Yazar "Soylu, Korhan" seçeneğine göre listele
Listeleniyor 1 - 7 / 7
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Evaluation of inhomogeneities of repolarization in patients with psoriasis vulgaris(Termedia Publishing House Ltd, 2016) Soylu, Korhan; İnci, Sinan; Aksan, Gökhan; Nar, Gökay; Pancar Yüksel, Esra; Öcal, Hande Serra; Çapraz, Mustafa; Yüksel, Serkan; Şahin, MahmutIntroduction: The arrhythmia potential has not been investigated adequately in psoriatic patients. In this study, we assessed the ventricular repolarization dispersion, using the Tp-e interval and the Tp-e/QT ratio, and investigated the association with inflammation. Material and methods: Seventy-one psoriasis vulgaris patients and 70 ageand gender-matched healthy individuals were enrolled in the study. The severity of the disease was calculated using Psoriasis Area and Severity Index scoring. The QTd was defined as the difference between the maximum and minimum QT intervals. The Tp-e interval was defined as the interval from the peak of the T wave to the end of the T wave. The Tp-e interval was corrected for heart rate. The Tp-e/QT ratio was calculated using these measurements. Results: There were no significant differences between the groups with respect to basal clinical and laboratory characteristics (p > 0.05). The Tp-e interval, the corrected Tp-e interval (cTp-e) and the Tp-e/QT ratio were also significantly higher in psoriasis patients compared to the control group (78.5 ±8.0 ms vs. 71.4 ±7.6 ms, p < 0.001, 86.3 ±13.2 ms vs. 77.6 ±9.0 ms, p < 0.001 and 0.21 ±0.02 vs. 0.19 ±0.02, p < 0.001 respectively). A significant correlation was detected between the cTp-e time and the Tp-e/QT ratio and the PASI score in the group of psoriatic patients (r = 0.51, p < 0.001; r = 0.59, p < 0.001, respectively). Conclusions: In our study, we detected a significant increase in the Tp-e interval and the Tp-e/QT ratio in patients with psoriasis vulgaris. The Tp-e interval and the Tp-e/QT ratio may be predictors for ventricular arrhythmias in patients with psoriasis vulgaris. © 2016 Termedia & Banach.Öğe Exercise-induced repolarization changes in patients with isolated myocardial bridging(International Scientific Literature, 2015) Aksan, Gökhan; Nar, Gökay; İnci, Sinan; Yanık, Ahmet; Kılıçkesmez, Kadriye Orta; Aksoy, Olcay; Soylu, KorhanBackground: Although myocardial bridging (MB) is defined as an angiographic phenomenon with a benign course, it has also been associated with adverse cardiovascular events. The effects of exercise on myocardial repolarization in patients with MB were tested in this study, with Tp-e and Tp-e/QT repolarization indexes. Material/Methods: A total of 50 patients in whom isolated MB was diagnosed at coronary angiography (CAG) (Group I) and 48 patients with normal CAG results (Group II) were included in this study. The participants underwent treadmill exercise stress testing according to the Bruce protocol. QT dispersion (QTd) was defined as the minimum QT interval subtracted from the maximum. The Tp-e interval was defined as the difference between the QT and the QT peak time period. QTd and Tp-e intervals were calculated for all patients before and after exercise testing and differences between groups were compared. Results: At peak exercise, QTd and cQTd showed a significant increase in comparison to baseline values in the group of patients with myocardial bridges. Significant increases were also found with exercise in the Tp-e, cTp-e durations and Tp-e/QT ratio of the MB patient group in comparison to the baseline values. On the other hand, significant differences in QTd, cQTd, Tp-e, cTp-e intervals, and Tp-e/QT ratio during peak exercise in comparison with baseline values were not detected in the control group (p>0.05). Conclusions: Significant increases in QTd, cQTd, Tp-e and cTp-e intervals and Tp-e/QT ratio were detected in the MB patients during exercise testing.