Yazar "Khawar, Khalid Mahmood" seçeneğine göre listele

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    Chitosan-based delivery systems for plants: A brief overview of recent advances and future directions
    (Elsevier B.V., 2020) Mujtaba, Muhammad; Khawar, Khalid Mahmood; Camara, Marcela Candido; Carvalho, Lucas Bragança; Fraceto, Leonardo Fernandes; Morsi, Rania E.; Elsabee, Maker Z.; Kaya, Murat; Labidi, Jalel; Ullah, Hidayat; Wang, Depeng
    Chitosan has been termed as the most well-known among biopolymers, receiving widespread attention from researchers in various fields mainly, agriculture, food, and health. Chitosan is a deacetylated derivative of chitin, mainly isolated from waste shells of the phylum Arthropoda after their consumption as food. Chitosan molecules can be easily modified for adsorption and slow release of plant growth regulators, herbicides, pesticides, and fertilizers, etc. Chitosan as a carrier and control release matrix that offers many benefits including; protection of biomolecules from harsh environmental conditions such as pH, light, temperatures and prolonged release of active ingredients from its matrix consequently protecting the plant's cells from the hazardous effects of burst release. In the current review, tends to discuss the recent advances in the area of chitosan application as a control release system. Also, future recommendations will be made in light of current advancements and major gaps
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    Current advancements in chitosan-based film production for food technology; A review
    (Elsevier Science Bv., 2019) Mujtaba, Muhammad; Morsi, Rania Elsayed; Kerch, Garry M.; Elsabee, Maher Zaki; Kaya, Murat; Labidi, Jalel; Khawar, Khalid Mahmood
    Chitosan is obtained from chitin, which could be considered to be the most abundant polymer after cellulose. Owing to these properties, chitosan alone or chitosan-based composite film production is attaining huge attention in terms of applications from researchers and industrialists coming from divergent fields. To enhance the biological (mainly antimicrobial and antioxidant) and physiological (mainly mechanical, thermal and barrier) attributes of the chitosan-based films, a vast medley of plant extracts and supporting polymers has been blended into chitosan films. Considering the up to date literature reports based on chitosan film production and applications, it can be stated that still, the research ratio is low in this field. Chitosan blend/composite films with specific properties (superhydrophobicity, excellent mechanical strength, acceptable barrier properties) can be produced only for specific applications in food technology. In the current review, we tried to summarize the advancements made in the last 5-7 years in the field of chitosan film technology for its application in the food industry.
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    Newly isolated sporopollenin microcages from Cedrus libani and Pinus nigra as carrier for Oxaliplatin; xCELLigence RTCA-based release assay
    (Springer, 2022) Mujtaba, Muhammad; Akyüz Yılmaz, Bahar; Cansaran Duman, Demet; Akyüz, Lalehan; Yangın, Sevcan; Kaya, Murat; Çeter, Talip; Khawar, Khalid Mahmood
    Sporopollenin-mediated control drug delivery has been studied extensively owing to its desirable physicochemical and biological properties. Herein, sporopollenin was successfully extracted from C. libani and P. nigra pollens followed by loading of a commonly known anticancer drug Oxaliplatin. Drug loading and physicochemical features were confirmed by using light microscopy, FT-IR, SEM and TGA. For the first-time, real-time cell analyzer system xCELLigence was employed to record the Oxaliplatin loaded sporopollenin-mediated cell death (CaCo-2 and Vero cells) in real time. Both the release assays confirmed the slow release of oxaliplatin from sporopollenin for around 40-45 h. The expression of MYC and FOXO-3 genes has been significantly increased in CaCo2 cell and decreased non-cancerous Vero cell confirming the fact that sporopollenin-mediated control release of oxaliplatin is promoting apoptosis cell death preventing the spread of negative effects on nearby healthy cells. All the results suggested that C. libani and P. nigra can be suitable candidates for the slow delivery of drugs.
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    Production of novel chia-mucilage nanocomposite films with starch nanocrystals; An inclusive biological and physicochemical perspective
    (Elsevier Ltd., 2019) Mujtaba, Muhammad; Koç, Behlül; Salaberria, Asier Martinez; İlk, Sedef; Duman, Demet Cansaran; Akyüz, Lalehan; Çakmak, Yavuz Selim; Kaya, Murat; Khawar, Khalid Mahmood; Labidi, Jalel; Boufi, Sami
    In the current study, chia mucilage composite films with starch nanocrystals (3% and 6%) were produced. The films were analyzed physicochemically (FT-IR, AFM, TGA, DSC), mechanically (Tensile strength and contact angle) and biologically (antimicrobial, antioxidant and cytotoxicity) properties. The incorporation of starch nanocrystals was confirmed through FT-IR spectra showing broad OH peak and CO stretching and shift in NH bending vibrations to the lower wave number. Starch nanocrystals enhanced (control 287.23?°C, film with 3% SNC 286.91?°C and film with 6% mucilage 289.41?°C) the thermal properties of the composite films. The Young Modulus of the film showed an increase after the incorporation of starch nanocrystals due to the strong interaction between mucilage and nanocrystals. On the other hand, the overall hydrophobicity of mucilage composite film decreased due to the hydrophilic nature of cornstarch nanocrystals. MTT assay for cell proliferation revealed significant inhibition of cancer cell (HepG2) lines and exhibits a very low inhibition of epithelial cell line (Vero). Starch nanocrystals enhanced the antibacterial and antioxidant (threefold increase compare to control) properties of mucilage composite films. Mucilage-SNC composite films could be a good therapeutic gain for control and directed drug delivery, food packaging, food coating.