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    Evaluation of factors affecting 90-day mortality in patients hospitalized due to pulmonary thromboembolism
    (MediHealth Academy Yayıncılık, 2021) Ateş, Can; Hoşgün, Derya; Aydemir, Semih
    Pulmonary thromboembolism (PTE) is a leading cause of death from vascular events. In the pathophysiology of PTE, inflammatory mediators have been shown to be upregulated and to interact with coagulation factors. In this study, we aimed to investigate the role of symptoms, clinical and radiological findings, and the blood parameters measured at presentation within the first 24 h after the onset of the symptoms in predicting 90-day mortality and intensive care unit (ICU) requirement in patients with PTE. Material and Method: The retrospective study included 264 PTE patients that were followed up at our Chest Diseases clinic and ICU between 2014 and 2019. Results: The 264 patients comprised 55.3% women and 44.7% men with a mean age of 62.80±15.95 years. Of these, 189 of them were hospitalized in the Chest Diseases clinic and the remaining 75 patients were followed up at ICU. Total mortality occurred in 8 (3%) out of 264 patients. Hospital and ICU mortality were determined at 1.9% , 1.1% respectively. The patients comprised 206 (78.0%) nonmassive PTE, 17 (6.5%) submassive PTE, and 41 (15.5%) massive PTE. Risk factors for 90-mortality included white blood cell count (WBC), red blood cell distribution width (RDW), mean platelet volume (MPV)/RDW ratio, right ventricular dilatation (RVD), recombinant tissue plasminogen activator (rtPA) therapy, ICU hospitalization, and increased APACHE II (Acute Physiology and Chronic Health Evaluation II) scores (p<0.05). Conclusion: The results indicated that TTE findings, baseline hemodynamic parameters and symptoms, rtPA therapy, and CBC parameters including WBC, NE, and RDW are significant risk factors for predicting both mortality and ICU requirement.
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    Serum albumin and C-reactive protein/albumin ratio in communityacquired pneumonia
    (MediHealth Academy Yayıncılık, 2022) Hoşgün, Derya; Sayın Gülensoy, Esen; Akpınar, Evrim Eylem; Ogan, Nalan; Ateş, Can; Aydemir, Semih
    Community-acquired pneumonia (CAP) is a common type of respiratory tract infections with high morbidity and mortality. Prognostic role of CRP/Albumin ratio in CAP patients still is unknown. The aim of this study was to investigate the role the CRP/albumin ratio in predicting 30-day mortality and ICU requirement in hospitalized patients with CAP. Material and Method: The study included patients with CAP.Clinical records and plain radiographic images of the patients were retrieved from hospital database and were reviewed for each patient. Results: The 179 CAP patients who were hospitalized were included. CRP level and the CRP/albumin ratio were found to have no significant effect on mortality and ICU requirement (p=0.728, p=0.232, and p=0.110, respectively), whereas low albumin level was associated with high mortality and ICU requirement (p<0.001 for both). Conclusion: Increased albumin concentration was associated with a lower risk of 30-day mortality. The CRP/albumin ratio was found to have no significant role in predicting short-term mortality and morbidity in CAP patients. Further large-scale, multicenter studies are needed to investigate the prognostic value of the CRP/albumin ratio in predicting long-term prognosis in CAP patients.