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    Investigation of COL12A1 Gene Polymorphism Profile in Genetic Injury Susceptibility in Football Players Having Anterior Cruciate Ligament Surgery
    (Aksaray Üniversitesi, 2023) Şahin, Kübra; Bozkurt, Nihan; Şavkın, Sadegül; Bülbül, Alpay; İpekoğlu, Gökhan; Çakır, Halil İbrahim
    Aim: Risk factors such as repetitive traumas, overloads, turning, sliding movements, muscle weakness, excessive training intensity and duration, and faulty training in football invite anterior cruciate ligament injuries in athletes. In this context, it is thought that determining the gene profiles of football players to increase their performance and avoid injuries will make a serious contribution to the field in terms of both performance and athlete health. Although the etiology of the molecular mechanisms is not fully understood, many risk factors are associated with anterior cruciate ligament tears, including genetic factors, genes involved in the repair process such as MMPs, or components of the apoptosis pathway. In this study, the relationship between COL12A1 gene polymorphism and anterior cruciate ligament injury in football players who underwent cruciate ligament surgery was investigated. Materials and Methods: 41 patients who had Anterior cruciate ligament (ACL) surgery and 65 age-sex-matched healthy individuals were investigated for COL12A1 A/G polymorphism. Genotyping of COL12A1 A/G was determined using PCR-RFLP. Statistical analysis of the data was done with Epi Information Software and Arlequin Software. A value of p < 0.05 was considered statistically significant. Results: Our study findings showed that there was no significant difference between the patient and control groups in terms of allele frequency and genotype distribution of the COL12A1 polymorphism (p=0.880). Conclusion: The findings of this study suggested that COL12A1 (rs970547) was not associated with susceptibility to anterior cruciate ligament injuries in the Turkish population.