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    Antibacterial, antioxidant, and angiotensin-I converting enzyme inhibition effects of margotia gummifera extracts rich in phenolic compounds
    (2022) Bouchekrit, Moufida; Laouer, Hocine; Çakmak, Yavuz Selim; Hajji, Mohamed; Boutellaa, Saber; Nasri, Moncef; Akkal, Salah
    Aromatic and medicinal plants have been used to substitute synthetic drugs with natural bioactive products. Objective: The current investigation was conducted to evaluate phenol and flavonoid contents, antibacterial, antioxidant, and anti-hypertensive potentials of three extracts of Margotia gummifera aerial parts. Methods: The antibacterial effect was assessed using the wells agar diffusion method against 11 strains. The antioxidant effect was evaluated using different methods, 2, 2-diphenyl-1-picrylhy-drazyl, total antioxidant capacity, ferric reducing ability power, cupric reducing antioxidant capaci-ty, and ?-carotene/linoleic acid bleaching assay. The anti-hypertensive activity was performed using hippuryl-histidyl-leucine substrates. Results: The highest yield, i.e., 19.801%, was obtained by the hydro-methanolic extract. However, ethyl acetate extract seemed to be rich in phenolic and flavonoid compounds compared to other ex-tracts, i.e., 822.14±69.10 mg GAE g-1 ext. and 117.28±1.80 mg RE g-1 ext., respectively. The high free radical scavenging activity was mentioned in ethyl acetate extract with IC50 of 48.820±1.25 ?g/ml. The same extract showed better antioxidant activity in all tested procedures. In antibacterial activity, the hydro-methanolic extract exhibited moderate effect against all tested bacteria except Salmonella enterica and Enterococcus faecalis which gave 18±2.0 and 16±1.0 mm of inhibition, whereas it seemed to be inactive towards two Gram-negative bacteria. Concerning anti-hyperten-sive activity, all extracts can inhibit the Angiotensin-I Converting Enzyme, but the potential effect was given by hydro-methanolic and aqueous extracts, 97.75% and 96.65%, respectively. Conclusion: It can be stated that the bioactive compounds of Margotia gummifera extracts had different biological activities, which confirm their therapeutic uses in traditional medicine.
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    Öğe
    Investigation of physicochemical and antioxidant properties of gelatinediblefilm mixed with blood orange (Citrus sinensis) peel extract
    (Elsevier Ltd., 2019) Jridi, Mourad; Boughriba, Soumaya; Abdelhedi, Ola; Nciri, Hend; Nasri, Rim; Kchaou, Hela; Kaya, Murat; Sebai, Hichem; Zouari, Nacim; Nasri, Moncef
    The present study aims at developing Grey triggerfish skin gelatin films containing phenolic extracts from blood orange (Citrus sinensis) peel, as an alternative for the existing synthetic packaging films. The effect of drying pretreatment on the phenolic compounds’ profile and antioxidant and antibacterial activities of the extracts was investigated. Physicochemical, thermal and mechanical properties of gelatin films incorporated with orange peel extract, at different concentrations and plasticized with glycerol were investigated. Films were also tested for their antioxidant capacity, monitored through the ?-carotene bleaching, DPPH radical-scavenging and reducing power activities. Results showed that the fresh orange peel extract (FOPE) was more effective against all bacteria tested and exhibited higher antioxidant effect than the thermally-dried orange peel extract (DOPE). In addition, the LC-ESI-MS analysis showed that the quinic acid was the major compound among the total poly-phenols followed by rutin, trans-ferulic acid, naringenin and 4,5-di-O-caffeoylquinate. After its addition, FOPE modified the mechanical and thermal properties of gelatin films, which showed more deformable texture than the control gelatin film. This effect may be caused by the interactions between phenolic compounds of the extract and gelatin chains, as assessed by the Fourier Transform infrared (FTIR) analysis. The FOPE-added films presented higher antioxidant properties than the control. Furthermore, release kinetics of FOPE through gelatin film showed controlled quasi-Fickian diffusion. The overall results emphasized the potential use of phenolic compounds from blood.