ensures live- cell imaging of Hep-2 cells. Finally, it is noteworthy that in vitro cytotoxicity assays reveal that both 2 and 3 induce cytotoxicity when illuminated with red light. Thus, 2 and 3 represent heavy atom-free chemiluminogenic photosensitizers.Öğe Chemical composition and nutrient profiles of nine red macroalgae species(BioMed Central Ltd, 2024) Yücetepe, Aysun; Kırkın, Celale; Ayar, Eda Nur; Soylukan, Caner; Dikici, Emrah; Özçelik, Beraat; Okudan, Emine ŞükranNine red macroalgae (Amphiroa rigida, Gracilaria bursa-pastoris, Gracilaria gracilis, Grateloupia torture, Jania rubens, Laurencia obtusa, Laurencia pyramidalis, Liagora viscida, and Pterocladiella capillaries) were collected from coastal waters of Türkiye, and their proximate, fatty acid, soluble carbohydrate, and mineral profiles were investigated in the present study. According to the results, the crude protein content of the samples was between 4% and 23.8%, and four of the samples (G. turuturu, L. obtusa, L. pyramidalis, and P. capillacea) contained more than 10% protein. The crude lipid content of all the samples was below 1.6%, and the total carbohydrate content was between 38.3% and 76.9%. The macroalgae samples were generally richer in saturated fatty acids, palmitic acid being the most abundant, whereas G. gracilis had the highest content of unsaturated fatty acids (55.8%). All samples exhibited high contents of myo-inositol or glucose. Also, the samples generally had a good composition of minerals. Still, the heavy metal (i.e., Pb and Cd) content of Gracilaria gracilis was higher (59.6 µg/kg, P < 0.05) than those of the other algae samples. This study provides valuable insight into the chemical composition and fatty acid, mineral, and soluble carbohydrate profiles of Amphiroa rigida, Gracilaria bursa-pastoris, Gracilaria gracilis, Grateloupia turuturu, Jania rubens, Laurencia obtusa, Laurencia pyramidalis, Liagora viscida, and Pterocladiella capillacea from Türkiye.Öğe Evaluation of biological (feed, water), seasonal, and geological factors affecting the heavy metal content of raw milk(Academic Press Inc., 2023) Özbay, Sena; Dikici, Emrah; Soylukan, CanerIn volcanic regions worldwide, soil and water can be contaminated with heavy metals. Aksaray province is also an important region in this respect. Because this city is located around Hasandağı, an extinct volcanic mountain. In addition, the city is also an important dairy center. In this regard, evaluating the milk produced in Aksaray in terms of heavy metal contamination and studying the effect of feed and water on this contamination is essential. For this purpose, feed, water, and milk samples from 7 milk producers determined in Aksaray province were collected in 3 different seasons within six months. The presence and levels of arsenic (As), aluminum (Al), nickel (Ni), cadmium (Cd), and lead (Pb) were determined by ICP-MS analysis of the 126 samples obtained. The study found varying levels of heavy metals in feed, water, and milk. It was also observed that milk contained considerably lower quantities of metals and metalloids than feed and water. In addition, it has been determined that the distance to Hasandağı does not affect the trace element levels in water, milk, and feed, but there is a significant relationship between seasonal changes and trace elements in the samples. According to the analysis results, the highest level is the feed's aluminum level (298,290.1 µg/kg). However, the aluminum level in milk remained well below this level (96.15 µg/kg). It was determined that the cadmium level in milk reached the highest level in spring (average 0.06 µg/kg), whereas lead levels reached the highest level in summer (average 2.14 µg/kg). On the other hand, the arsenic level showed a relatively small change according to the distance to the volcanic region. The average arsenic level in milk from regions near the volcanic area was measured as 1.01 µg/kg. In remote areas, this amount was measured as 0.94 µg/kg, Furthermore, the highest heavy metal level in the milk was 182.08 µg/kg for nickel during the summer months in the study.Öğe Fabrication of PAMP/Au and GO/PAMP/Au nanosensors for electrochemical detection of paracetamol in pharmaceutical preparations(Springer, 2021) Bilici, Ali; Denizhan, Nuray; Emre, Deniz; Soylukan, Caner; Algı, Fatih; Yılmaz, SelehattinThis paper reports on the modification of Pencil Graphite Electrode (PGE) surface with the poly(2-amino-4-methylphenol)/gold (PAMP/Au) and graphene oxide/poly(2-amino-4-methylphenol)/gold (GO/PAMP/Au) nanocomposites, in two steps. The first step is based on the one-pot preparation of composites by template-free chemical oxidation process. In the second step, composites are deposited at PGE surface by electro-oxidation process. Both nanocomposites and modified PGE surfaces are characterized by X-Ray Diffraction method (XRD), Scanning Electron Microscopy (SEM), EDAX, and CV analyses. The electrochemical performances of modified electrodes (abbreviated as PAMP/Au-PGE and GO/PAMP/Au-PGE) were investigated. The limit of detection values for PGE, PAMP/Au-PGE, and GO/PAMP/Au-PGE were found to be 2.74 × 10–6, 5.29 × 10–7, and 2.91 × 10–8 mol/dm3, respectively. The limit of quantification values were determined as 9.14 × 10–6, 1.76 × 10–6, and 9.69 × 10–8 mol/dm3 for PGE, PAMP/Au-PGE, and GO/PAMP/Au-PGE, respectively.Öğe Nanomaterial surface modification toolkit: Principles, components, recipes, and applications(Elsevier B.V., 2023) Kaymaz, Sümeyra Vural; Nobar, Hediyeh Malekzadsani; Sarıgül, Hasan; Soylukan, Caner; Akyüz, Lalehan; Yüce, MeralSurface-functionalized nanostructures are at the forefront of biotechnology, providing new opportunities for biosensors, drug delivery, therapy, and bioimaging applications. The modification of nanostructures significantly impacts the performance and success of various applications by enabling selective and precise targeting. This review elucidates widely practiced surface modification strategies, including click chemistry, cross-coupling, silanization, aldehyde linkers, active ester chemistry, maleimide chemistry, epoxy linkers, and other protein and DNA-based methodologies. We also delve into the application-focused landscape of the nano-bio interface, emphasizing four key domains: therapeutics, biosensing, environmental monitoring, and point-of-care technologies, by highlighting prominent studies. The insights presented herein pave the way for further innovations at the intersection of nanotechnology and biotechnology, providing a useful handbook for beginners and professionals. The review draws on various sources, including the latest research articles (2018-2023), to provide a comprehensive overview of the field.
