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    Pandemic of the century: COVID-19 in inflammatory rheumatic diseases of a national cohort with 3,532 patients
    (Turkish League Against Rheumatism (TLAR), 2024) Yurdakul, Fatma; Bodur, Hatice; Cengiz, Ahmet Kıvanç; Durmaz, Yunus; Duruöz, Mehmet Tuncay; Kaya, Taciser; Ketenci, Sertaç; Cüzdan, Nihan; Güler, Tuba; Günendi, Zafer; Sarıkaya, Selda; Çapkın, Erhan; Önder, Mustafa Erkut; Melikoğlu, Meltem Alkan; Güzel, Rengin; Şen, Nesrin; Ayna, Ata Bora; Akgül, Özgür; Eser, Erhan; Ataman, Şebnem
    This study aimed to assess the clinical outcomes and risk factors for severe coronavirus disease 2019 (COVID-19) in patients with inflammatory rheumatic disease (IRD) of a national cohort. Patients and methods: The multicenter cross-sectional study was carried out between July 15, 2020, and February 28, 2021. Data collection was provided from a national network database system, and 3,532 IRD patients (2,359 males, 1,173 females; mean age: 48.7±13.9 years; range; 18 to 90 years) were analyzed. Demographics, clinics about rheumatic disease, comorbidities, smoking status, being infected with COVID-19, and the course of the infection were questioned by rheumatology specialists. Results: One hundred seventeen patients were infected with COVID-19, the hospitalization rate due to COVID-19 was 58.9%, and the mortality rate was 1.7%. There was no difference between the COVID-19 positive and negative groups in terms of rheumatic disease activities and receiving drugs. It was observed that patients with COVID-19 had worse compliance with isolation rules, and bacillus Calmette-Guérin (BCG) vaccination was less common. The mean age and the rate of smoking of hospitalized COVID-19 patients were higher than those without hospitalization. Conclusion: In this cohort, in which real-life data were analyzed, COVID-19 rates in IRD patients were similar to the general population for the same period. Compliance with the isolation rules and BCG vaccination attracted attention as components that reduce the risk of COVID-19 infection. The risk factors for hospitalization were older age and smoking.
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    Predictive factors for muscle weakness in Rheumatoid arthritis
    (Türkiye Fiziksel ve Rehabilitasyon Uzman Hekimleri Derneği, 2022) Önder, Mustafa Erkut; Kılıçarslan, Ayşegül; Keskin, Esra Dilek; Bodur, Hatice
    We aimed to determine muscle strength in patients with rheumatoid arthritis (RA) and several factors including structural joint damage that may affect decrease in muscle strength. The relations between muscle strength and quality of life and functional disability were examined. Material and Methods: Seventy five RA patients and 51 controls were involved. Demographic characteristics, body mass index, waist circumference, 25-hydroxy vitamin D, and patient global assessments of disease activity (PGA) were documented. Disease Activity Score-28 (DAS28), Visual Analog Scale-Pain (VAS-pain), Health Assessment Questionnaire (HAQ) and the Rheumatoid Arthritis Quality of Life Questionnaire (RAQoL) were calculated. Radiographs of the hands were evaluated by van der Heijde modified Sharp score (vdHSS). Grip strength of both hands was measured by Jamar dynamometer. Results: Demographics (age, gender) were not different between RA patients and control group. Grip strength of patients with RA (22.79±18.58) was lower than control group (26.00±11.25, p=0.04). There was a significant correlation with grip strength and disease duration, tender joint count, VAS-pain, PGA, DAS28, HAQ, RAQoL, erosion and narrowing score (p<0.05). DAS28 and erosion score were associated with grip strength in multivariate analyses p<0.05). Conclusion: This study showed that RA obtains decreased muscle strength, impaired function and quality of life. Joint space narrowing and disease activity are the main parameters that affect muscle strength.
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    Ultrasound-guided genicular nerve block versus physical therapy for chronic knee osteoarthritis: a prospective randomised study
    (Springer Science and Business Media Deutschland GmbH, 2022) Güler, Tuba; Yurdakul, Fatma Gül; Erkut Önder, Mustafa; Erdoğan, Faruk; Yavuz, Kaan; Becenen, Elif; Uçkun, Aslı; Bodur, Hatice
    To compare the effectiveness of ultrasound-guided genicular nerve block (GNB) and physical therapy (PT) in patients with chronic knee osteoarthritis. A prospective randomised study with 102 patients (45–70 years) was performed wherein the patients received ultrasound-guided GNB (n = 51) and PT (n = 51) along with a standard home exercise programme. Scores for pain on a Visual Analogue Scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and 6-min walking test (6MWT) were assessed pre-treatment and at 2- and 12-weeks post-treatment. Both groups were comparable for sociodemographic characteristics. VAS scores (in mm) in the ultrasound-guided GNB group at 0, 2 and 12 weeks were 7.01 ± 1.36; 3.71 ± 2.18; 5.08 ± 2.22 (p < 0.001) and 6.64 ± 1.99; 4.35 ± 1.09; 5.25 ± 1.33, (p < 0.001) in the PT group. While the increase in the 6MWT test in the 2nd week was similar for both groups (p = 0.073), the increase in walking distance was greater in the ultrasound-guided GNB group at 12 weeks (p = 0.046). As compared to PT, ultrasound-guided GNB is beneficial in reducing pain and increasing functional and physical capacity, with greater retention of effects on the physical capacity seen at 12 weeks. Trial registration number: ClinicalTrials.gov (NCT04782401).