Öğe Galectin-3 as a novel biomarker for the diagnosis of essential hypertension with left ventricular hypertrophy(Ondokuz Mayis Universitesi, 2016) Nar, Gökay; Aksan, Gökhan; Görgülü, Özkan; İnci, Sinan; Soylu, Korhan; Özdemir, Metin; Nar, Rukiye; Yüksel, SerkanGalectin-3 (Gal-3) is a carbohydrate-binding protein that has important regulatory roles in inflammation, immunity and cancer. The aim of this study was to investigate the relationship of Gal-3 level with left ventricular hypertrophy (LVH) related to hypertension (HT). Thirty seven patients (Group I) with newly diagnosed hypertension (HT) and left ventricular hypertrophy (LVH) were included in the study. Thirty eight patients with newly diagnosed hypertension without LVH (Group II) and 38 normotensive healthy volunteers (Group III) were included in the study as control group. Transthoracic echocardiography was performed and Gal-3 was measured in all patients. Although demographic characteristics of the groups were similar, systolic and diastolic blood pressure levels of Group I and Group II were significantly higher than Group III (p<0.001). Interventricular septum (IVS) thickness, posterior wall (PW) thickness and left ventricular mass index (LVMI) were also significantly increased in Group I compared to Group II and Group III. Serum Gal-3 levels in all three groups were seen to be different from each other (p<0.001). Increase of Gal-3 levels has a significant correlation with LVMI, IVS and PW thickness (p<0.001). We determined that Gal-3 levels, even at the newly diagnosed stage of HT, were increased. Moreover, we found strong correlation between Gal-3 levels and left ventricular muscle mass. These results may indicate that increased Gal-3 level is an important marker for target organ damage and high cardiovascular risk in patients with HT. © 2016 OMU.Öğe Is galectin-3 a biomarker, a player-or both-in the presence of coronary atherosclerosis?(BMJ Publishing Group, 2016) Aksan, Gökhan; Gedikli, Ömer; Keskin, Kudret; Nar, Gökay; İnci, Sinan; Yıldız, Süleyman Sezai; Kaplan, Özgür; Soylu, KorhanAtherosclerosis is a complex process mediated by leukocytes, macrophages and various inflammatory markers. Galectin-3 is secreted by activated macrophages and is involved in cardiac fibrosis, cardiac remodeling, and inflammation. The present study aimed to determine the relationship between the presence and severity of coronary artery disease (CAD) and serum galectin-3 levels. The study included 82 patients with CAD confirmed via coronary angiography and 82 healthy participants as control group. Angiographic CAD was defined as ?50% luminal diameter stenosis of at least one major epicardial coronary artery. The severity of CAD was determined by the Gensini score; and the serum galectin-3 levels were measured via ELISA. Serum galectin-3 levels were significantly higher in the patient group with CAD than in the control group (12.96±4.92 vs 5.52±1.9ng/mL, p<0.001). In the correlation analysis, serum galectin-3 showed significant correlation with the Gensini score (r=0.715, p<0.001), number of diseased vessels (r=0.752, p<0.001) and serum hs-CRP level (r=0.607, p<0.001). In addition, multivariate logistic regression analysis showed that the serum galectin-3 levels were significant and independent predictors of the presence of angiographic CAD (OR=3.933, 95% CI 2.395 to 6.457; p<0.001). In the present study, the serum galectin-3 levels were higher in the patients with CAD than in healthy controls. Also, serum galectin-3 levels showed a significant positive correlation with the severity of CAD. An increased serum galectin-3 level may be considered an important activator and a marker of the atherosclerotic inflammatory process in CAD.Öğe Ivabradine on aortic stiffness in patients with heart failure(Lippincott Williams and Wilkins, 2015) Nar, Gökay; İnci, Sinan; Aksan, Gökhan; Demirelli, Selami; Soylu, Korhan; Yüksel, Serkan; Gülel, Okan; İçli, AtillaAim: The aim of this study was to evaluate the effect of ivabradine treatment on aortic stiffness by measuring aortic elastic parameters in patients with heart failure (HF) receiving ivabradine treatment. Materials and Methods: The study included clinical patients who were diagnosed with HF (ejection fraction, <35%), had sinus rhythm and persistent symptoms despite full medical treatment. The study group consisted of patients with a heart rate greater than 70 beats per minute and the control group consisted of patients with a heart rate less than 70 beats per minute. Echocardiographic measurements were conducted and aortic strain, aortic distensibility, and aortic stiffness index were calculated. Results: By the end of the twelfth month, a decrease was observed in the left ventricular end-diastolic and end-systolic volumes, whereas