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  • Küçük Resim
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    Differences between Cu- and Fe–Cu nanoflowers in their interactions with fluorescent probes ANS and Fura-2 and proteins albumin and thrombin
    (Springer Science and Business Media Deutschland GmbH, 2022) Halets?BuiIn, Inessa; Dzmitruk, Volha; Abashkin, Viktar; Loznikova, Svetlana; Acet, Ömür; Önal, Burcu; Özdemir, Nalan; Bryszewska, Maria; Odabaşı, Mehmet; Shcharbin, Dzmitry
    Among nanomaterials, we can now distinguish a special class called nanoflowers (NFs). These new nanostructures have aroused the interest of scientists due to the topographic features of nanolayers, the special location which allows a higher surface-to-volume ratio compared to classical spherical nanoparticles, thereby significantly increasing the efficiency of surface reactions for nanoflowers. The main value of nanoflowers is their action as enzyme stabilizers. A protein stability is usually enhanced by immobilization on a nanoflower surface through charge affinity and covalent bonds. The possibility of their use in vivo in biocatalysis, biosensors and medicine has been also investigated. We now report on the synthesis of two different nanoflowers: Cu nanoflowers and Fe3+ attached Cu nanoflowers and their interaction with two fluorescent probes, anilino-1-naphthalenesulfonic acid (ANS) and Fura 2, and two proteins, human serum albumin (HSA) and thrombin. Nanoflowers did not bind ANS, but bind efficiently to Fura 2 and both proteins. Modification of Cu–NFs by Fe3+ leads to significant changes in their binding capacity to fluorescent probe Fura 2 and both proteins. Their ability to bind fluorescent probe Fura 2 increased eightfold, and their ability to bind HSA and thrombin increased five times. Regarding Fe3+–Cu–NFs, a difference in binding between HSA and thrombin was found that can be explained by their structural features. Our data indicate the possibility of using studied nanoflowers for sorption of fluorescent probes and proteins.
  • Küçük Resim
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    Hybrid metal-organic nanoflowers and their application in biotechnology and medicine
    (Elsevier, 2019) Shcharbin, Dzmitry; Halets-Buis, Inessa; Abashkin, Viktar; Dzmitruk, Volha; Loznikova, Svetlana; Acet, Ömür; Odabaşı, Mehmet
    Nanoflowers - new nanostructures - have aroused the interest of scientists due to the topographic features of nanolayers, the special location of which allows a higher surface-to-volume ratio compared to classic spherical nanoparticles, which significantly increases the efficiency of surface reactions for nanoflowers. The main purpose of these types of nanomaterials is their use as enzyme stabilizers. To facilitate the functioning of enzymes under different conditions, organic-inorganic hybrid nanomaterials have been developed, the name of which indicates that all components of inorganic nanoparticles are associated with organic materials. These nanoparticles have many promising applications in catalysis, as biosensors, and for drug delivery. Organic-inorganic hybrid nanoflowers have led to the development of a new branch of chemistry - the chemistry of hybrid nanomaterials - in which research is rapidly developing. Thus, studying organic-inorganic hybrid nanocrystals can lead to creative new solutions in the field of chemistry of enzyme systems and the rapid development of bionanomaterials and new biotechnology industries. Present review focuses on wide biomedical applications of nanoflowers including biocatalysis, detection of substances, electrochemical biosensors based on nanoflowers, photosensitizers, drug and gene carriers and detection of various diseases, photothermal and other treatments. It will be interesting for wide range of scientists focusing in topic of new kinds of nanoparticles.