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  • Küçük Resim
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    Carotid intima-media thickness and serum proinflammatory cytokine levels in rosacea patients without cardiovascular risk factors
    (Blackwell Publishing Inc., 2021) Ertekin, Sümeyre Seda; Koku Aksu, Ayse Esra; Koçyiğit, Abdurrahim; Güler, Eray Metin; Baykara Ulusan, Melis; Gürel, Mehmet Salih
    There is a growing body of evidence linking rosacea to various systemic disorders, even though data regarding the association between rosacea and cardiovascular diseases are presently controversial. We sought to investigate the potential association of rosacea with subclinical atherosclerosis and serum proinflammatory/proatherogenic markers. This study included 44 patients with rosacea and 44 age-matched and sex-matched healthy control subjects. Patients with traditional cardiovascular risk factors or a history of cardiovascular events were excluded. Demographic, clinical, and laboratory data, including serum interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and high-sensitivity C-reactive protein (hs-CRP) levels were assessed. Carotid intima-media thickness (CIMT) and carotid plaques were measured by carotid ultrasonography. Serum IL-1 beta (P < .001), IL-6 (P < .001), TNF-alpha (P < .001), and hs-CRP (P < .001) levels were significantly higher in the patient group compared with the control group. Mean CIMT values did not differ significantly between the patient group and control group (P > .05). Patients with moderate to severe rosacea had a significantly greater CIMT than those with mild rosacea (P = .047). Rosacea patients with eye involvement had a significantly greater CIMT than those without eye involvement (P = .008). There was no significant correlation between CIMT values and inflammation parameters. As conclusion, in the absence of other traditional cardiovascular risk factors, rosacea does not seem to affect mean CIMT value. However, specific subgroups such as patients with moderate to severe disease or with eye involvement are associated with increased subclinical atherosclerosis and may require additional attention for cardiovascular disease prevention.
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    Evaluation of quality of life in female patients with melasma
    (2020) Kara Polat, Asude; Ertekin, Sümeyre Seda; Göre Karaali, Müge; Koku Aksu, Ayse Esra; Gürel, Mehmet Salih
    Melasma is an acquired pigmentation disease occurs on the face and neck, sun-exposed areas. It significantly affects the quality of life of the patients. The objective of thisstudy was to evaluate the quality of life in patients with melasma. A prospective cross-sectional study was conducted on 49 female patients diagnosed with melasma betweenNovember 2016 and March 2017 in a tertiary referral hospital dermatology outpatient clinic. The patients were evaluated according to age, marital status, educationlevel, Fitzpatrick skin type, puberty age, the duration of disease, family history, medical comorbidities. Disease severity were measured with the melasma area and severityindex (MASI). The patients were evaluated according to quality of life scales: Turkish version of the melasma quality-of-life questionnaire (MelasQoL-TR), DermatologyLife Quality Index (DLQI), Turkish version of Skindex 16. The correlation between the severity of the disease and the qualities of life of the patients were evaluated.Fourty-nine female patients with the mean age of 36.8 ± 7.8 enrolled in the study. Fitzpatrick skin type III (49.6%) and IV (49.0%) were the most common skin phototypes.The mean disease duration was 56.7 ± 49.0 months. The mean MASI score was 16.3 ± 8.7. The mean MeLaSQoL-TR score, DLQI score and Skindex 16 score were 34.4± 13.0, 15.1 ± 7.6, 34,7 ± 16,9 respectively. Significant positive correlation was found between MASI score and MelasQoL-TR, DLQI and Skindex 16 scores (p ˂ 0.05).When the scores of emotion and function of Skindex 16 were evaluated separately, there was a significant positive correlation between MASI score and these scores (p ˂0.05). However no significant correlation was observed between MASI score and Skindex 16 symptom score (p ˃ 0.05). There was a significant correlation between thesethree different life quality scales. Age and education level were not significantly related with quality of life scales in our study. In this study, all scale scores were high inpatients with melasma, and were correlated with severity of the disease. Melasma has a significant emotional and functional impact on quality of life in female patients.