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    Phytochemical Characterization and Assessment of Antioxidant and Anti-Alzheimer Effects of Algerian Seseli Tortuosum
    (Wiley, 2025) Slimani, Abdelkader; Akkal, Wail; Benmekhbi, Ahmed Acheraf; Mosbah, Asma; Çakmak, Yavuz Selim; Lefahal, Mostefa; Bousetla, Ahlem; Bensouici, Chawki; Laouer, Hocine; Akkal, Salah; Nieto, Gema
    HPLC analysis, phytochemical screening, thin layer chromatography, polyphenols and flavonoid contents were conducted to determine the bioactive contents of the Algerian Seseli tortuosum plant. Antioxidant activity was tested using DPPH and ABTS scavenging assays, reducing power, phenanthroline and silver nanoparticle (SNP) assays. The anti-Alzheimer's activity of extracts was also performed invitro and in silico. Phytochemical analysis highlighted the richness ofthe extracts in terms of coumarins, terpenoids and quercetin. The quantitative determination of total polyphenols and flavonoids showed that the highest amounts occurredinthe dichloromethane (DCME) and methanolic (MeOH) extracts. The antioxidant activities indicated a moderate potential. Compared with galantamine, DCME had a significantly greater anti-Alzheimer effect on BChE(CI50=9.14 +/- 1.74 mu g/ml and 34.75 +/- 1.99 mu g/ml respectively). An in silicostudy of anti-Alzheimer activity revealed a significant effect of quercetin(-30,13KJ/mol). Conclusion: This study demonstrated the richness of the phytochemical components of seseli tortuosum,which are responsible for several biological properties, mainly their anti-Alzheimer potential.