Yazar "Kuzgun, Selen" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim
    Öğe
    Is there any association between osteoporotic vertebral fracture and vitamin K epoxide reductase complex subunit-1 polymorphism in Turkish society? A pilot study
    (Hospital Clinicas, Sao Paul, 2019) Özgen, Merih; Coşan, Didem Turgut; Doğaner, Fulya; Soyocak, Ahu; Armağan, Onur; Kuzgun, Selen; Aydoğan, Ayşe Merve; Güneş, Hasan Veysi; Değirmenci, İrfan; Mutlu, Fezan
    OBJECTIVE: In this study, the relationship between osteoporotic vertebral fractures and 9041 Guanine/Adenine and 3673 Guanine/Adenine polymorphisms related to the vitamin K epoxide reductase complex subunit-1 (VKORC1) gene in postmenopausal women with osteoporosis was investigated. METHOD: DNA was isolated from blood samples collected from 150 women with postmenopausal osteoporosis. Genotyping of the two polymorphic regions (9041 Guanine/Adenine and 3673 Guanine/Adenine) in VKORC1 was performed using polymerase chain reaction-restriction fragment length polymorphism analysis. The presence of radiographic fractures among the 150 patients was ascertained by using the Genant method. RESULT: At least one fracture was detected in 98 patients, and no fracture was observed in 52 patients on radiological images. We found no association between the 9041 Guanine/Adenine (p=0.283) and 3673 Guanine/Adenine (p=0.232) polymorphisms of the VKORC1 gene and the development of secondary postosteoporotic fractures in our study. CONCLUSION: There was no relationship between osteoporotic vertebral fracture and VKORC1 gene polymorphism in a postmenopausal Turkish population.
  • [ X ]
    Öğe
    The association between VKORC1 gene 9041G/A polymorphism and fracture in postmenopausal osteoporosis
    (Elsevier Science Bv, 2014) Turgut Coşan, Didem; Doğaner, Fulya; Özgen, Merih; Soyocak, Ahu; Armağan, Onur; Guneş, Hasan Veysi; Değirmenci, İrfan; Kuzgun, Selen; Mutlu, Fezan Sahin
    [Abstract Not Available]