ejection fraction was increased (P < 0.001). When aortic elastic parameters were evaluated between the 2 groups, therewas no significant difference regarding aortic strain, aortic distensibility, and aortic stiffness index at the time of enrollment and during the visit at 3 months. At the twelfth month visit, aortic strain (P < 0.001) and distensibility (P < 0.001) were significantly increased, whereas there was a significant decrease in the aortic stiffness index (P < 0.001). Conclusions: During the follow-up at 12 months, significant improvements were observed in the left ventricular functions and aortic elastic parameters along with decreased heart rate in patients with HF receiving ivabradine treatment. This outcome may indicate that ivabradine treatment may correct aortic stiffness and may reduce aortic stiffness after 1 year of follow-up.Öğe Neutrophil-to-lymphocyte ratio predicts coronary artery lesion complexity and mortality after non-ST-segment elevation acute coronary syndrome(Sociedade Portuguesa de Cardiologia, 2015) Soylu, Korhan; Gedikli, Ömer; Dağaşan, Göksel; Aydin, Ertan; Aksan, Gökhan; Nar, Gökay; İnci, Sinan; Yılmaz, ÖzcanObjective Inflammatory mechanisms are known to play an important role in coronary artery disease. The present study aimed to investigate the importance of the neutrophil-to-lymphocyte ratio (NLR) in terms of in-hospital mortality and its association with currently used risk scores in patients with non-ST-elevation acute coronary syndrome (NSTE-ACS). Methods Three hundred and seventeen patients with NSTE-ACS were included. The patients were divided into tertiles according to their NLR values (NLR <2.6, NLR=2.6-4.5, and NLR >4.5). Clinical and angiographic risk was evaluated by the SYNTAX and GRACE risk scores. Results The GRACE risk score was significantly higher in the group with high NLR values compared to those with moderate or low NLR (161.5±40.3, 130.5±32.3, and 123.9±34.3, respectively, p<0.001). Similarly, the SYNTAX score was significantly higher in the group with high NLR values (20.4±10.1, 15.5±10.5, and 13.4±7.8, respectively, p=0.003). Moreover, both GRACE (r=0.457, p<0.001) and SYNTAX scores (r=0.253, p=0.001) showed a significant positive correlation with NLR. Conclusion NLR has been found to be correlated with clinical and angiographic risk scores. Low NLR might be a good predictor for low in-hospital mortality and simple coronary anatomy in NSTE-ACS patients. © 2014 Sociedade Portuguesa de Cardiologia.Öğe P-wave dispersion and atrial electromechanical delay in patients with preeclampsia(S. Karger AG, 2015) İnci, Sinan; Nar, Gökay; Aksan, Gökhan; Sipahioğlu, Haydar; Soylu, Korhan; Doğan, AliObjectives: To investigate the duration of atrial electromechanical delay (EMD) and left atrial mechanical function in patients with preeclampsia. Materials and Methods: This study included 26 pregnant women with preeclampsia and 24 age-matched pregnant women without preeclampsia (control group). Atrial electromechanical coupling (PA) and intra-atrial and interatrial EMD were measured using tissue Doppler echocardiography. P-wave dispersion (PWD) was measured via 12-lead electrocardiography. All data were analyzed using SPSS v.15.0 for Windows (SPSS, Inc., Chicago, Ill., USA). Differences in continuous variables between groups were examined using a nonparametric Mann-Whitney U test. Correlation analysis was performed using Spearman's coefficient of correlation. Categorical values were compared using a ?2 test. Results: PA lateral and PA septal durations were significantly longer in the preeclampsia group than in the control group [74.6 ± 8.1 vs. 62.3 ± 5.3 ms (p < 0.001) and 59.7 ± 5.3 vs. 56.2 ± 4.9 ms (p = 0.005), respectively]. The duration of interatrial EMD and intra-atrial EMD in the preeclampsia group was significantly longer than in the control group [25.4 ± 4.6 vs. 13.2 ± 3.9 ms (p < 0.001) and 10.5 ± 1.9 vs. 7.1 ± 1.2 ms (p < 0.001), respectively]. PWD was significantly higher in patients with preeclampsia (43.1 ± 9.1 ms) than in the controls (37.6 ± 7.9 ms; p = 0.008). There was a significant correlation between PWD and interatrial EMD and intra-atrial EMD [r = 0.46 (p < 0.001) and r = 0.39 (p < 0.001), respectively]. Conclusion: The duration of atrial EMD and PWD was prolonged in patients with preeclampsia. © 2015 S. Karger AG, Basel.
