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  • Küçük Resim
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    Exposure to a 0.9-GHz electromagnetic field on postnatal days 21–45 may trigger the renin-angiotensin system in male rat: a histological and biochemical study
    (Springer Science and Business Media B.V., 2025) İkinci Keleş, Ayşe; Kaya, Haydar; Keleş, Gökhan; Erol, Hüseyin Serkan; Mercantepe, Tolga; Odacı, Ersan
    The aim of this study was to examine the relationship between the renin-angiotensin system (RAS) and histological and biochemical changes occurring in the kidney tissue of male rats exposed to a 0.9 GHz electromagnetic field (EMF). Twelve male rats aged 21 days were randomly assigned to control (C-Gr) and EMF (EMF-Gr) groups. No procedure was performed on C-Gr, while the EMF-Gr rats were exposed to a 0.9 GHz EMF on postnatal days 21–45 (one hour a day for 25 days). Tissues were removed at the end of the experiment and evaluated using biochemical, and histopathological methods. Increased kidney tissue volume and weight and total body weight were determined in the group exposed to EMF. Lipid peroxidation, glutathione, catalase, and superoxide dismutase also increased in the kidney tissue of the EMF-Gr rats. Histopathological evaluation revealed cortical/medullary bleeding/obstruction and widespread fibrosis, dilatation, vacuolization, and degeneration in distal and proximal tubules, decreased and atypical parietal cells, and degeneration in epithelial cells. Additionally, dilated and degenerated glomeruli in the Malpighian body, Bowman’s membrane degeneration and degeneration in the vascular pole, podocyte, pedicel and mesangial cells were also observed. As a result of exposure to EMF, oxidative stress, tissue volume and weight increased, and histopathological changes caused the formation of a pathway that triggers RAS in kidney tissues. In conclusion, long-term exposure to 0.9 GHz EMF can activate the renin-angiotensin system in the rat kidney, and we think that such activation may be associated with structural, histopathological, and biochemical changes occurring in renal tissue.
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    Exposure to an Electromagnetic Field During Adolescence Can Cause Destruction and Pain in Bone Tissue and Cells While Also Triggering New Bone Formation
    (Springer International Publishing, 2025) İkinci Keleş, Ayşe; Kaya, Haydar; İkinci Keleş, Gökhan; Tümkaya, Levent
    The aim of this study was to investigate the effects of the application during adolescence of a 0.9 Gigahertz electromagnetic field (EMF) on rat femoral bone tissue and locomotor activity. Methods: Twenty-four male 21-day-old Sprague Dawley rats were randomly divided into control, sham and EMF-exposed groups (n = 8). The control group was not exposed to any treatment, while both the EMF and sham groups were subjected to the exposure system for 25 days, the EMF group receiving treatment for one hour each day. Only the EMF group received the 0.9 Gigahertz EMF. All groups were subjected to open-field testing to evaluate locomotor activity on postnatal day 46. The animals were sacrificed on postnatal day 47, and the right femoral bones were removed and subjected to histopathological and stereological analyses. Results: Pathological changes were detected in the femoral bones from the EMF group, including significant decreases in the width of the femoral bone wall, trabecular volume, and total bone area. Osteocyte and osteoblast numbers also decreased significantly, while osteoclast numbers exhibited a significant increase (p < 0.05). Megakaryocytic hyperplasia and intravascular thrombus were observed in the bone marrow. The open-field test results revealed a significant decrease in EMF group rat motor functions (p < 0.05). Conclusions: The study findings show that a 0.9 Gigahertz EMF applied in the adolescent period leads to changes in femoral bone and bone marrow. This effect causes pathological and structural changes in rat bone tissue, and these may restrict the animals’ motor activities by causing pain.