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    Denizli organize sanayi bölgesi atıksu arıtma tesisi mevcut prosesleri ve alternatiflerinin değerlendirmesi
    (Aksaray Üniversitesi Fen Bilimleri Enstitüsü, 2022) Ceylan, Ahmet; Şimşek, İsmail
    Endüstriyel faaliyetler ekonominin temel yapıtaşıdır. Endüstriyel faaliyetler gerçekleştirilirken birçok doğal kaynağa ihtiyaç duyulmaktadır. Su tüketilen bu kaynakların başında gelmektedir. Sınırlı miktarda bulunan su kaynaklarımızın korunması için endüstriyel faaliyetleri gerçekleştirirken kirliliği ortadan kaldırmak veya asgari düzeye indirmek gerekir. Bu kapsamda endüstriyel atıksular etkin bir şekilde arıtılmalı ve mümkün olan en üst seviyede tesislerde yeniden kullanıma katılmalıdır. Bu çalışmada Denizli Organize Sanayi Bölgesi'nde endüstriyel ve evsel nitelikli atıksu arıtım faaliyeti gösteren Merkezi Atıksu Arıtma Tesisinde yer alan proseslerin mevcut durumu değerlendirilerek, kirleticilerin gideriminde alternatif olabilecek proses ve temel işlemlerin verimleri hakkında bilgi verilmiştir. Tesis proseslerinin genel verimini ortaya koymak amacıyla üç farklı tarihte beş farklı noktadan alınan numunelerde KOİ, AKM, TP, TN ve Renk analizleri yapılmıştır. Analiz sonuçlarına göre tesis genelinde ortalama %88 KOİ, %83 AKM, %26 TP, %83 TN ve %86 Renk giderim verimi elde edilmiştir. Sonuç olarak Denizli Organize Sanayi Bölgesi Merkezi Atıksu Arıtma Tesisinde kimyasal arıtım uygulanmadan sadece fiziksel ve biyolojik arıtma prosesleriyle bile mevzuatta belirtilen sınır değerlere rahatlıkla ulaşılabilmektedir. Tesiste yer alan proseslerin arıtma verimleri alternatif olabilecek proses verimleriyle kıyaslandığında oldukça yüksek verimlerine sahip olduğu görülmektedir.
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    From bio-waste to biomaterials: The eggshells of Chinese oak silkworm as templates for SERS-active surfaces
    (Elsevier B.V., 2021) Zang, Lian-Sheng; Chen, Yong-Ming; Koç Bilican, Behlül; Bilican, İsmail; Şakir, Menekşe; Wait, James; Çolak, Arzu; Karaduman, Tuğçe; Ceylan, Ahmet; Ali, Asad; Elbuken, Çağlar; Önses, M. Serdar; Kaya, Murat
    Although over 80% of the world's existing animal species are insects, with each of these species having unique eggshell morphologies, limited information is available regarding the use of their eggshells in material science applications. The present research discusses using discarded eggshells of the Chinese oak silkworm (Antheraea pernyi) as a technological material. The 3-dimensional aspects of the insect's eggshell were examined in detail, demonstrating the complexity of their novel surface morphology. The outer surface of the eggshell was comprised of a hexagonal structure, whereas the inner surface consists of a mostly smooth surface. Distinctive layers of the eggshell were observed when cross sections of the surface were analyzed. The elastic modulus of the inner part of the eggshell is substantially greater than that of the outer part. The physicochemical properties of the eggshell were characterized and no toxic properties were found. The hexagonal structures found on the outer surface of the eggshell provide a highly suitable template for silver nanostructure deposition. The resulting silver decorated surfaces can be used to detect molecules via surface-enhanced Raman scattering (SERS) effects. The deposition of silver renders the surface antimicrobial, whereas the original surface was microbial. Collectively, the insights gained in this study will be key in developing advanced engineering applications of the insect eggshells.
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    Transplantation of limbal derived MSCs grown on contact lenses in dogs with dry eye syndrome - can stem cells help
    (University of Zagreb, Facultty of Veterinary Medicine, 2021) Boztok Özgermen, Başak; Can, Pınar; Sancak, İrem; Akpınar, Eylül; Pınarlı, Ferda; Ceylan, Ahmet; Özen, Doğukan; Özen, Asuman
    Keratoconjunctivitis Sicca (KCS), also known as “dry eye syndrome”, is a common ocular disease in dogs, caused by inflammation of the lacrimal gland, resulting in decreased tear production. Efforts are being made to develop alternative therapies in order to prevent lifelong use of drugs for patients with KCS. Mesenchymal stem cells (MSCs) are known to be effective in the treatment of many immune-mediated diseases in human and animal models due to their immunoregulatory properties. The aim of this study was to transplant limbal mesenchymal stem cells (LMSCs) to the ocular surface on contact lenses and to evaluate the therapeutic effects of the LMSCs by clinical examination findings. The animals were randomly divided into study and control groups. The LMSC group (n = 10) received LMSCs (at least 2×106 cells) cultured on contact lenses. The conventional treatment group (n = 10) received artificial tears, topical 0.05% Cs A, and antibiotic eye drops, 3 times a day for 4 weeks. The Schirmer test, tear break-up time, impression cytology, Rose Bengal staining, and tear osmolarity were measured in all patients. The findings of the pre-treatment, two weeks and four weeks after the treatment, were evaluated statistically. In both groups, significant improvement was present compared to the pre-treatment findings. However, there was no significant difference between the groups. KCS treatment using LMSCs produced on contact lenses is promising, with its ease of application, non-immunogenic properties and single dose administration.