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    Pathomorphological findings of Mortellaro disease in dairy cattle
    (Chartered Inst. of Building Services Engineers, 2021) Tunç, Arda Selin; Çağatay, Soner; Sağlam, Mehmet; Kutsal, Osman
    Mortellaro disease is an infection caused by mostly spirochete bacteria in dairy cows, sheep, and goats. The aim of the present study was to define to Mortellaro disease pathomorphologically and immunohistochemically and investigate whether cell-cell adhesion connections are lost in cell proliferation. Tissue samples were collected from underfoots of Holstein (n: 6) and Swiss Brown (n: 15) dairy cattle. The sections were stained with hematoxylin-eosin (H&E) and Warthin-Starry (WS) for isolation of spirochetes histopathologically and with P-catenin and PCNA primary antibodies immunohistochemically. Histopathologically, number of the cells in the stratum spinosum layer increased excessively, and it gave finger-like extensions to the dermis. Black stained spirochetes were detected among enlarged keratinocytes and inflammatory cells in WS staining. beta-catenin was strongly positive in the cell membranes of epithelial cells in all slides. PCNA also gave positive reaction moderately (n: 18) and strongly (n: 3) in nuclei of epithelial cells. It was observed that P-catenin cell-cell adhesion connections did not impair in the disease, so this is thought to positively affect the prognosis of the disease. The high expression of PCNA showed that the mitotic activity was high and explained the formation of wart-like. As a result, while the disease does not have a poor prognosis, the disease has a negative economic impact, and the economical results of this disease might be much greater than the treatment costs. It is still seen in our country and causes in loss of yield for the economy of country.
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    Primary bone tumors in dogs and cats: 98 cases
    (Veteriner Hekimler Derneği, 2024) Filikci, Kürşat; Sağlam, Mehmet; Kutsal, Osman; Tunc, Arda Selin
    The aim of this study is to contribute to the current literature by determining the distribution of bone tumors in dogs and cats by breed, age, gender and location. Bone tumors are more common in dogs than cats, and the most common primary bone tumor in both species is osteosarcoma. The biopsy and necropsy reports of the Ankara University, Faculty of Veterinary Medicine, Department of Pathology , were retrospectively studied examining for cases of primary bone tumors in dogs and cats. This study's period encompassed from 2001 through 2020 (20 years). A total of 98 bone tumors were detected 70 in dogs and 28 in cats. Of the cases in dogs, 13 (18.57%) were necropsy, while 57 (81.43%) were biopsy. Sex distribution of bone tumors is in female dogs (n:28, 40%) and in male dogs (n:38, 54.29%). Also, females (n:17, 60.7%) and males (n:11, 39.3%) were observed in cats. in dogs, although 57.14% (n=40) were purebreds and 31.43% (n=22) were mongrel breeds, in cats, 75% of them were mongrel (n=21) and 7.1% (n=2) were purebred. While locations of tumors in dogs were appendicular (65.71%, n=46), axial (30%, n=21), locations of tumors in cats were appendicular (50%, n=14), axial (39.29%, n=11) and both appendicular and axial (10.71%, n:3). While 13 benign (18.57%) and 57 malignant (81.43%) tumors were observed in dogs, 4 benign (14.29%) and 24 malignant (85.71%) tumors were observed in cats. The data were analyzed in the SPSS program and no significant relationship was detected between the data (P>0.05). This study would contribute and conduce the comparative oncology for dogs and cats.