Yazar "Piel, Lindsay M. W." seçeneğine göre listele

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    Exploring Genetic Factors Associated with Moniezia spp. Tapeworm Resistance in Central Anatolian Merino Sheep via GWAS Approach
    (Multidisciplinary Digital Publishing Institute (MDPI), 2025) Arzık, Yunus; Kızılaslan, Mehmet; Behrem, Sedat; Piel, Lindsay M. W.; White, Stephen N.; Çınar, Mehmet Ulaş
    Gastrointestinal parasite (GIP) infections are a major challenge in pasture-based sheep farming, leading to both economic losses and animal welfare concerns. This study aimed to identify genetic factors that contribute to resistance against tapeworm (Moniezia spp.) infections in Central Anatolian Merino (CAM) sheep. We conducted genome-wide association studies (GWAS) on 226 CAM lambs, analyzing their genetic data in relation to Moniezia spp. egg burden. Thirteen significant genetic markers (SNPs) were identified. Two key immune-related genes, CD79A and MAP3K7, were linked to parasite resistance. CD79A is essential for B-cell activation and antibody production, while MAP3K7 regulates immune responses, particularly through NF-κB signaling. These findings highlight the potential for using genetic information to improve disease resistance in livestock breeding programs. Further research is needed to understand the role of these genes and to explore host–parasite interactions in more detail.
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    Genome-Wide Scan of Wool Production Traits in Akkaraman Sheep
    (MDPI, 2023) Arzık, Yunus; Kızılaslan, Mehmet; Behrem, Sedat; White, Stephen N.; Piel, Lindsay M. W.; Çınar, Mehmet Ulaş
    The objective of this study was to uncover the genetic background of wool quality, a production trait, by estimating genomic heritability and implementing GWAS in Akkaraman sheep. The wool characteristics measured included fibre diameter (FD) and staple length (SL) at the age of 8 months and yearling fibre diameter (YFD), yearling staple length (YSL) and yearling greasy fleece weight (YGFW) at 18 months of age. Animals were genotyped using the Axiom 50 K Ovine Genotyping Array. Maximum likelihood estimations of a linear mixed model (LMM) were used to estimate genomic heritability, where GWAS was conducted following a score test of each trait. Genomic heritability estimates for the traits ranged between 0.22 and 0.63, indicating that phenotypes have a moderate range of heritability. One genome- and six chromosome-wide significant SNPs were associated with the wool traits in Akkaraman lambs. Accordingly, TRIM2, MND1, TLR2, RNF175, CEP290, TMTC3, RERE, SLC45A1, SOX2, MORN1, SKI, FAAP20, PRKCZ, GABRD, CFAP74, CALML6 and TMEM52 genes as well as nine uncharacterized regions (LOC101118971, LOC105609137, LOC105603067, LOC101122892, LOC106991694, LOC106991467, LOC106991455, LOC105616534 and LOC105609719) were defined as plausible candidates. The findings of this study shed light on the genetics of wool quality and yield for the Akkaraman breed and suggests targets for breeders during systematic breeding programmes.