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    Alterations in blood parameters, DNA damage, oxidative stress and antioxidant enzymes and immune-related genes expression in Nile tilapia (Oreochromis niloticus) exposed to glyphosate-based herbicide
    (Elsevier, 2021) Acar, Ümit; İnanan, Burak Evren; Navruz, Fahriye Zemheri; Yılmaz, Sevdan
    In this study, effects of different concentrations (0, 5, 10, 20, 30, and 40 mg/L) of glyphosate-based herbicide (GBH) on Nile tilapia (Oreochromis nikticus) were investigated after a 14-day of exposure. After determination of LC50 value, effects of GBH on hematological and serum biochemical parameters in blood samples, DNA damage, lipid pemxidation and catalase activity in liver tissues, expression levels of antioxidant enzyme-related genes (SOD, CAT, GPx, and GST) and immune-related genes (TGF-beta, TGF-alpha and IL1-beta) were evaluated. The LC50 value has been found as 44.4 mg/L for GBH. GBH exposure at all concentrations caused alterations in blood parameters. GBH induced oxidative stress in liver and DNA damage in blood. Antioxidant enzyme-related genes were significantly up-regulated to suppress oxidative stress. On the other hand, the expression levels of immunerelated genes decreased in fish exposure to particularly >= 20 mg/L GBH.
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    Effects of essential oil derived from the bitter orange (Citrus aurantium) on growth performance, histology and gene expression levels in common carp juveniles (cyprinus carpio)
    (MDPI AG, 2021) Acar, Ümit; Kesbiç, Osman Sabri; Yılmaz, Sevda; İnanan, Burak Evren; Navruz, Fahriye Zemheri; Terzi, Funda; Fazio, Francesco; Parrino, Vincenzo
    The aim of this study was to detect effects of bitter orange (Citrus aurantium) essential oilcommonly called neroli oil (NO) (0, 0.25, 0.50, 1, and 1.5% referred to as NO0 NO0.25, NO0. 05, NO1 and NO1.5, respectively) on growth performance output and expression levels of some growth-related genes in the muscle tissue and some immune-related genes in the head kidney and pathologicadifferences in digestive system organs of common carp Cyprinus carpio. The NO0.25 group had a large improvement in growth efficiency at the end of the 60-day feeding cycle. Real-time PCR (Bio RAD, USA) system was used to detect variations in gene expression levels. Furthermore, NO supplementation of up to 0.25% in muscle tissue controlled the release of growth hormone (GH) and insulin-like growth factor I (IGF-I). Furthermore, in the NO0.25 treatment category, immune response gene levels TNF-?, IL-8 and IL-1ß increased in head kidney tissue. In the histological examination of the liver and intestine, there were significant differences between fish fed with N1 and N1.5 dietsThis study confirms that dietary supplementation of NO up to 0.25% can improve common carp growth efficiency and increase the expression of genes (GH and IGF-I) related to muscle growthTNF-?, IL-8 and IL-1ß genes related to immune status, and liver and intestine histological status ocommon carp.