Yazar "Ceter, Talip" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim
    Öğe
    A new pollen-derived microcarrier for pantoprazole delivery
    (Elsevier Science Bv, 2017) Akyüz, Lalehan; Sargın, İdris; Kaya, Murat; Ceter, Talip; Akata, Ilgaz
    Plant-derived carriers have emerged as promising materials for drug encapsulation. Especially, sporopollenin microcapsules extracted from diverse pollen species have been proved to be effective drug carriers due to their biocompatibility, homogeneity in size, resistance to harsh chemical conditions and high thermal stability. Here in this study, sporopollenin microcapsules were isolated successfully from the pollens of a common tree (Cotylus avellana, the European hazelnut) and used as a carrier for pantoprazole (PaNa) (a proton pump inhibitor). The drug entrapment efficiency was recorded as 29.81%. SEM micrographs clearly showed the drug was loaded into the microcapsules through the apertures of microcapsule and also some drugs were adsorbed on the surface of microcapsules. FT-IR spectra analysis confirmed the drug loading. Thermogravimetric analysis revealed that thermal stability of PaNa was enhanced by encapsulation. In vitro release studies showed that PaNa-loaded sporopollenin microcapsules exhibited better release performance than the control. C. avellana sporopollenin micro capsules can make an efficient carrier for delivery of PaNa. (C) 2016 Elsevier B.V. All rights reserved.
  • Küçük Resim
    Öğe
    Newly isolated sporopollenin microcages from Platanus orientalis pollens as a vehicle for controlled drug delivery
    (Elsevier Science Bv, 2017) Mujtaba, Muhammad; Sargın, İdris; Akyüz, Lalehan; Ceter, Talip; Kaya, Murat
    Sporopollenin microcages were produced from the pollens of Platanus orientalis. Paracetamol was loaded into the microcages. Pollen, sporopollenin, paracetamol and paracetamol-loaded sporopollenin microcages were characterized with FT-IR, TGA and SEM. The analytical analyses demonstrated that sporopollenin microcages were structurally intact, highly reticulated and thermally stable. The loading efficiency of the sporopollenin microcages was found to be 8.2% using the passive loading technique and 23.7% via evaporating loading technique. In vitro release and kinetics studies were performed to test the suitability of sporopollenin microcages for loading. These studies revealed that sporopollenin from P. orientalis can be suggested as a suitable carrier for drug loading and controlled release studies. (C) 2017 Published by Elsevier B.V.